Inhibitor SourceBook™ Second Edition

Other Inhibitors of Biological Interest
NF-kB Activation Inhibitors
Product Cat. No. Comments Size Price
BAY -7082 196870 {(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile}
Potential anti-inflammatory agent that selectively and irreversibly
inhibits the TNFa-inducible phosphorylation of IkBa (IC 50 = 0 mM)
without affecting the constitutive IkBa phosphorylation. Decreases
nuclear translocation of NF-kB and inhibits TNFa-induced surface
expression of the endothelial-leukocyte cell adhesion molecules
E-selectin, VCAM- , and ICAM- .
N InSolution BAY -7082 196871 A 00 mM ( 0 mg/483 ml) solution of BAY -7082
(Cat. No. 96870) in DMSO.
BAY -7085 196872 {(E)3-[(4-t-Butylphenyl)sulfonyl]-2-propenenitrile}
Exhibits biological properties similar to that of BAY -7082
(Cat. No. 96870). BAY -7085 has also been shown to have potent
anti-inflammatory properties in vivo.
CAPE 211200 (Caffeic Acid Phenethyl Ester, Synthetic)
An active component of propolis from honeybee hives with antiviral,
anti-inflammatory, and immunomodulatory properties. Has been
shown to act as a potent and specific inhibitor of NF-kB activation.
(E)-Capsaicin 211274 {[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6nonenamide}
An active constituent of cayenne pepper that has anti-nociceptive
and anti-inflammatory effects. Inhibits NF-kB activation by TNF-a.
N Evodiamine, Evodia rutaecarpa 341211 A cell-permeable quinazolinocarboline that suppresses both
inducible and constitutive NF-kB activation and
NF-kB-regulated gene expression by inhibiting IKK activation.
Gliotoxin, Gladiocladium
fimbriatum
Helenalin, A. chamissonis ssp.
foliosa
371715 {2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-
3a,10a-epidithio-pyrazinol[1,2a]indole-1,4-dione}
An immunosuppressive secondary metabolite produced by several
pathogenic fungi that specifically inhibits NF-kB activation in B and
T cells at nanomolar concentrations.
374000 A cell-permeable pseudoguainolide sesquiterpenoid lactone that
inhibits NF-kB-DNA binding activity by selectively alkylating the p65
subunit of NF-kB. Does not inhibit IkB degradation or NF-kB nuclear
translocation.
Hypoestoxide, Hypoestes rosea 401006 A naturally occurring, cell-permeable diterpene with antiinflammatory
properties. Acts as a selective and direct inhibitor of
IkB kinase (IC 50 = 24 mM) in TNF-a stimulated HeLa cells thereby
prevents NF-kB activation.
IkB Kinase Inhibitor Peptide,
Cell-Permeable
IkB Kinase Inactive Control
Peptide, Cell-Permeable
401477 (Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH 2 )
A 4-amino acid peptide corresponding to the active IkB
phosphorylation recognition sequence, linked to the hydrophobic
region of the fibroblast growth factor signal peptide to aid in cellular
delivery. Specifically inhibits LPS-induced IkB degradation by IkB
kinases (IKK) in RAW 264.7 cells ( 0 mM) or TNF-a production
(IC 50 > 0 mM).
401478 (Ac-AAVALLPAVLLALLAPDDRHDAGLDAMKDE-NH 2 )
An inactive control for IkB Kinase Inhibitor Peptide (Cat. No.
40 477). Corresponds to the mutated recognition sequence of IkB
(Ser 32 → Ala and Ser 36 → Ala), linked to the hydrophobic region of
the fibroblast growth factor signal peptide to aid in cellular delivery.
Does not have any inhibitory effect on LPS-induced IkB degradation
by IkB kinases (IKK) in RAW 264.7 cells at 50 mg/ml.
IKK Inhibitor II, Wedelolactone 401474 (7-Methoxy-5,11,12-trihydroxy-coumestan; Wedelolactone, Eclipta alba)
The naturally isolated active ingredient of the herbal medicine,
Eclipta alba, that acts as a selective and irreversible inhibitor of IKKa
and b kinase activity (IC 50 < 0 mM). Inhibits NF-kB-mediated gene
transcription in cells by blocking the phosphorylation and degradation
of IkB.
0 mg $68
0 mg $68
0 mg $88
25 mg $ 00
00 mg $62
5 mg $ 49
mg $8
500 mg $ 35
mg $ 50
mg $ 90
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mg
mg
$ 95
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