Inhibitor SourceBook™ Second Edition

Proteases
Matrix Metalloproteinase (MMP Groups)
Group MMP
Simple Hemopexin Domain-Containing MMPs MMP- , MMP-3, MMP-8, MMP- 0, MMP- 2, MMP- 3,
MMP- 8, MMP- 9, MMP-20, MMP-22, and MMP-27
Gelatin-Binding MMPs MMP-2 and MMP-9
Furin-Activated Secreted MMPs MMP- and MMP-28
Vitronectin-Like Insert MMPs MMP-2
Minimal Domain MMPs MMP-7 and MMP-26
GPI-linked MMPs MMP- 7 and MMP-25
Type I Transmembrane MMPs MMP- 4, MMP- 5, MMP- 6, and MMP-24
Type II Transmembrane MMPs MMP-23
Matrix Metalloproteinase Inhibitors
Product Cat. No. Comments Size Price
Chlorhexidine, Dihydrochloride 220557 1,6-bis[N´-(p-Chlorophenyl)-N5-biguanido]hexane, 2HCl, CH
An antimicrobial agent that acts as an inhibitor of MMP-2 and MMP-9;
however, MMP-2 is more sensitive to chlorhexidine than MMP-9.
CL-82 98 233105 A selective inhibitor of MMP- 3 (IC = 0 mM) that does not appear
50
to act by chelating Zn2+ . Binds within the entire S ´ pocket of MMP- 3,
docking with the morpholine ring adjacent to the catalytic zinc atom.
Does not inhibit MMP- , MMP-9, or TACE.
GM 489 364200 {N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)methyl-benzylamide}
A potent broad-spectrum inhibitor of MMPs. Inhibits MMPs in vitro
(K = 200 pM for MMP- ; 500 nM for MMP-2; 20 mM for MMP-3;
i
00 nM for MMP-8; 00 nM for MMP-9).
GM 600 364205 {Galardin; N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-
L-tryptophan Methylamide}
A potent broad-spectrum hydroxamic acid inhibitor of MMPs. Inhibits
MMPs in vitro (K = 400 pM for skin fibroblast MMP- ; 500 pM for
i
MMP-2; 27 nM for MMP-3; 0. nM for MMP-8; and 200 pM for MMP-9).
00 mg $28
5 mg $96
N InSolution GM600 364206 A 0 mM ( mg/257 ml) solution of GM600 (Cat. No. 364205) in DMSO. mg $62
GM 600 , Negative Control 364210 (N-t-Butoxycarbonyl-L-leucyl-L-tryptophan Methylamide)
A useful negative control for the MMP inhibitor GM 600
(Cat. No. 364205).
MMP Inhibitor I 444250 (FN-439)
An inhibitor of MMP- and MMP-8 (IC = .0 mM), MMP-9
50
(IC = 30 mM), and MMP-3 (IC = 50 mM).
50 50
MMP Inhibitor II 444247 {N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]piperazine-2-carboxamide}
An inhibitor of MMP- (IC = 24 nM), MMP-3 (IC = 8.4 nM), MMP-7
50 50
(IC = 30 nM), and MMP-9 (IC = 2.7 nM).
50 50
MMP Inhibitor III 444264 A homophenylalanine-hydroxamic acid based broad-spectrum cellpermeable,
reversible inhibitor of matrix metalloproteinases (supplied
as a racemic mixture). Inhibits MMP- (IC = 7.4 nM), MMP-2
50
(IC = 2.3 nM), MMP-3 (IC = 35 nM), MMP-7 (IC = 0– 00 nM),
50 50 50
and MMP- 3 (IC = – 0 nM).
50
MMP Inhibitor IV 444271 (HONH-COCH CH CO-FA-NH )
2 2 2
A peptide hydroxamic acid that inhibits MMPs and pseudolysin from
P. aeruginosa (~500 nM).
MMP-2 Inhibitor I 444244 (OA-Hy; cis-9-Octadecenoyl-N-hydroxylamide; Oleoyl-N-hydroxylamide)
A potent inhibitor of MMP-2 (K i = .7 mM).
MMP-2 Inhibitor II 444286 An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a
selective, active site-binding, irreversible inhibitor of MMP-2
(K i = 2.4 µM).
20 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
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mg
5 mg
mg
5 mg
mg
5 mg
$62
$20
$62
$20
$62
$20
0 mg $ 36
mg $ 5
mg $ 0
5 mg $ 0
0 mg $67
5 mg $ 44