Inhibitor SourceBook™ Second Edition

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Other Inhibitors of Biological Interest Adenylate Cyclase Inhibitors, continued Product Cat. No. Comments Size Price InSolution MANT-GppNHp 444168 {mant-GMPPNP; 2´/3´-O-(N-Methylanthraniloyl)-guanosine- 5´-[(b,g)-imido]triphosphate, Triethylammonium Salt; 2´/3´-O- (N-Methylanthraniloyl)-b,g-imidoguanosine-5´-triphosphate, Triethylammonium Salt} Acts as a potent, competitive inhibitor of adenylyl cyclase (AC; K i = 6 nM and 55 nM in forskolin/Mn 2+ -stimulated AC in S49 cyc - membranes and insect cell membranes, respectively). Supplied as a 5 mM solution in H 2 O. InSolution MANT-GTPgS 444169 [2´/3´-O-(N-Methylanthraniloyl)-guanosine-5´-(g-thio)triphosphate, Triethylammonium Salt; 2´/3´-O-(N-Methylanthraniloyl)-gthioguanosine-5´-triphosphate, Triethylammonium Salt; mGTPgS] Acts as a potent, competitive inhibitor of adenylyl cyclase (AC; K i = 53 nM in forskolin/Mn 2+ -stimulated AC in S49 cyc - membranes). Supplied as a 5 mM solution in H 2 O. MDL- 2,330A, Hydrochloride 444200 [cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine, HCl] A cell-permeable, irreversible inhibitor of adenylate cyclase (IC 50 = 250 mM). 50 ml $220 50 ml $220 mg $38 Melittin 444605 Inhibits adenylyl cyclase activity in synaptic membranes. 250 mg $67 SQ 22536 568500 [9-(Tetrahydro-2´-furyl)adenine] A cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulated AC activity (IC 50 = 200 mM). 5 mg $ 0 40 Orders Phone 800 854 34 7 Calbiochem • Inhibitor SourceBook Fax 800 776 0999 Web www.emdbiosciences.com/calbiochem
Angiotensin-Converting Enzyme (ACE) Inhibitors The renin-angiotensin system plays an important role in electrolyte balance and fluid regulation. ACE inhibitors have become important clinical tools in the management of hypertension. They block the activation of the renin-aldosterone system, thereby reducing peripheral Angiotensin-Converting Enzyme (ACE) Inhibitors Calbiochem • Inhibitor SourceBook Other Inhibitors of Biological Interest vascular resistance. ACE inhibitors also improve myocardial oxygen consumption and cardiac output and moderate left ventricular and vascular hypertrophy. Product Cat. No. Comments Size Price Captopril 211875 ([2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline; SQ-14225) A competitive inhibitor of angiotensin converting enzyme (IC 50 = 23–35 nM). TAPI-2 579052 {N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-tbutyl-alanyl-L-alanine, 2-aminoethyl Amide; TNF-a Protease Inhibitor- 2} ATPase Inhibitors ATPase Inhibitors A hydroxamate-based inhibitor of MMPs and TACE. Also acts as a weak inhibitor of angiotensin converting enzyme (IC 50 = 8 mM). DL-Thiorphan 598510 N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC 50 = 2. nM for neutral endopeptidase-NEP). Reported to inhibit the activity of angiotensin-converting enzyme (ACE) at much higher concentrations (IC 50 = 4 mM); however, it does not affect the activity of endothelinconverting enzyme. Aromatase Inhibitors Aromatase Inhibitors More online... www.calbiochem.com/inhibitors/ACE g $44 mg $262 0 mg $ 95 Product Cat. No. Comments Size Price Aromatase Inhibitor I 182540 A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC 50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 7a-hydroxylase. More online... www.calbiochem.com/inhibitors/ATPase Product Cat. No. Comments Size Price Adenosine 1160 Exerts a biphasic effect on Ca 2+ - Mg 2+ -ATPase activity. Inhibits the activity at ~ 00 nM levels. Amiloride, Hydrochloride 129876 A potent and specific inhibitor of trans-membrane Na + entry and Na + /K + ATPase. Diminishes the urinary transepithelial potential difference and short-circuit current (IC 50 = 300 nM). Atrial Natriuretic Factor -28, Rat 05-23-0301 (rANF; SLRRSSCFGGRIDRIGAQSGLGCNSFRY) Reduces the activity of Na + -K + -ATPase in rat kidney and activates neuronal guanylate cyclase. 0 g 00 g mg $ 06 $3 $ 5 00 mg $4 00 mg $57 Technical Support Phone 800 628 8470 E-mail calbiochem@emdbiosciences.com 4
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Inhibitor SourceBook Second Editio
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Calbiochem • Inhibitor SourceBook
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Akt (Protein Kinase B) Inhibitors,
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Calmodulin-Dependent Protein Kinase
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Casein Kinase (CK) Inhibitors Casei
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Checkpoint Kinase Inhibitors Eukary
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Cyclin-Dependent Kinase (Cdk) Inhib
