Inhibitor SourceBook™ Second Edition

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Nitric Oxide/Oxidative Stress Nitric Oxide Synthase, Inducible, Inhibitor Set (iNOS Inhibitor Set) Provided as a 5 vial set. Each set contains 5 mg of 400W (Cat. No. 00050); 0 mg of -Amino-2-hydroxyguanidine, p-Toluenesulfonate (Cat. No. 55200); 00 mg of S-Methylisothiourea Sulfate (Cat. No. 466220); 0 mg of L-NIL, Dihydrochloride (Cat. No. 482 00); and 50 mg of ,3-PBITU, Dihydrobromide (Cat. No. 5 2774). Cat. No. 482760 1 set $340 Related Products Nitric Oxide Assay Kit, Colorimetric Assay kit for the rapid quantitative measurement of total nitric oxide (NO). Based on the enzymatic conversion of nitrate to nitrite by nitrate reductase, followed by the spectrophotometric quantitation of nitrite levels using Griess Reagent. Do not use with nitrate- or nitritecontaining tissue culture media such as RPMI. kit = 50 tests. Cat. No. 482650 1 kit $286 Nitric Oxide Assay Kit, Fluorometric Assay kit useful for the rapid quantitative measurement of nitric oxide (NO). Displays 50-fold increased sensitivity over the colorimetric nitric oxide assay kit (Cat. No. 482650). The assay is based on the enzymatic conversion of nitrate to nitrite by nitrate reductase, followed by the addition of 2,3-diaminonapthalene (DAN), and NaOH, which converts nitrite to a fluorescent compound. Fluorescence measurements of - this compound accurately determine the nitrite (NO ) concentration 2 (excitation max.: 365 nm; emission max.: 450 nm). Do not use with nitrate- or nitrite-containing tissue culture media such as RPMI. kit = 80 tests. Cat. No. 482655 1 kit $286 NOS Inhibitor Set Contains 20 mg of L-N 5 -( -Iminoethyl)ornithine, HCl (Cat. No. 400600), 0 mg of S-Methyl-L-thiocitrulline, HCl (Cat. No. 472804), 25 mg of N G -Monomethyl-L-arginine, Monoacetate Salt (Cat. No. 475886), 00 mg of N G -Nitro-L-arginine Methyl Ester, HCl (Cat. No. 483 25), 00 mg of N G -Nitro-D-arginine Methyl Ester, HCl, 00 mg of 7-Nitroindazole (Cat. No. 483400), and 0 mg of L-Thiocitrulline, HCl (Cat. No. 5894 ). Cat. No. 490075 1 set $380 Nitric Oxide Synthase Assay Kit Assay kit useful for the rapid quantitative measurement of nitric oxide synthase (NOS) activity. It is based on the conversion of radioactive L-arginine to L-citrulline by NOS. Radioactive citrulline is separated from unreacted arginine on a cation-exchange resin and quantitated. kit = 50 tests. Cat. No. 482700 1 kit $329 Nitric Oxide Synthase Assay Kit, Colorimetric Assay kit useful for the rapid and accurate measurement of nitric oxide synthase (NOS) activity. This colorimetric assay uses lactate dehydrogenase (LDH) to destroy excess NADPH (cofactor for NOS) which interferes with the chemistry of Griess Reagent, commonly used for nitrite/nitrate detection. Do not use with nitrate- or nitritecontaining tissue culture media such as RPMI. kit = 96 tests. Cat. No. 482702 1 kit $286 2 Orders Phone 800 854 34 7 Calbiochem • Inhibitor SourceBook Fax 800 776 0999 Web www.emdbiosciences.com/calbiochem
Proteases Anthrax Lethal Factor (LF) Metalloprotease Inhibitors Calbiochem • Inhibitor SourceBook Proteases Product Cat. No. Comments Size Price Anthrax Lethal Factor Protease 176901 [Anthrax LF Protease Inhibitor; Bacillus anthracis LF Protease Inhibitor; mg $ 95 Inhibitor, In-2-LF In-2-LF] N Anthrax Lethal Factor Protease Inhibitor III More online... www.calbiochem.com/inhibitors/ALF A cell-permeable N-acetylated, C-hydroxamate derivative of a 4-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of anthrax lethal factor (LF) metalloprotease (K = nM). i Also inhibits MEK-3 cleavage. Protects against anthrax toxin induced cytotoxicity in RAW264.7 and J772.A cells. 176910 [BI-11B3; 5-(5-(2-Chloro-5-trifluoromethyl-phenyl)-furan-2ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl)-acetic acid] A cell-permeable, rhodanine-acetic acid analog that chelates the active site Zn2+ and acts as a potent inhibitor of anthrax lethal factor (LF) metalloproteinase (K = 32 nM). Exhibits only minimal inhibition of i MMP-2 and MMP-9. Shown to effectively prevent LF-induced MAPKK proteolysis (< 2 mM) and offer protection against LF and protective antigen (PA) cytotoxic effects in RAW264.7 cells (IC < 5 mM). In 50 combination with the antibiotic ciprofloxacin, doubly enhances the survival rates of mice challenged with anthrax spores. 5 mg $ 29 Technical Support Phone 800 628 8470 E-mail calbiochem@emdbiosciences.com 3
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Inhibitor SourceBook Second Editio
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Calbiochem • Inhibitor SourceBook
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Akt (Protein Kinase B) Inhibitors,
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Calmodulin-Dependent Protein Kinase
