Inhibitor SourceBook™ Second Edition

Topoisomerase Related Inhibitors, continued
Calbiochem • Inhibitor SourceBook
Cell Division/Cell Cycle/Cell Adhesion
Product Cat. No. Comments Size Price
Doxorubicin,
Hydrochloride
324380 (Adriamycin; 14-Hydroxydaunomycin, HCl)
An anti-tumor antibiotic and a highly effective myotoxin that inhibits
topoisomerase II (IC 50 = 00 nM).
Ellagic Acid, Dihydrate 324683 (4,4´,5,5´,6,6´-Hexahydroxydiphenic Acid 2,6,2´,6´-Dilactone)
A potent antioxidant with anti-mutagenic and anti-carcinogenic properties.
Inhibits DNA topoisomerases I and II (IC 50 = .8 mM and 2. mM, respectively).
Acts as a potent inhibitor of PKA catalytic subunit (cAK) and PKC (IC 50 = 2 mM and
8 mM respectively).
Ellipticine 324688 (5,11-Dimethyl-6H-pyrido[4,3-b]carbazole)
A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates
topoisomerase II-mediated DNA breakage.
Epirubicin
Hydrochloride
Etoposide 341205 (VP-16)
324905 (4´-Epidoxorubicin, HCl)
A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor
actions are mediated by targeting topoisomerase II.
A topoisomerase II inhibitor (IC 50 = 59.2 mM) that induces apoptosis in mouse
thymocytes and in HL-60 human leukemia cells.
Etoposide Phosphate 341206 A water-soluble derivative of the topoisomerase II inhibitor, etoposide
(Cat. No. 34 205).
Genistein 345834 (4´,5,7-Trihydroxyisoflavone)
An inhibitor of protein tyrosine kinases (IC 50 = 2.6 mM for EGFR tyrosine kinase)
that also inhibits topoisomerase II activity in vitro.
Merbarone 445800 [NSC-336628; 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid]
An anticancer drug that inhibits the catalytic activity of DNA topoisomerase II
(topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes
(IC 50 = 20 mM for purified mammalian topoisomerase II versus IC 50 ~200 mM for
topoisomerase I).
Suramin, Sodium Salt 574625 A competitive inhibitor of reverse transcriptase that also blocks the activity of
topoisomerase I and II.
Topotecan,
Hydrochloride
614800 {9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin, HCl}
A water-soluble, semi-synthetic derivative of camptothecin (Cat. No. 208925).
A potent DNA topoisomerase I inhibitor. Has been shown to exhibit antitumor
activity against several forms of cancer.
0 mg $ 49
500 mg $57
0 mg $64
5 mg $
25 mg $4
5 mg $67
20 mg
50 mg
$73
$ 46
25 mg $77
50 mg
200 mg
$34
$
mg $ 69
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