Inhibitor SourceBook™ Second Edition

Proteases
Protease Inhibitors, continued
Product Cat. No. Comments Size Price
Cathepsin L Inhibitor IV 219433 (1-Naphthalenesulfonyl-IW-CHO)
A potent inhibitor of cathepsin L (IC 50 = .9 nM). Also inhibits the
release of Ca 2+ and hydroxyproline from bone in an in vitro bone culture
system.
Cathepsin L Inhibitor V 219435 [Z-FY(OtBu)-COCHO]
A slow, tight-binding reversible inhibitor of recombinant human
cathepsin L (K i = 600 pM). Exhibits over 360-fold greater selectivity for
cathepsin L compared to cathepsin B (K i = 2 4 nM).
Cathepsin L Inhibitor VI 219495 [N-(4-Biphenylacetyl)-S-methylcysteine-(D)-Arg-Phe-b-phenethylamide;
Compound 7]
An end-protected tripeptide that acts as a highly selective, potent, and
reversible inhibitor of human recombinant cathepsin-L (K i = 9 nM).
Cathepsin S Inhibitor 219393 (Z-FL-COCHO)
A slow, tight-binding reversible inhibitor of recombinant cathepsin S
(K i = 85 pM). Exhibits over 4 0-fold greater selectivity for cathepsin S
than for cathepsin B (K i = 76 nM).
Cathepsin/Subtilisin Inhibitor 219420 (Boc-VF-NHO-Bz-pCl)
Inhibits members of the cysteine protease family including cathepsin
L, and members of the serine protease family including subtilisin
Carlsberg and thermitase.
Chymostatin 230790 {[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)pyrimidyl]-(S)-glycyl-[A
= Leu; B = Val; or C = Ile]-phenylalaninal}
A reversible serine and cysteine protease inhibitor. Inhibits
chymotrypsin-like serine proteases.
Chymotrypsin Inhibitor I, Potato 230906 A pentamer consisting of 5–8 kDa monomeric subunits. Each
subunit inhibits one molecule of chymotrypsin. Suppresses radiation
transformation of C3H/ 0T /2 cells in vitro.
Cystatin, Egg White 240891 (Ovocystatin)
A competitive and reversible cysteine protease inhibitor.
3,4-Dichloroisocoumarin 287815 A potent irreversible inhibitor of serine proteases. Reacts with
serine proteases to release acyl chloride moiety that can acylate
another active site residue. Has no action on thiol proteases and
metalloproteases.
Diisopropylfluorophosphate 30967 (DFP)
A potent irreversible inhibitor of serine proteases. Also irreversibly
inactivates acetylcholinesterase.
Dipeptidylpeptidase II Inhibitor 317621 (Dab-Pip; L-2,4-Diaminobutyrylpiperidinamide; DPP II Inhibitor)
A potent and highly specific inhibitor of dipeptidylpeptidase II
(IC 50 = 30 nM). Displays ~7700-fold greater selectivity for human
seminal fluid DPP II compared to DPP IV (IC 50 > mM).
Dipeptidylpeptidase IV Inhibitor I 416200 (Diprotin A)
A serine protease inhibitor. Inhibits both endo- and exopeptidase
activities of DPP IV.
Dipeptidylpeptidase IV Inhibitor II 317638 A reversible inhibitor of dipeptidyl peptidase II (K = 3.8 mM) and
i
dipeptidyl peptidase IV (K = .0 mM).
i
,5-Dansyl-Glu-Gly-Arg
Chloromethyl Ketone,
Dihydrochloride
251700 (1,5-DNS-GGACK, 2HCl)
An effective irreversible inhibitor of Factor Xa (IC 50 = 00 nM) and
urokinase.
E-64 Protease Inhibitor 324890 An irreversible cysteine protease inhibitor that has no action on
cysteine residues in other proteins. Specific active site titrant.
Also inhibits the cysteine protease activity of GP 57/5 antigen of
trypanosoma (IC = 00 nM).
50
E-64, Immobilized 324891 An immobilized form of the cysteine protease inhibitor E-64
(Cat. No. 324890) covalently attached to hydrophilic acrylic beads via
a 4-carbon spacer. Useful to affinity-precipitate cathepsins and other
functionally related proteins from cell lysates or tissue extracts.
Each set contains 25 mg of E-64 immobilized beads and 25 mg of
control beads.
mg $72
mg $84
5 mg $87
mg $84
mg $ 03
28 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem
5 mg
0 mg
25 mg
$60
$ 08
$22
0 mg $63
500 mg $305
0 mg $ 30
g $266
0 mg $84
5 mg $ 22
mg $ 00
5 mg $20
mg
5 mg
25 mg
$34
$ 35
$509
set $ 73