Inhibitor SourceBook™ Second Edition

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Apoptosis Caspase Inhibitors Product Cat. No. Sequence Cell - Permeable Reversible? Known Target Caspases (or Granzyme B) Size Price Caspase Inhibitor I 627610 Z-VAD(OMe)-FMK a Yes No General mg $ 84 InSolution Caspase Inhibitor I 627609 Z-VAD(OMe)-FMK a Yes No General mg $ 84 Caspase Inhibitor I, Biotin Conjugate 218742 Biotin-X-VAD(OMe)-FMK a — No General mg $355 Caspase Inhibitor II 218735 Ac-VAD-CHO ‡ No Yes General mg $65 Caspase Inhibitor II, Cell-Permeable 218830 Ac-AAVALLPAVLLALLAPVAD- CHO Yes Yes General mg $ 64 Caspase Inhibitor III 218745 Boc-D(OMe)-FMK a Yes No General 250 mg mg Caspase Inhibitor IV 218784 Boc-D(OBzl)-CMK b Yes No General 5 mg $60 Caspase Inhibitor VI 219007 Z-VAD-FMK a — No General 250 mg mg N InSolution Caspase Inhibitor VI 219011 Z-VAD-FMK a — No General mg $ 82 Caspase Inhibitor VIII 218729 Ac-VDVAD-CHO No Yes 2, 3, 7 mg $99 N Caspase Inhibitor X 218723 — No Yes 3, 7, 8 5 mg $ 8 Caspase Inhibitor, Negative Control 342000 Z-FA-FMK Yes No mg 5 mg Caspase- Inhibitor I 400010 Ac-YVAD-CHO ‡ No Yes , 4 mg 5 mg Caspase- Inhibitor I, Cell-Permeable 400011 Ac-AAVALLPAVLLALLAP- YVAD-CHO 64 Orders Phone 800 854 34 7 Calbiochem • Inhibitor SourceBook Fax 800 776 0999 Web www.emdbiosciences.com/calbiochem $57 $ 44 $62 $ 82 $77 $3 3 $60 $243 Yes Yes , 4 mg $ 70 Caspase- Inhibitor II 400012 Ac-YVAD-CMK b Yes No , 4 5 mg $208 Caspase- Inhibitor II, Biotin Conjugate 400022 Biotin-YVAD-CMK b — No , 4 5 mg $297 Caspase- Inhibitor IV 400015 Ac-YVAD-AOM d Yes No , 4 mg $95 Caspase- Inhibitor V 400019 Z-Asp-CH 2 -DCB e Yes No , 4 5 mg $362 Caspase- Inhibitor VI 218746 Z-YVAD(OMe)-FMK a Yes No , 4 250 mg mg Caspase-2 Inhibitor I 218744 Z-VD(OMe)VAD(OMe)-FMK a Yes No 2 250 mg mg Caspase-2 Inhibitor II 218814 Ac-LDESD-CHO No Yes 2, 3 mg 5 mg Caspase-3 Inhibitor I 235420 Ac-DEVD-CHO ‡ No Yes 3, 6, 7, 8, 0 mg 5 mg Caspase-3 Inhibitor I, Biotin Conjugate Caspase-3 Inhibitor I, Cell-Permeable InSolution Caspase-3 Inhibitor I, Cell-Permeable $88 $263 $ $3 0 $73 $286 $68 $267 235422 Biotin-DEVD-CHO ‡ — Yes 3, 6, 7, 8, 0 mg $ 7 235423 Ac-AAVALLPAVLLALLAP- DEVD-CHO 235427 Ac-AAVALLPAVLLALLAP- DEVD-CHO Caspase-3 Inhibitor II 264155 Z-D(OMe)E(OMe)VD(OMe)- FMK a InSolution Caspase-3 Inhibitor II 264156 Ac-AAVALLPAVLLALLAP- DEVD-CHO Caspase-3 Inhibitor II, Biotin Conjugate 218747 Biotin-X- D(OMe)E(OMe)VD(OMe)- FMK a Yes Yes 3, 6, 7, 8, 0 mg $ 56 Yes Yes 3, 6, 7, 8, 0 mg $ 56 Yes No 3, 6, 7, 8, 0 250 mg mg $8 $227 Yes Yes 3, 6, 7, 8, 0 250 mg $83 — No 3, 6, 7, 0 mg $366 Caspase-3 Inhibitor III 218750 Ac-DEVD-CMK b Yes No 3, 6, 7, 8, 0 mg 5 mg Caspase-3 Inhibitor IV 235421 Ac-DMQD-CHO ‡ No Yes 3 mg 5 mg Caspase-3 Inhibitor V 219002 Z-D(OMe)QMD(OMe)-FMK Yes No 3 mg $238 Key: a: FMK = Fluoromethyl ketone; b: CMK = Chloromethyl ketone; c: FAOM = 2,6-bis(trifluoromethyl) benzoyloxymethyl ketone; d: AOM = 2,6dimethylbenzoyloxy ketone; e: DCB = 2,6 dichlorobenzoyloxy; ‡: These aldehyde-based inhibitors may be cell-permeable, albeit to a lesser extent. $66 $26 $83 $275