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Glycogen Synthase Kinase-3 (GSK-3)
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Glycogen Synthase Kinase Inhibitors
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c-Jun N-Terminal Kinase (JNK/SAP Ki
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Mitogen-Activated Protein (MAP) Kin
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MAP Kinase Inhibitors, continued Ca
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Myosin Light Chain Kinase (MLCK) In
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Phosphatidylinositol 3-Kinase (PI 3
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Protein Kinase A (PKA; cAMP-Depende
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Isozyme Specificities of Selected P
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Protein Kinase C (PKC) Inhibitors,
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Protein Tyrosine Kinase (PTK) Inhib
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Raf Kinase Inhibitors Raf kinases a
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Rho Kinase (ROCK) Inhibitors, conti
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Protein Phosphatase Inhibitors Calb
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Protein Phosphatase Inhibitors, con
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Apoptosis Caspase Inhibitors Activa
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Caspase Inhibitors, continued Produ
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Other Selected Inhibitors of Apopto
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DNA Methyltransferase Inhibitors DN
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Histone Acetylase and Deacetylase I
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Related Products Histone Deacetylas
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Nuclear Import/Export Inhibitors, c
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Telomerase Inhibitors, continued Ca
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Topoisomerase Related Inhibitors, c
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Lipid Signaling Acetyl-CoA Carboxyl
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Cyclooxygenase (COX) Inhibitors, co
Page 91 and 92: HMG-CoA (3-Hydroxy-3-Methylglutaryl
Page 93 and 94: Lipoxygenase (LOX) Inhibitors Lipox
Page 95 and 96: Phospholipase Inhibitors Several si
Page 97 and 98: Sphingomyelinase Inhibitors Ceramid
Page 99 and 100: Amyloidogenesis Inhibitors Calbioch
Page 101 and 102: Secretase Inhibitors Deposition of
Page 103 and 104: Secretase Inhibitors Calbiochem •
Page 105 and 106: Calbiochem • Inhibitor SourceBook
Page 107 and 108: Glutathione S-Transferase (GST) Inh
Page 109 and 110: Guanylate Cyclase Inhibitors, conti
Page 111 and 112: Characteristics of various forms of
Page 113 and 114: Nitric Oxide Synthase (NOS) Inhibit
Page 115 and 116: Proteases Anthrax Lethal Factor (LF
Page 117 and 118: the ratio of active (76 kDa) to ina
Page 119 and 120: Collagenase Inhibitors (Also see Ma
Page 121 and 122: Matrix Metalloproteinase (MMP) Inhi
Page 123 and 124: Matrix Metalloproteinase Inhibitors
Page 125 and 126: Tissue Inhibitors of Matrix Metallo
Page 127 and 128: Protease Inhibitors The proper func
Page 129 and 130: Protease Inhibitors, continued Calb
Page 131 and 132: Protease Inhibitors, continued Calb
Page 133 and 134: Protease Inhibitors, continued Sele
Page 135 and 136: Protease Inhibitor Cocktails, conti
Page 137 and 138: N Animal-Free Protease Inhibitor Co
Page 139 and 140: Proteasome and Ubiquitination Pathw
Page 141: Transmembrane receptors of various
Page 145 and 146: ATPase Inhibitors, continued Calbio
Page 147 and 148: Calbiochem • Inhibitor SourceBook
Page 149 and 150: Inhibitors of Glycoprotein Processi
Page 151 and 152: Heat Shock Protein Inhibitors Heat
Page 153 and 154: Inhibitors of Mitochondrial Functio
Page 155 and 156: NF-kB Activation Inhibitors NF-kB,
Page 157 and 158: NF-kB Activation Inhibitors, contin
Page 159 and 160: Phosphodiesterase (PDE) Inhibitors
Page 161 and 162: Plasminogen Activator Inhibitors Ti
Page 163 and 164: Protein Synthesis Inhibitors, conti
Page 165 and 166: Sonic Hedgehog Signaling Inhibitors
Page 167 and 168: Why can’t I make serial dilutions
Page 169 and 170: Calpastatin, Human, Recombinant, Do
Page 171 and 172: InSolution Microcystin-LR, Microcys
Page 173 and 174: RNA Polymerase III Inhibitor ......
Page 175 and 176: 324875 ............................
Page 177 and 178: Trademarks CALBIOCHEM®
Page 179 and 180: Your #1 Resource for Inhibitors! We
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