Inhibitor SourceBook™ Second Edition

More documents

Recommendations

Info

Cell Division/Cell Cycle/Cell Adhesion Histone Acetylase and Deacetylase Inhibitors, continued Product Cat. No. Comments Size Price Histone Deacetylase 382148 (m-Carboxycinnamic Acid bis-Hydroxamide; CBHA) 5 mg — Inhibitor II A second-generation hybrid polar agent that has been shown to inhibit the activities of histone deacetylase (HDAC) and 3 (ID = 0 nM and 7 nM, 50 respectively) in MEL DS 9/Sc9 cells. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Not available for sale in the United States. Histone Deacetylase 382149 [4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide; N-Hydroxy-7-(4-dimethy mg $93 Inhibitor III laminobenzoyl)aminoheptanamide; M344] An amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC = 40 nM for rat liver HDAC and IC = 00 nM for maize HDAC). 50 50 5 mg $284 ITSA 419840 [N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide; Inhibitor of Trichostatin A 1] A cell-permeable benzotriazole amide that can be used to counteract Trichostatin A-induced cell cycle arrest, histone acetylation, and transcription activation. 25 mg $79 mg $87 5 mg $297 Oxamflatin 499700 {(2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic Acid} An aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian histone deacetylase (IC 50 = 5.7 nM). Acts as a ligand for the enzyme active site metal ion. SBHA 559418 (Suberic Bishydroxamate; Suberoyl Bishydroxamic Acid) A histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC and HDAC3 activities with a similar potency (ID ~250–300 nM). 50 Not available for sale in the United States. Scriptaid 565730 {CGK1026; 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide A relatively non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Causes over 00-fold increase in histone acetylation in PANC- cells at 6 mM. Sirtinol 566320 {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; Sir Two Inhibitor Naphthol} A cell-permeable, specific, and a direct inhibitor of the sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC . Reported to block Sir2p transcriptional silencing activity in vivo (IC = 25 mM) and NAD-dependent 50 HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC = 68 mM and 38 mM, respectively). 50 N InSolution Sirtinol 566321 {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; Sir Two Inhibitor Naphthol} A 0 mM ( mg/254 ml) solution of Sirtinol (Cat. No. 566320) in DMSO. Splitomicin 567750 (1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one) A cell-permeable, selective inhibitor of NAD + -dependent histone deacetylase activity of Sir2 protein (IC = 60 mM). It creates a conditional phenocopy of a Sir2 50 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Trichostatin A, Streptomyces sp. N InSolution Trichostatin A, Streptomyces sp. Valproic Acid, Sodium Salt 647925 (4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid; TSA) A potent and reversible inhibitor of histone deacetylase. 647926 A 0 mM (500 mg/ 65 ml) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO. 676380 (2-Propylpentanoic Acid, Na) A cell-permeable, short-chain fatty acid that inhibits histone deacetylase (IC = 400 mM for HDAC ). Induces differentiation and inhibits proliferation 50 of cell lines derived from human malignant gliomas. 00 mg — 5 mg $96 5 mg $ 6 mg $58 5 mg $ 03 mg $ 56 500 mg $90 5 g $48 74 Orders Phone 800 854 34 7 Calbiochem • Inhibitor SourceBook Fax 800 776 0999 Web www.emdbiosciences.com/calbiochem
Related Products Histone Deacetylase Activity Assay Kit, Colorimetric A rapid, two-step assay that measures histone deacetylase (HDAC) activity in cell lysates. Deacetylation by HDAC results in a sensitized substrate that, when treated with the lysine developer, produces a chromophore that can be measured at 400 or 405 nm by a spectrophotometer or a plate reader. kit = 00 assays Cat. No. 382166 1 kit $372 N Histone Deacetylase, Human, Recombinant, S. frugiperda Recombinant human histone deacetylase 3 (HDAC3) expressed in insect cells using a baculovirus expression system. HDAC3 is a class I histone deacetylase that regulates gene expression by deacetylation of histones and nonhistone proteins. It is suggested that HDACs play an important role in transcriptional regulation, cell cycle progression and activation, and biological processes in eukaryotes that involve chromatin. Cat. No. 382169 5000 U $345 Histone Deacetylase, Rat Liver An enzymatically active, partially purified, histone deacetylase from rat liver. Useful in radioactive and in nonradioactive assays of histones. Can be useful to test the potency of HDAC inhibitors. Cat. No. 382165 2 ml $284 Calbiochem • Inhibitor SourceBook Cell Division/Cell Cycle/Cell Adhesion Histone Deacetylase Activity Assay Kit, Fluorometric A rapid, two-step assay that measures histone deacetylase (HDAC) activity in cell lysates. Deacetylation by HDAC results in a sensitized