Caspase Inhibitors, continued Product Cat. No. Sequence Calbiochem • Inhibitor SourceBook Cell - Permeable Reversible? Known Target Caspases (or Granzyme B) Apoptosis Size Price N Caspase-3 Inhibitor VII 219012 — Yes Yes 3 mg $ 35 Caspase-3/7 Inhibitor I 218826 — Yes Yes 3, 7 mg $96 N Caspase-3/7 Inhibitor II 218832 Ac-DNLD-CHO ‡ No Yes 3, 7, 8, 9 mg $90 Caspase-4 Inhibitor I 218755 Ac-LEVD-CHO ‡ No Yes 4 mg $62 Caspase-4 Inhibitor I, Cell-Permeable 218766 Ac-AAVALLPAVLLALLAP- LEVD-CHO Yes Yes 4 mg $ 65 Caspase-5 Inhibitor I 218753 Z-WE(OMe)HD(OMe)-FMK a Yes No , 4, 5 250 mg mg Caspase-6 Inhibitor I 218757 Z-VE(OMe)ID(OMe)-FMK a Yes No 6 250 mg mg Caspase-6 Inhibitor II, Cell-Permeable Caspase-8 Inhibitor I, Cell-Permeable 218767 Ac-AAVALLPAVLLALLAP- VEID-CHO 218773 Ac-AAVALLPAVLLALLAP- IETD-CHO $ 3 $3 9 $92 $26 Yes Yes 6 mg $ 70 Yes Yes 8, Granzyme B mg $ 70 Caspase-8 Inhibitor II 218759 Z-IE(OMe)TD(OMe)-FMK a Yes No 8, Granzyme B 250 mg mg InSolution Caspase-8 Inhibitor II 218840 Z-IE(OMe)TD(OMe)-FMK a Yes No 8, Granzyme B 250 mg $88 Caspase-9 Inhibitor I 218761 Z-LE(OMe)HD(OMe)-FMK a Yes No 9 250 mg mg InSolution Caspase-9 Inhibitor I 218841 Z-LE(OMe)HD(OMe)-FMK a Yes No 9 250 mg $ 3 Caspase-9 Inhibitor II, Cell-Permeable 218776 Ac-AAVALLPAVLLALLAP- LEHD-CHO $88 $263 $ 3 $3 0 Yes Yes 9 mg $ 70 Caspase-9 Inhibitor III 218728 Ac-LEHD-CMK Yes No 9 mg $87 Caspase- 3 Inhibitor I 219005 Ac-LEED-CHO ‡ No Yes 3 mg $43 Caspase- 3 Inhibitor II 219009 Z-LE(OMe)E(OMe)D(OMe)- FMK a Yes No 3 250 mg mg CrmA, Recombinant PF122 — No — , Granzyme B 00 mg $5 0 Granzyme B Inhibitor I 368050 Z-AAD-CMK b Yes No Granzyme B mg $69 Granzyme B Inhibitor II 368055 Ac-IETD-CHO ‡ No Yes 8, Granzyme B mg $60 Granzyme B Inhibitor IV 368056 Ac-IEPD-CHO No Yes 8, Granzyme B mg $84 Group III Caspase Inhibitor I 368620 Z-A-E(OMe)-V-D(OMe)-FMK a Yes No 6, 8, 9, 0 mg $27 InSolution Q-VD-OPh, Non-Omethylated $83 $249 551476 Q-Val-Asp-CH2-Oph Yes No 3, 8, 9, 0, 2 mg $ 42 XIAP, Human, Recombinant, E. coli PF137 — No — 3, 7 50 mg $386 Key: a: FMK = Fluoromethyl ketone; b: CMK = Chloromethyl ketone; c: FAOM = 2,6-bis(trifluoromethyl) benzoyloxymethyl ketone; d: AOM = 2,6dimethylbenzoyloxy ketone; e: DCB = 2,6 dichlorobenzoyloxy; ‡: These aldehyde-based inhibitors may be cell-permeable, albeit to a lesser extent. Technical Support Phone 800 628 8470 E-mail calbiochem@emdbiosciences.com 65
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Inhibitor SourceBook Second Editio
Page 3 and 4:
Calbiochem • Inhibitor SourceBook
Page 5 and 6:
Page 7 and 8:
Akt (Protein Kinase B) Inhibitors,
Page 9 and 10:
Calmodulin-Dependent Protein Kinase
Page 11 and 12:
Casein Kinase (CK) Inhibitors Casei
Page 13 and 14:
Checkpoint Kinase Inhibitors Eukary
Page 15 and 16: Cyclin-Dependent Kinase (Cdk) Inhib
Page 21 and 22: Glycogen Synthase Kinase-3 (GSK-3)
Page 23 and 24: Glycogen Synthase Kinase Inhibitors
Page 25 and 26: c-Jun N-Terminal Kinase (JNK/SAP Ki
Page 27 and 28: Mitogen-Activated Protein (MAP) Kin
Page 29 and 30: MAP Kinase Inhibitors, continued Ca
Page 31 and 32: Myosin Light Chain Kinase (MLCK) In
Page 33 and 34: Phosphatidylinositol 3-Kinase (PI 3
Page 35 and 36: Calbiochem • Inhibitor SourceBook
Page 37 and 38: Protein Kinase A (PKA; cAMP-Depende
Page 39 and 40: Isozyme Specificities of Selected P
Page 41 and 42: Protein Kinase C (PKC) Inhibitors,
Page 47 and 48: Protein Tyrosine Kinase (PTK) Inhib
Page 57 and 58: Raf Kinase Inhibitors Raf kinases a
Page 59 and 60: Rho Kinase (ROCK) Inhibitors, conti
Page 61 and 62: Protein Phosphatase Inhibitors Calb
Page 63 and 64: Protein Phosphatase Inhibitors, con
Page 65: Apoptosis Caspase Inhibitors Activa
Page 69 and 70: Other Selected Inhibitors of Apopto
Page 73 and 74: DNA Methyltransferase Inhibitors DN
Page 75 and 76: Histone Acetylase and Deacetylase I
Page 77 and 78: Related Products Histone Deacetylas
Page 79 and 80: Nuclear Import/Export Inhibitors, c
Page 83 and 84: Telomerase Inhibitors, continued Ca
