Inhibitor SourceBook™ Second Edition

Proteases
Protease Inhibitors, continued
Product Cat. No. Comments Size Price
Kininogen, High Molecular Weight,
Single Chain, Human Plasma
Kininogen, High Molecular
Weight, Two Chain, Human
Plasma
Kininogen, Low Molecular
Weight, Human Plasma
422686 (HMWK, Fitzgerald factor)
Synthesized as a single polypeptide chain in the liver and secreted into
the plasma, where it complexes with prekallikrein and factor XI. A nonenzymatic
cofactor of the contact activation system.
422688 Two-chain kinin-free kininogen prepared by kallikrein digestion of
kininogen, which is then re-purified to remove traces of kallikrein. Binds
to papain and cathepsin S with high affinity, exhibiting 2: binding
stoichiometry.
422685 (L-Kininogen)
A multi-functional plasma protein that functions as a cysteine protease
inhibitor. A non-enzymatic cofactor of the contact activation system.
Leuhistin 432077 [((2R,3S)-3-Amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methyl)-5methylhexanoic
Acid]
A microbial product that competitively inhibits aminopeptidase M
(K = 230 nM).
i
Leupeptin, Hemisulfate 108975 (Ac-LLR-CHO, ½H SO ; Ac-Leu-Leu-Arginal)
2 4
A reversible inhibitor of trypsin-like proteases and cysteine proteases.
a 2 -Macroglobulin, Human Plasma 441251 (a 2 M; a 2 MG)
A broad-range irreversible protease inhibitor. Forms “trap” around most
proteases.
DL-2-Mercaptomethyl-3guanidinoethylthiopropanoic
Acid
a -PDX, Human, Recombinant,
E. coli
445825 (Plummer’s Inhibitor)
A potent and reversible inhibitor of human plasma carboxypeptidase N
(K i = 2 nM). Also inhibits the hydrolysis of bradykinin.
126850 (a 1 -Antitrypsin Portland)
Recombinant protein derived from the bioengineered human a -antitrypsin
gene fused to a His•Tag® sequence and a FLAG-tag. Contains
a minimal furin consensus sequence, RXXR, that effectively blocks the
furin-dependent processing of protein precursors (K i = 600 pM).
Pepstatin A, Synthetic 516481 (Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4amino-3-hydroxy-6-methylheptanoic
Acid; Iva-Val-Val-Sta-Ala-Sta)
A reversible inhibitor of aspartic proteases. Inhibits cathepsin D,
pepsin, and renin.
Phenylmethylsulfonyl Fluoride 52332 (Benzylsulfonyl Fluoride; PMSF)
An irreversible inhibitor of serine proteases. Its mechanism of action
is analogous to that of diisopropylfluorophosphate. PMSF causes
sulfonylation of the active-site serine residues.
Phosphoramidon, Disodium Salt 525276 [N-a-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan,
2Na]
A highly specific inhibitor of thermolysin. Inhibits the conversion of big
endothelin- to endothelin (IC = 4.6 mM).
50
PPACK, Dihydrochloride 520222 (D-Phe-Pro-Arg-Chloro-methylketone, 2HCl)
A potent and selective inhibitor of thrombin. Specifically alkylates an
active center histidine and thus is classified as an affinity label for
thrombin.
PPACK Dihydrochloride,
Biotinylated
520224 (Biotin-X-D-Phe-Pro-Arg-chloromethylketone, 2HCl)
Biotin-X-analog of Cat. No. 520222. Specific probe for active serine
proteases. Potent inhibitor of thrombin and tissue plasminogen activator
(tPA). Useful for Western blot analyses of Factor VIIa, Factor XIa,
thrombin, and tPA.
mg $366
mg $333
00 mg $2 6
5 mg $29
5 mg
0 mg
25 mg
50 mg
00 mg
mg
0 mg
30 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem
$46
$69
$ 37
$238
$394
$73
$487
00 mg $83
2.5 mg $372
5 mg
25 mg
00 mg
g
5 g
25 g
$38
$ 3
$334
$28
$52
$ 56
5 mg $ 44
5 mg
25 mg
$ 48
$504
mg $380
PPACKII, Trifluoroacetate Salt 520219 A potent and irreversible inhibitor of plasma and glandular kallikreins. 0 mg $ 65