substrate that, when treated with the lysine developer, produces a fluorophore that can be measured at 440-460 nm by a fluorometer or a fluorescence plate reader. kit = 00 assays Cat. No. 382167 1 kit $350 Histone Deacetylase HD2, Maize An enzymatically active, highly purified, histone deacetylase (HDAC) from maize embryos. Shown to be useful for screening of HDAC Inhibitors (IC 50 = 7.2 nM for TSA, 0 nM for Trapoxin, 50 nM for SAHA, and 0 nM for HC-Toxin). Reported to be a multimer-protein complex that dissociates into three polypeptides (p39, p42, and p45) upon denaturation. Cat. No. 382168 500 ml $303 To download free Interactive Pathways screensavers visit us at www.calbiochem.com/screensavers Technical Support Phone 800 628 8470 E-mail calbiochem@emdbiosciences.com 75
Page 1 and 2:
Inhibitor SourceBook Second Editio
Page 3 and 4:
Calbiochem • Inhibitor SourceBook
Page 5 and 6:
Page 7 and 8:
Akt (Protein Kinase B) Inhibitors,
Page 9 and 10:
Calmodulin-Dependent Protein Kinase
Page 11 and 12:
Casein Kinase (CK) Inhibitors Casei
Page 13 and 14:
Checkpoint Kinase Inhibitors Eukary
Page 15 and 16:
Cyclin-Dependent Kinase (Cdk) Inhib
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Glycogen Synthase Kinase-3 (GSK-3)
Page 23 and 24:
Glycogen Synthase Kinase Inhibitors
Page 25 and 26: c-Jun N-Terminal Kinase (JNK/SAP Ki
Page 27 and 28: Mitogen-Activated Protein (MAP) Kin
Page 29 and 30: MAP Kinase Inhibitors, continued Ca
Page 31 and 32: Myosin Light Chain Kinase (MLCK) In
Page 33 and 34: Phosphatidylinositol 3-Kinase (PI 3
Page 35 and 36: Calbiochem • Inhibitor SourceBook
Page 37 and 38: Protein Kinase A (PKA; cAMP-Depende
Page 39 and 40: Isozyme Specificities of Selected P
Page 41 and 42: Protein Kinase C (PKC) Inhibitors,
Page 47 and 48: Protein Tyrosine Kinase (PTK) Inhib
Page 57 and 58: Raf Kinase Inhibitors Raf kinases a
Page 59 and 60: Rho Kinase (ROCK) Inhibitors, conti
Page 61 and 62: Protein Phosphatase Inhibitors Calb
Page 63 and 64: Protein Phosphatase Inhibitors, con
Page 65 and 66: Apoptosis Caspase Inhibitors Activa
Page 67 and 68: Caspase Inhibitors, continued Produ
Page 69 and 70: Other Selected Inhibitors of Apopto
Page 73 and 74: DNA Methyltransferase Inhibitors DN
Page 75: Histone Acetylase and Deacetylase I
Page 79 and 80: Nuclear Import/Export Inhibitors, c
Page 83 and 84: Telomerase Inhibitors, continued Ca
Page 85 and 86: Topoisomerase Related Inhibitors, c
Page 87 and 88: Lipid Signaling Acetyl-CoA Carboxyl
Page 89 and 90: Cyclooxygenase (COX) Inhibitors, co
Page 91 and 92: HMG-CoA (3-Hydroxy-3-Methylglutaryl
Page 93 and 94: Lipoxygenase (LOX) Inhibitors Lipox
Page 95 and 96: Phospholipase Inhibitors Several si
Page 97 and 98: Sphingomyelinase Inhibitors Ceramid
Page 99 and 100: Amyloidogenesis Inhibitors Calbioch
Page 101 and 102: Secretase Inhibitors Deposition of
Page 103 and 104: Secretase Inhibitors Calbiochem •
Page 107 and 108: Glutathione S-Transferase (GST) Inh
Page 109 and 110: Guanylate Cyclase Inhibitors, conti
Page 111 and 112: Characteristics of various forms of
Page 113 and 114: Nitric Oxide Synthase (NOS) Inhibit
Page 115 and 116: Proteases Anthrax Lethal Factor (LF
Page 117 and 118: the ratio of active (76 kDa) to ina
Page 119 and 120: Collagenase Inhibitors (Also see Ma
Page 121 and 122: Matrix Metalloproteinase (MMP) Inhi
Page 123 and 124: Matrix Metalloproteinase Inhibitors
Page 125 and 126: Tissue Inhibitors of Matrix Metallo
Page 127 and 128:
Protease Inhibitors The proper func
Page 129 and 130:
Protease Inhibitors, continued Calb
Page 131 and 132:
Protease Inhibitors, continued Calb
Page 133 and 134:
Protease Inhibitors, continued Sele
Page 135 and 136:
Protease Inhibitor Cocktails, conti
Page 137 and 138:
N Animal-Free Protease Inhibitor Co
Page 139 and 140:
Proteasome and Ubiquitination Pathw
Page 141 and 142:
Transmembrane receptors of various
Page 143 and 144:
Angiotensin-Converting Enzyme (ACE)
Page 145 and 146:
ATPase Inhibitors, continued Calbio
Page 147 and 148:
Page 149 and 150:
Inhibitors of Glycoprotein Processi
Page 151 and 152:
Heat Shock Protein Inhibitors Heat
Page 153 and 154:
Inhibitors of Mitochondrial Functio
Page 155 and 156:
NF-kB Activation Inhibitors NF-kB,
Page 157 and 158:
NF-kB Activation Inhibitors, contin
Page 159 and 160:
Phosphodiesterase (PDE) Inhibitors
Page 161 and 162:
Plasminogen Activator Inhibitors Ti
Page 163 and 164:
Protein Synthesis Inhibitors, conti
Page 165 and 166:
Sonic Hedgehog Signaling Inhibitors
Page 167 and 168:
Why can’t I make serial dilutions
Page 169 and 170:
Calpastatin, Human, Recombinant, Do
Page 171 and 172:
InSolution Microcystin-LR, Microcys
Page 173 and 174:
RNA Polymerase III Inhibitor ......
Page 175 and 176:
324875 ............................
Page 177 and 178:
Trademarks CALBIOCHEM®
Page 179 and 180:
Your #1 Resource for Inhibitors! We
show all

Inhibitor SourceBook™ Second Edition

Create successful ePaper yourself

Delete template?

Save as template?