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Casein Kinase (CK) Inhibitors Casei
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Checkpoint Kinase Inhibitors Eukary
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Cyclin-Dependent Kinase (Cdk) Inhib
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Glycogen Synthase Kinase-3 (GSK-3)
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Glycogen Synthase Kinase Inhibitors
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c-Jun N-Terminal Kinase (JNK/SAP Ki
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Mitogen-Activated Protein (MAP) Kin
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MAP Kinase Inhibitors, continued Ca
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Myosin Light Chain Kinase (MLCK) In
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Phosphatidylinositol 3-Kinase (PI 3
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Protein Kinase A (PKA; cAMP-Depende
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Isozyme Specificities of Selected P
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Protein Kinase C (PKC) Inhibitors,
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Protein Tyrosine Kinase (PTK) Inhib
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Raf Kinase Inhibitors Raf kinases a
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Rho Kinase (ROCK) Inhibitors, conti
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Protein Phosphatase Inhibitors Calb
Page 63 and 64: Protein Phosphatase Inhibitors, con
Page 65 and 66: Apoptosis Caspase Inhibitors Activa
Page 67 and 68: Caspase Inhibitors, continued Produ
Page 69 and 70: Other Selected Inhibitors of Apopto
Page 71 and 72: Calbiochem • Inhibitor SourceBook
Page 73 and 74: DNA Methyltransferase Inhibitors DN
Page 75 and 76: Histone Acetylase and Deacetylase I
Page 77 and 78: Related Products Histone Deacetylas
Page 79 and 80: Nuclear Import/Export Inhibitors, c
Page 83 and 84: Telomerase Inhibitors, continued Ca
Page 85 and 86: Topoisomerase Related Inhibitors, c
Page 87 and 88: Lipid Signaling Acetyl-CoA Carboxyl
Page 89 and 90: Cyclooxygenase (COX) Inhibitors, co
Page 91 and 92: HMG-CoA (3-Hydroxy-3-Methylglutaryl
Page 93 and 94: Lipoxygenase (LOX) Inhibitors Lipox
Page 95 and 96: Phospholipase Inhibitors Several si
Page 97 and 98: Sphingomyelinase Inhibitors Ceramid
Page 99 and 100: Amyloidogenesis Inhibitors Calbioch
Page 101 and 102: Secretase Inhibitors Deposition of
Page 103 and 104: Secretase Inhibitors Calbiochem •
Page 107 and 108: Glutathione S-Transferase (GST) Inh
Page 109 and 110: Guanylate Cyclase Inhibitors, conti
Page 111 and 112: Characteristics of various forms of
Page 113: Nitric Oxide Synthase (NOS) Inhibit
Page 117 and 118: the ratio of active (76 kDa) to ina
Page 119 and 120: Collagenase Inhibitors (Also see Ma
Page 121 and 122: Matrix Metalloproteinase (MMP) Inhi
Page 123 and 124: Matrix Metalloproteinase Inhibitors
Page 125 and 126: Tissue Inhibitors of Matrix Metallo
Page 127 and 128: Protease Inhibitors The proper func
Page 129 and 130: Protease Inhibitors, continued Calb
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Page 133 and 134: Protease Inhibitors, continued Sele
Page 135 and 136: Protease Inhibitor Cocktails, conti
Page 137 and 138: N Animal-Free Protease Inhibitor Co
Page 139 and 140: Proteasome and Ubiquitination Pathw
Page 141 and 142: Transmembrane receptors of various
Page 143 and 144: Angiotensin-Converting Enzyme (ACE)
Page 145 and 146: ATPase Inhibitors, continued Calbio
Page 149 and 150: Inhibitors of Glycoprotein Processi
Page 151 and 152: Heat Shock Protein Inhibitors Heat
Page 153 and 154: Inhibitors of Mitochondrial Functio
Page 155 and 156: NF-kB Activation Inhibitors NF-kB,
Page 157 and 158: NF-kB Activation Inhibitors, contin
Page 159 and 160: Phosphodiesterase (PDE) Inhibitors
Page 161 and 162: Plasminogen Activator Inhibitors Ti
Page 163 and 164: Protein Synthesis Inhibitors, conti
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Sonic Hedgehog Signaling Inhibitors
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Why can’t I make serial dilutions
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Calpastatin, Human, Recombinant, Do
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InSolution Microcystin-LR, Microcys
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RNA Polymerase III Inhibitor ......
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324875 ............................
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Trademarks CALBIOCHEM®
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Your #1 Resource for Inhibitors! We
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