Inhibitor SourceBook™ Second Edition

Other Inhibitors of Biological Interest
Phosphodiesterase Inhibitors, continued
Product Cat. No. Comments Size Price
3-Isobutyl- -methylxanthine 410957 (IBMX)
8-Methoxymethyl-3-isobutyl- -
methylxanthine
4-{[3´,4´-(Methylenedioxy)benzyl]
amino}-6-methoxyquinazoline
A cell-permeable, non-specific inhibitor of cAMP and cGMP
phosphodiesterases (IC 50 = 2–50 mM).
454202 (8-Methoxymethyl-IBMX)
A cell-permeable, selective inhibitor of PDE I (IC 50 = 4 mM).
58 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem
250 mg
g
$45
$ 7
0 mg $ 0
475250 A potent and specific inhibitor of PDE V (IC 50 = 230 nM). mg $69
Milrinone 475840 [1,6-Dihydro-2-methyl-6-oxo-(3,4´-bipyridine)-5-carbonitrile]
A cell-permeable, selective inhibitor of PDE III (IC 50 = 300 nM).
MY-5445 474925 [1-(3-Chlorophenylamino)-4-phenylphthalazine]
A cell-permeable, selective inhibitor of PDE V (IC 50 = 600 nM).
N Phosphodiesterase 4 Inhibitor 524717 [3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl
ester]
A high-affinity active site binding inhibitor of phosphodiesterases
IVB and IVD (IC 50 = 33 and 2 nM, respectively).
Phosphodiesterase V Inhibitor II 524714 (PDE V Inhibitor II)
A cell-permeable, potent, and highly selective phosphodiesterase V
inhibitor (IC 50 = 5 nM for bovine aorta PDE V; IC 50 > 0 mM for human
recombinant PDE I & III, and for bovine aorta PDE II & IV).
Ro-20- 724 557502 [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone]
A cell-permeable, selective inhibitor of PDE IV (IC 50 = 2 mM).
Rolipram 557330 {4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone}
A cell-permeable, selective and competitive inhibitor of PDE IV
(IC 50 = 800 nM). Does not inhibit PDE I or PDE II, even at
00 mM. Only a weak inhibitor of PDE III (IC 50 = 00 mM). A rolipraminsensitive
PDE IV subtype is also known to exist.
Trequinsin, Hydrochloride 382425 [9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4Hpyrimido-(6,1-a)-isoquinolin-4-one,
HCl; HL 725]
A cell-permeable and extremely potent inhibitor of PDE III
(IC 50 = 300 pM) and platelet aggregation in vitro.
0 mg $ 75
0 mg $ 7
0 mg $ 29
5 mg $84
00 mg $6
5 mg $ 28
0 mg $ 82
Vinpocetine 677500 A selective inhibitor of PDE I (IC 50 = 20 mM). 20 mg $67
W-5, Hydrochloride 681625 [N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl]
A cell-permeable, calmodulin antagonist that inhibits PDE I
(IC 50 = 240 mM).
W-7, Hydrochloride 681629 [N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl]
A calmodulin antagonist that inhibits PDE I (IC 50 = 28 mM). A cerebral
vasodilator.
W- 2, Hydrochloride 681635 [N-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl]
A calmodulin antagonist that inhibits PDE I (IC 50 = 260 mM).
W- 3, Hydrochloride 681636 [N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl]
A calmodulin antagonist that inhibits PDE I (IC 50 = 68 mM).
Zaprinast 684500 {1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo
[4,5-d]pyrimidine-7-one; M&B22948}
Phosphodiesterase Inhibitor Set I
A cell-permeable, selective inhibitor of PDE V (IC 50 = 450 nM). Inhibits
PDE IX at much higher concentrations (IC 50 = 35 mM).
mg $77
0 mg $77
mg $77
mg $77
25 mg $49
Provided as a set of 4 vials. Each set contains 0 mg of 8-Methoxymethyl-3-isobutyl- -methylxanthine (Cat. No. 454202), a Ca 2+ /CaM-dependent
PDE (PDE I) inhibitor; mg of 4-{[3,4 -(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), a cGMP-specific PDE (PDE V)
inhibitor; 5 mg of Rolipram (Cat. No. 557330), a cAMP-specific PDE (PDE IV) inhibitor; and 0 mg of Trequinsin, Hydrochloride (Cat. No. 382425), a
cGMP-inhibited PDE (PDE III) inhibitor.
Cat. No. 524718 1 set $347