Page 85 and 86: Topoisomerase Related Inhibitors, c
Page 87 and 88: Lipid Signaling Acetyl-CoA Carboxyl
Page 89 and 90: Cyclooxygenase (COX) Inhibitors, co
Page 91 and 92: HMG-CoA (3-Hydroxy-3-Methylglutaryl
Page 93 and 94: Lipoxygenase (LOX) Inhibitors Lipox
Page 95 and 96: Phospholipase Inhibitors Several si
Page 97 and 98: Sphingomyelinase Inhibitors Ceramid
Page 99 and 100: Amyloidogenesis Inhibitors Calbioch
Page 101 and 102: Secretase Inhibitors Deposition of
Page 103 and 104: Secretase Inhibitors Calbiochem •
Page 107 and 108: Glutathione S-Transferase (GST) Inh
Page 109 and 110: Guanylate Cyclase Inhibitors, conti
Page 111 and 112: Characteristics of various forms of
Page 113 and 114: Nitric Oxide Synthase (NOS) Inhibit
Page 115 and 116: Proteases Anthrax Lethal Factor (LF
Page 117 and 118:
the ratio of active (76 kDa) to ina
Page 119 and 120:
Collagenase Inhibitors (Also see Ma
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Matrix Metalloproteinase (MMP) Inhi
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Matrix Metalloproteinase Inhibitors
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Tissue Inhibitors of Matrix Metallo
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Protease Inhibitors The proper func
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Protease Inhibitors, continued Calb
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Protease Inhibitors, continued Calb
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Protease Inhibitors, continued Sele
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Protease Inhibitor Cocktails, conti
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N Animal-Free Protease Inhibitor Co
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Proteasome and Ubiquitination Pathw
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Transmembrane receptors of various
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Angiotensin-Converting Enzyme (ACE)
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ATPase Inhibitors, continued Calbio
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Page 149 and 150:
Inhibitors of Glycoprotein Processi
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Heat Shock Protein Inhibitors Heat
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Inhibitors of Mitochondrial Functio
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NF-kB Activation Inhibitors NF-kB,
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NF-kB Activation Inhibitors, contin
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Phosphodiesterase (PDE) Inhibitors
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Plasminogen Activator Inhibitors Ti
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Protein Synthesis Inhibitors, conti
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Sonic Hedgehog Signaling Inhibitors
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Why can’t I make serial dilutions
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Calpastatin, Human, Recombinant, Do
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InSolution Microcystin-LR, Microcys
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RNA Polymerase III Inhibitor ......
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324875 ............................
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Trademarks CALBIOCHEM®
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Your #1 Resource for Inhibitors! We
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