Inhibitor SourceBook™ Second Edition

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Apoptosis Caspase Inhibitors, continued Caspase Inhibitor Set I A set of 3 separate vials. Each set contains mg each of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264 55); Caspase- Inhibitor I, Ac-YVAD-CHO (Cat. No. 4000 0); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 6276 0). Cat. No. 235429 1 set $398 Caspase Inhibitor Set II A set of 8 separate vials of cell-permeable, irreversible caspase inhibitors. Each set contains 250 µg each of Caspase- Inhibitor VI, Z-YVAD-FMK (Cat. No. 2 8746); Caspase-2 Inhibitor I, Z-VDVAD- FMK (Cat. No. 2 8744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264 55); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 2 8753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 2 8757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 2 876 ); and Caspase Inhibitor III, Boc-D-FMK (Cat. No. 2 8745). Cat. No. 218772 1 set $603 Granzyme Inhibitors Product Cat. No. Comments Size Price Caspase-8 Inhibitor I, Cell-Permeable 218773 (granzyme B Inhibitor II, Cell-permeable; IETD-CHO, Cell-permeable) A potent, cell-permeable and reversible inhibitor of caspase-8 (FLICE, MACH, Mch5) and granzyme B. Caspase-8 Inhibitor II 218759 [granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK] A potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. InSolution Caspase-8 Inhibitor II 218840 [granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK] A 5 mM (250 mg/76 ml) solution of caspase-8 Inhibitor II (Cat. No. 2 8759) in anhydrous DMSO. mg $ 70 66 Orders Phone 800 854 34 7 Calbiochem • Inhibitor SourceBook Fax 800 776 0999 Web www.emdbiosciences.com/calbiochem 250 mg mg $88 $263 250 mg $88 CrmA, Recombinant PF122 An inhibitor of caspase- and granzyme B. 00 mg $5 0 Granzyme B Inhibitor I 368050 (Z-AAD-CMK) A weak inhibitor of human and murine granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID 50 = 300 nM). Granzyme B Inhibitor II 368055 (Ac-IETD-CHO; Caspase-8 Inhibitor I) A potent, reversible inhibitor of granzyme B and caspase-8. Granzyme B Inhibitor IV 368056 (Ac-IEPD-CHO; Caspase-8 inhibitor III) A reversible inhibitor of granzyme B that also inhibits caspase-8. More online... www.calbiochem.com/inhibitors/granzyme Caspase Inhibitor Set III A set of 8 separate vials. Each set contains a ready-to-use DMSO solution of cell-permeable, irreversible inhibitors of various members of the caspase-family proteases. Contains 25 µl (2 mM) each of Caspase- Inhibitor VI, Z-YVAD-FMK (Cat. No. 2 8746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 2 8744); Caspase-3 Inhibitor II, Z-DEVD- FMK (Cat. No. 264 55); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 2 8753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 2 8757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 2 876 ); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 6276 0). Cat. No. 218806 1 set $582 Caspase Inhibitor Set IV A set of 6 separate vials. Each set contains a ready-to-use solution of cellpermeable caspase inhibitors and an apoptosis inducer. Contains 25 µl of a 0 mM solution in DMSO of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264 55); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No 2 876 ); general caspase inhibitor, Z-VAD-FMK (Cat. No. 6276 0); the negative control Z-FA-FMK (Cat. No. 342000), and an aqueous solution ( 00 µl, 0.5 µM) of an apoptosis inducer, Doxorubicin, Hydrochloride (Cat. No. 324380). Cat. No. 218825 1 set $325 mg $69 mg $60 mg $84
Other Selected Inhibitors of Apoptosis Calbiochem • Inhibitor SourceBook Apoptosis Product Cat. No. Comments Size Price Apoptosis Inhibitor 178488 [M50054; 2,2´-Methylenebis(1,3-cyclohexanedione)] A cell-permeable inhibitor of apoptosis induction (IC 50 = 283 mM in FasL-stimulated WC8 cells, 550 mM in etoposide-stimulated U937 cells). The anti-apoptotic effects are attributed to the inhibition of caspase-3 activation (IC 50 = 334 mM in etoposidestimulated U937 cells). Apoptosis Inhibitor II, NS3694 178494 (NS3694) A cell-permeable compound that specifically prevents the active ~700 kDa apoptosome complex formation triggered by cytochrome c release. Protects against apoptosomemediated caspase activation and cell death. Bax Channel Blocker 196805 [(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, bis TFA] A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 mM) by inhibiting Bax channel-forming activity (IC 50 = 520 nM in a liposome channel assay). Bax-Inhibiting Peptide, V5 Bax-Inhibiting Peptide, Negative Control Fas/FasL Antagonist, Kp7-6 Humanin, Human, Synthetic Omi/HtrA2 Protease Inhibitor, Ucf- 0 196810 (BIP-V5; H-VPMLK-OH) A cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection. Functions as effectively as the Caspase Inhibitor VI (Z-VAD-FMK; Cat. No. 2 9007) for Bax-mediated apoptosis (~50–200 mM). 196811 (BIP-NC; H-IPMIK-OH) A cell-permeable mutated analog of the Bax-Inhibiting Peptide, V5 (Cat. No. 968 0) that serves as a negative control. Does not suppress Bax-mediated apoptosis (~200 mM). 341291 (H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide]; Kp7-6) Specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO- ) with comparable affinity (K = .2 and 3.2 mM, d respectively). 400140 (H-MAPRGFSCLLLLTSEIDLPVKRRA-OH; HN) An anti-apoptotic peptide that when expressed intracellularly, offers protection against neuronal apoptosis induced by presenilin and APP mutants associated with familial Alzheimer’s disease (AD). Reduces cytochrome c release in vitro by directly binding to Bax (K ~2 nM). d 496150 {High Temperature Requirement A2 Inhibitor I; 5-[5-(2-Nitrophenyl)furfurylidine]-1,3diphenyl-2-thiobarbituric Acid} A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC = 9.5 mM for His-Omi ). Shows very 50 34-458 little activity against various other serine proteases tested (IC ≥ 200 mM). Reported to 50 block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts. Pifithrin-a 506132 [2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr] A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Pifithrin-a, Cyclic- 506134 {2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr; QB102} A cell-permeable and very stable analog of Pifithrin-a (Cat. No. 506 32) with similar biological functions, but with reduced cytotoxicity. Reversibly blocks p53-mediated apoptosis. 0 mg $96 0 mg $ 00 5 mg $84 5 mg $84 5 mg $84 25 mg $237 mg $252 0 mg $98 5 mg 0 mg $65 $ 2 0 mg $ 27 Technical Support Phone 800 628 8470 E-mail calbiochem@emdbiosciences.com 67
