Pathobiologie/Pathobiochemie Teil 2 Lektion 8 8.11.10 ... - Alex Eberle

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Mutationen im MC1/MC4-Rezeptor- bzw. POMC-Gen
• Mutations in POMC cause
adrenal insufficiency, red
hair, obesity
(Krude et al., 1998)
• Haploinsufficiency at the
MC4-R linked to obesity
(2-5% of cases)
(Yeo et al., 1998; Vaisse et al., 1998)
• Common obesity linked
to chromosome 2
(Comuzzie et al., 1997)
08/11/10 Pathobiologie - HS 2010 - Lektion 8 53