Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
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124<br />
Appendix 4<br />
TABLE 66 contd Summary of adult clinical outcomes studies<br />
Study Investigations and subjects Outcome Results Conclusions and<br />
measures grade of evidence<br />
Korttila et al., (1) Propofol induction, propofol repeat (a) Respond (a): (1) 13.9, (2) 18.0 min; Grade I<br />
1992, 87 USA 3 min later (n = 6) to command p < 0.05<br />
RCT (2) Thiopentone induction, thiopentone (b) Body sway (b–h): Data given as graphs Method of randomisation<br />
repeat 3 min later (n = 6) only.Thiopentone more than not reported<br />
(c) Choice propofol at 1 and 3 h;<br />
N 2O: not given reaction time p < 0.05. Returned to Double-blind<br />
control by 7 h<br />
Premedication: none (d) Co- Crossover<br />
ordination/<br />
Gender: men volunteers computer Volunteers<br />
(e) DSST<br />
(f) Maddox<br />
Wing<br />
(g) Computer<br />
steering wheel<br />
(h) CFFT<br />
Korttila et al., (1) Propofol TIVA (n = 21) (a) Obey (a): (1) 3.7, (2) 6.2 min; Grade I<br />
1990, 88 USA command p < 0.05<br />
(2) Thiopentone, isoflurane (n = 20)<br />
RCT (b) Orientation (b): (1) 5.7, (2) 10.0 min; Method of randomisation<br />
N 2O: given p < 0.05 not reported<br />
(c) Sit unaided<br />
Premedication: none (c): (1) 58, (2) 77 min; NS<br />
(d) Discharge Blind<br />
Procedures: gynaecology, general (d): (1) 136, (2) 204 min;<br />
(e) Perceptive p < 0.05<br />
Gender: 83% women accuracy<br />
(e): (1) 102, (2) 136 min;<br />
(f) Finger p < 0.05<br />
tapping<br />
(f): (1) 104, (2) 124; NS<br />
(g) Maddox<br />
Wing (g): (1) 112, (2) 140; NS<br />
(h) PONV (h): (1) 7/20 15/20; p < 0.05<br />
Larsen et al., (1) Propofol TIVA (n = 15: 12 men) (a) Choice (a): No differences Grade I<br />
1992, 99 Sweden reaction time<br />
(2) Propofol/isoflurane (n = 15: 9 men) (b): p < 0.05 Method of randomisation<br />
RCT (b) Perceptive not reported<br />
N 2O: not given accuracy test<br />
Premedication: none<br />
Procedures: knee arthroscopy<br />
Age: 18–45 years<br />
continued