Inhibitor SourceBook™ Second Edition

Phosphorylation/Dephosphorylation
Protein Phosphatase Inhibitors, continued
Product Cat. No. Comments Size Price
,4-Dimethylendothall 311250 (1,4-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid)
A useful negative control for Canthardic Acid (Cat. No. 2 0 50), Canthardin
(Cat. No. 2 0 55), and Endothall (Cat. No. 324760).
N eIF-2a Inhibitor,
Salubrinal
324895 (Sal)
A cell-permeable thiourea compound that acts as a selective inhibitor of eukaryotic
translation initiation factor 2 subunit a (eIF-2a) dephosphorylation by phosphatase
complexes.
Endothall 324760 (7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid)
A specific inhibitor of PP2A (IC 50 = 90 nM).
Fenvalerate 341380 [a-Cyano-3-phenoxybenzyl-a-(4-chlorophenyl)isovalerate]
A potent inhibitor of PP2B (IC 50 = 2–4 nM).
Fostriecin, Sodium
Salt, Streptomyces
pulveraceous
b-Glycerophosphate,
Disodium Salt,
Pentahydrate
Microcystin-LF,
Microcystis aeruginosa
Microcystin-LR,
Microcystis aeruginosa
InSolution
Microcystin-LR,
Microcystis aeruginosa
Microcystin-LW,
Microcystis aeruginosa
Microcystin-RR,
Microcystis aeruginosa
344280 (FST; Phosphotrienin)
A potent PP2A inhibitor (IC 50 = 3.2 nM). Inhibits PP only at higher concentrations
(IC 50 = 3 mM).
35675 A phosphate group donor in matrix mineralization studies that acts as a protein
phosphatase inhibitor.
475814 A more cell-permeable analog of Microcystin-LR (Cat. No. 4758 5). Useful for studies
in intact cells. Not available for sale outside the United States.
475815 A cyclic peptide that inhibits PP2A~PP >> PP2B (IC 50 for PP2A = 40 pM and for
PP = .7 nM). Does not enter some mammalian cells. Not available for sale outside
the United States.
475821 A 2.5 mM (250 mg/ 00 ml) of Microcystin-LR, Microcystis aeurginosa
(Cat. No. 4758 5) in DMSO. Not available for sale outside the United States.
475818 A more cell-permeable analog of Microcystin-LR (Cat. No. 4758 5). Useful for studies
in intact cells. Not available for sale outside the United States.
475816 A cyclic peptide that inhibits PP2A~PP >> PP2B (IC 50 = .4 mM). Does not enter some
mammalian cells. Not available for sale outside the United States.
mpV(pic) 475950 [Monoperoxo(picolinato)oxovanadate(V)]
A potent PTP inhibitor. More potent for insulin receptor (IR) dephosphorylation than
EGFR dephosphorylation.
a-Naphthyl
Acid Phosphate,
Monosodium Salt
NFAT Activation
Inhibitor III
NIPP- , His•Tag®,
Bovine Thymus,
Recombinant, E. coli
Okadaic Acid,
Prorocentrum
concavum
N InSolution Okadaic
Acid, Prorocentrum
concavum
Okadaic Acid,
Ammonium Salt
0 mg $76
5 mg $ 29
20 mg $55
25 mg $55
0 mg $ 7
60 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem
50 g
00 g
250 g
$32
$48
$98
25 mg $ 4
500 mg $ 78
250 mg $ 0
25 mg $ 5
250 mg $202
0 mg $ 7
479775 A broad-spectrum protein phosphatase inhibitor. 5 g $44
480403 INCA-6; Inhibitor of NFAT-Calcineurin Association-6
A cell-permeable quinone compound that acts as a potent and selective inhibitor of
Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with
high affinity (K d = 800 nM), disrupts its interaction with NFAT and completely blocks its
dephosphorylation, nuclear import of NFAT (~40 mM in C .7W2 T cells), and induction of
cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin
activity or its downstream signaling.
482251 (Nuclear Inhibitor of Protein Phosphatase-1)
A potent and specific inhibitor or protein phosphatase (PP ; K i = – 0 pM) that can be used
to distinguish PP from other major serine/threonine protein phosphatases, including PP2A,
PP2B, and PP2C.
495604 (OA)
A cell-permeable inhibitor of PP2A > PP >> PP2B. (IC 50 for PP2A = 00 pM;
for PP = 0– 5 nM; and for PP2B = 5 mM).
495609 A 250 mM (25 mg/ 24 ml) solution of Okadaic Acid, Prorocentrum concavum
(Cat. No. 495604) in DMSO.
459616 A water-soluble form of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases
and 2A.
5 mg $90
0 mg
25 mg
00 mg
mg $95
$40
$65
$2 2
25 mg $65
25 mg $60