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Statistical Methods in Medical Research 4ed

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454 Further regression models<br />

Spells commenc<strong>in</strong>g per week<br />

40<br />

30<br />

20<br />

10<br />

New Year<br />

0 0 10<br />

August Bank Holiday Christmas week<br />

20 30 40 50<br />

Week no.<br />

Fig. 12.11 The estimated seasonal trend <strong>in</strong> weekly spells of sickness absence (1960±64) (reproduced<br />

from Pocock, 1974, with permission from the author and publishers).<br />

is a s<strong>in</strong>gle s<strong>in</strong>usoidal curve with a period of 1 year. A comparison of the two curves shows<br />

that the seasonal trend is nearly s<strong>in</strong>usoidal, but that there are clear departures from the<br />

simple curve, particularly at annual holiday periods.<br />

Spectral analysis<br />

Here the time series is effectively decomposed <strong>in</strong>to an <strong>in</strong>f<strong>in</strong>ite number of periodic<br />

components, each of <strong>in</strong>f<strong>in</strong>itesimal amplitude, so the purpose of the analysis is to<br />

estimate the contributions of components <strong>in</strong> certa<strong>in</strong> ranges of frequency. A<br />

spectral analysis may show that contributions to the fluctuations <strong>in</strong> the time<br />

series come from a cont<strong>in</strong>uous range of frequencies, and the pattern of spectral<br />

densities may suggest a particular time-doma<strong>in</strong> representation. Or the spectral<br />

analysis may suggest one or two dom<strong>in</strong>ant frequencies, lead<strong>in</strong>g to a subsequent<br />

harmonic analysis. A further possibility is that the spectrum may be a mixture of<br />

discrete and cont<strong>in</strong>uous components, as, for example, <strong>in</strong> a time series <strong>in</strong> which a<br />

harmonic term is comb<strong>in</strong>ed with an autoregressive error term.<br />

Various features of a spectral decomposition may provide useful summary<br />

statistics for a time series. Gev<strong>in</strong>s (1980), for <strong>in</strong>stance, reviews a considerable<br />

body of work <strong>in</strong> which spectral analyses of series of human bra<strong>in</strong> electrical<br />

potentials have been used to discrim<strong>in</strong>ate between different cl<strong>in</strong>ical states or as<br />

a basis for various forms of pattern recognition and cluster analysis.

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