Inhibitor SourceBook™ Second Edition

Phosphorylation/Dephosphorylation
Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors, continued
Product Cat. No. Comments Size Price
Lavendustin C 234450 [Compound 5; 5-(N-2´,5´-Dihydroxybenzyl)aminosalicylic Acid]
Potent inhibitor of CaM kinase II (IC 50 = 200 nM) and pp60 c-src (IC 50 = 200 nM).
N PP Analog II,
NM-PP
529581 A cell-permeable PP analog (Cat. No. 529579) that acts as a potent and selective ATPcompetitive
inhibitor of a variety of mutant kinases over wild-type (IC 50 = 3.2 nM for
T339G, c-Fyn-as vs. .0 mM for c-Fyn; 4.3 nM for I338G, v-src-as vs. 28 mM for v-src;
5 nM for F80G, CDK2-as vs. 29 mM for CDK2; 8 nM for F89G, CAMK IIa-as vs.
24 mM for CAMKII; 20 nM for T3 5A, c-Abl-as2 vs. 3.4 mM for c-Abl). Shown to
activate mutants of Ire , a transmembrane kinase.
STO-609 570250 A cell-permeable, highly selective, potent, ATP-competitive inhibitor of CaM kinase kinase
(CaM-KK) (IC 50 = 320 nM and 06 nM for CaM-KKa and CaM-KKb isoforms, respectively).
Binds to the catalytic domain of CaM-KK, and inhibits autophosphorylation.
TX-1918
A cell-permeable, potent inhibitor for eEF2 kinase (IC 50 = 440 nM).
Inhibits other kinases at much higher concentrations (IC 50 = 4.4, 44, 44,
and 440 mM for Src, PKA, PKC, and EGFR kinase, respectively).
Cat. No. 655203 10 mg $90
Including Oncogene
Research Products
mg $62
mg $82
5 mg $ 73
Featuring 50
NEW products
8 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem