Inhibitor SourceBook™ Second Edition

Apoptosis
Caspase Inhibitors, continued
Caspase Inhibitor Set I
A set of 3 separate vials. Each set contains mg each of Caspase-3
Inhibitor II, Z-DEVD-FMK (Cat. No. 264 55); Caspase- Inhibitor I,
Ac-YVAD-CHO (Cat. No. 4000 0); and Caspase Inhibitor I, Z-VAD-FMK
(Cat. No. 6276 0).
Cat. No. 235429 1 set $398
Caspase Inhibitor Set II
A set of 8 separate vials of cell-permeable, irreversible caspase
inhibitors. Each set contains 250 µg each of Caspase- Inhibitor VI,
Z-YVAD-FMK (Cat. No. 2 8746); Caspase-2 Inhibitor I, Z-VDVAD-
FMK (Cat. No. 2 8744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat.
No. 264 55); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 2 8753);
Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 2 8757); Caspase-8
Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9 Inhibitor I,
Z-LEHD-FMK (Cat. No. 2 876 ); and Caspase Inhibitor III, Boc-D-FMK
(Cat. No. 2 8745).
Cat. No. 218772 1 set $603
Granzyme Inhibitors
Product Cat. No. Comments Size Price
Caspase-8 Inhibitor I,
Cell-Permeable
218773 (granzyme B Inhibitor II, Cell-permeable; IETD-CHO, Cell-permeable)
A potent, cell-permeable and reversible inhibitor of caspase-8
(FLICE, MACH, Mch5) and granzyme B.
Caspase-8 Inhibitor II 218759 [granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK]
A potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
InSolution Caspase-8
Inhibitor II
218840 [granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK]
A 5 mM (250 mg/76 ml) solution of caspase-8 Inhibitor II (Cat. No. 2 8759)
in anhydrous DMSO.
mg $ 70
66 Orders Phone 800 854 34 7
Calbiochem • Inhibitor SourceBook
Fax 800 776 0999
Web www.emdbiosciences.com/calbiochem
250 mg
mg
$88
$263
250 mg $88
CrmA, Recombinant PF122 An inhibitor of caspase- and granzyme B. 00 mg $5 0
Granzyme B Inhibitor I 368050 (Z-AAD-CMK)
A weak inhibitor of human and murine granzyme B. Also inhibits the apoptosis related
DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease
homologous to granzyme B (ID 50 = 300 nM).
Granzyme B Inhibitor II 368055 (Ac-IETD-CHO; Caspase-8 Inhibitor I)
A potent, reversible inhibitor of granzyme B and caspase-8.
Granzyme B Inhibitor IV 368056 (Ac-IEPD-CHO; Caspase-8 inhibitor III)
A reversible inhibitor of granzyme B that also inhibits caspase-8.
More online... www.calbiochem.com/inhibitors/granzyme
Caspase Inhibitor Set III
A set of 8 separate vials. Each set contains a ready-to-use DMSO
solution of cell-permeable, irreversible inhibitors of various members of
the caspase-family proteases. Contains 25 µl (2 mM) each of Caspase-
Inhibitor VI, Z-YVAD-FMK (Cat. No. 2 8746); Caspase-2 Inhibitor I,
Z-VDVAD-FMK (Cat. No. 2 8744); Caspase-3 Inhibitor II, Z-DEVD-
FMK (Cat. No. 264 55); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat.
No. 2 8753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 2 8757);
Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9
Inhibitor I, Z-LEHD-FMK (Cat. No. 2 876 ); and Caspase Inhibitor I,
Z-VAD-FMK (Cat. No. 6276 0).
Cat. No. 218806 1 set $582
Caspase Inhibitor Set IV
A set of 6 separate vials. Each set contains a ready-to-use solution of cellpermeable
caspase inhibitors and an apoptosis inducer. Contains 25 µl of a
0 mM solution in DMSO of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No.
264 55); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 2 8759); Caspase-9
Inhibitor I, Z-LEHD-FMK (Cat. No 2 876 ); general caspase inhibitor,
Z-VAD-FMK (Cat. No. 6276 0); the negative control Z-FA-FMK (Cat.
No. 342000), and an aqueous solution ( 00 µl, 0.5 µM) of an apoptosis
inducer, Doxorubicin, Hydrochloride (Cat. No. 324380).
Cat. No. 218825 1 set $325
mg $69
mg $60
mg $84