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Inhibitor SourceBook Second Editio
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Calbiochem • Inhibitor SourceBook
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Akt (Protein Kinase B) Inhibitors,
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Calmodulin-Dependent Protein Kinase
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Casein Kinase (CK) Inhibitors Casei
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Checkpoint Kinase Inhibitors Eukary
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Cyclin-Dependent Kinase (Cdk) Inhib
Page 17 and 18: Cyclin-Dependent Kinase (Cdk) Inhib
Page 19 and 20: Cyclin-Dependent Kinase (Cdk) Inhib
Page 21 and 22: Glycogen Synthase Kinase-3 (GSK-3)
Page 23 and 24: Glycogen Synthase Kinase Inhibitors
Page 25 and 26: c-Jun N-Terminal Kinase (JNK/SAP Ki
Page 27 and 28: Mitogen-Activated Protein (MAP) Kin
Page 29 and 30: MAP Kinase Inhibitors, continued Ca
Page 31 and 32: Myosin Light Chain Kinase (MLCK) In
Page 33 and 34: Phosphatidylinositol 3-Kinase (PI 3
Page 35 and 36: Calbiochem • Inhibitor SourceBook
Page 37 and 38: Protein Kinase A (PKA; cAMP-Depende
Page 39 and 40: Isozyme Specificities of Selected P
Page 41 and 42: Protein Kinase C (PKC) Inhibitors,
Page 47 and 48: Protein Tyrosine Kinase (PTK) Inhib
Page 57 and 58: Raf Kinase Inhibitors Raf kinases a
Page 59 and 60: Rho Kinase (ROCK) Inhibitors, conti
Page 61 and 62: Protein Phosphatase Inhibitors Calb
Page 63 and 64: Protein Phosphatase Inhibitors, con
Page 65 and 66: Apoptosis Caspase Inhibitors Activa
Page 67: Caspase Inhibitors, continued Produ
Page 73 and 74: DNA Methyltransferase Inhibitors DN
Page 75 and 76: Histone Acetylase and Deacetylase I
Page 77 and 78: Related Products Histone Deacetylas
Page 79 and 80: Nuclear Import/Export Inhibitors, c
Page 83 and 84: Telomerase Inhibitors, continued Ca
Page 85 and 86: Topoisomerase Related Inhibitors, c
Page 87 and 88: Lipid Signaling Acetyl-CoA Carboxyl
Page 89 and 90: Cyclooxygenase (COX) Inhibitors, co
Page 91 and 92: HMG-CoA (3-Hydroxy-3-Methylglutaryl
Page 93 and 94: Lipoxygenase (LOX) Inhibitors Lipox
Page 95 and 96: Phospholipase Inhibitors Several si
Page 97 and 98: Sphingomyelinase Inhibitors Ceramid
Page 99 and 100: Amyloidogenesis Inhibitors Calbioch
Page 101 and 102: Secretase Inhibitors Deposition of
Page 103 and 104: Secretase Inhibitors Calbiochem •
Page 107 and 108: Glutathione S-Transferase (GST) Inh
Page 109 and 110: Guanylate Cyclase Inhibitors, conti
Page 111 and 112: Characteristics of various forms of
Page 113 and 114: Nitric Oxide Synthase (NOS) Inhibit
Page 115 and 116: Proteases Anthrax Lethal Factor (LF
Page 117 and 118: the ratio of active (76 kDa) to ina
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Collagenase Inhibitors (Also see Ma
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Matrix Metalloproteinase (MMP) Inhi
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Matrix Metalloproteinase Inhibitors
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Tissue Inhibitors of Matrix Metallo
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Protease Inhibitors The proper func
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Protease Inhibitors, continued Calb
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Protease Inhibitors, continued Calb
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Protease Inhibitors, continued Sele
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Protease Inhibitor Cocktails, conti
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N Animal-Free Protease Inhibitor Co
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Proteasome and Ubiquitination Pathw
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Transmembrane receptors of various
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Angiotensin-Converting Enzyme (ACE)
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ATPase Inhibitors, continued Calbio
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Inhibitors of Glycoprotein Processi
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Heat Shock Protein Inhibitors Heat
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Inhibitors of Mitochondrial Functio
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NF-kB Activation Inhibitors NF-kB,
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NF-kB Activation Inhibitors, contin
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Phosphodiesterase (PDE) Inhibitors
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Plasminogen Activator Inhibitors Ti
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Protein Synthesis Inhibitors, conti
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Sonic Hedgehog Signaling Inhibitors
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Why can’t I make serial dilutions
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Calpastatin, Human, Recombinant, Do
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InSolution Microcystin-LR, Microcys
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RNA Polymerase III Inhibitor ......
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324875 ............................
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Trademarks CALBIOCHEM®
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Your #1 Resource for Inhibitors! We
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