The Principles of Clinical Cytogenetics - Extra Materials - Springer

278
Table 8
Outcome in Early (11–14 Wk) Amniocentesis Studies
No. of Fetal loss Fetal loss rate
patients with rate within (%) a weeks’ Total
outcome data 2 weeks of gestation at time fetal loss Needle
Group Study period in EA group procedure (%) of amniocentesis rate % gauge Comments
Hanson 1979–1986 298 1.7 5/80(6.3), 4.7 20 Loss rate was 3.3% if patients
(1987) (59) 11–13 weeks; with preamniocentesis history
5/228 (2.2) of bleeding were eliminated.
14 weeks
Johnson and Review of six studies, 1240 NAb NA 1–4.7 22 in 5 centers;
Godmilow including Hanson 20 in 1
(1988) (60) (59); 1979–1987 center (59)
Stripparo 1987–1988 397 1.98c 9/208 (4.3), 3.9 22
(1990) (62) 11–13 weeks;
0/176 (0),
14 weeksd Penso 1986–1989 389 0.8e 6/365 (1.6), 3.96 22 Three of 8 newborns with
(1990) (64) 11–13 weeks; postural deformities born after
3/42 (7.1), postamniocentesis fluid leak.
14 weeks
Hanson 1986–1987 517 0.8 6/272 (2.2),
(1990) (65) 11–13 weeks;
5/255 (1.96),
14 weeks 2.5 20
Crandall 1988–1993 681 0.9 13/681 (1.9), 1.9% for EA; 22; some- EA was compared to conventional
(1994) (67) 11–14 weeks 0.97% for times 25 amnio; spontaneous abortion rate
13/1,342 (0.97), conventional was significantly higher in EA group.
15–22 weeks amniocentesis group. 0.6% EA group had hip
dislocation or clubfeet compared to
0.22% in conventional amnio group.
a This figure includes spontaneous abortions, stillbirths, and neonatal deaths.
b NA = Not available.
c One hundred eight 15-weeks’ gestation amnios were included in this figure.
d Data based on status at 28 weeks gestation.
e Fetal loss within 4 weeks.
278 Linda Marie Randolph