Aanesthetic Agents for Day Surgery - NIHR Health Technology ...

134
Appendix 4
TABLE 66 contd Summary of adult clinical outcomes studies
Study Investigations and subjects Outcome Results Conclusions and
measures grade of evidence
Short et al.,
1985,
(1) Methohexitone, alfentanil, N2O, O2 (a) Time to Group 2 abandoned after Grade I
122 UK (n = 20: 14 women, 6 men) open eyes 11 patients due to poor
conditions during induction Method of randomisation
RCT (2) Methohexitone, isoflurane, O2 (n = 20: 8 women, 3 men)
(b) Time to
recall date (a): (1) 9.2, (3) 9.1 min;
not reported
of birth p < 0.01 Not blind
(3) Methohexitone, isoflurane, N2O, O2 (n = 20: 10 women, 10 men) (c) Time to (b): (1) 9.9, (3) 9.7 min; The majority of group 2
recall name p < 0.01 patients were not able to
N2O: given in groups 1 and 3 complete the trial
(d) Post-box (c): (1) 9.5, (3) 9.6 min;
Premedication: none test p < 0.01
Procedures: D&C, cystourethroscopy (e) P-deletion (d): (1) 34.3, (2) 44.3, (3) 40.3;
Age: > 18 years; mean (1) 45, (2) 46,
test p < 0.01 group 2
(3) 43 years (e): (1) 4; (2) 2; (3) 2; NS
Sivalingam ASA grade I or II LMA insertion Satisfactory or excellent: (1) Grade I
et al., 1999, 123
(quality for 64%, (2) 64%, (3) 100%, (4)
Singapore (1) Propofol 2.5 mg/kg + 10 mg induction only): 88%; p < 0.001 Method of randomisation
increments i.v. (n = 25) excellent, not reported
RCT satisfactory
(2) Sevoflurane 8% + 60% N 2O vital or poor Open
capacity breath (n = 25)
(3) Sevoflurane as (2) + alfentanil
5 µg/kg (n = 25)
(4) Propofol as (1) + alfentanil 5 µg/kg (n = 25)
N 2O: given in groups 2 and 3
Premedication: none
Procedures: mixed
Gender: 55% men
Sloan et al.,
1996,
Age: 16–65 years
(1) Sevoflurane/sevoflurane + N2O (n = 25) (a) Open eyes (a): (1) 8.1, (2) 10.6 min Grade I
124 USA
(2) Isoflurane/isoflurane + N2O (n = 25) (b) Obey (b): (1) 8.0, (2) 9.9 min Method of randomisation
RCT command not reported
N2O: given (c): (1) 9.9, (2) 12.6 min
(c) Orientation Not blind
Premedication: none (d): (1) 120, (2) 133 min
(d) Discharge
Procedures: not reported (e): Data not given
(e) DSST
Age: 18–76 years No difference between groups
Smith and
Thwaites,
(1) Sevoflurane./sevoflurane (n = 30) (a) Open eyes (a): 7.1 min; p = 0.027 Grade I
1999, 125
(2) Propofol TCI (n = 31) (b) Date of (b): 8.1 min; NS Method of randomisation:
England birth computer-generated
N2O: not given (c): 100 min; p = 0.024 random numbers
RCT (c) Sit up
Premedication: none
(d) Walk
(d): 175 min; NS Blind
Procedures: mixed
(e) Street fit
(e): 193 min; p = 0.005
Gender: 66% women
Age: 18–73 years
(f) PONV
(f): (1) 9%; (2) 1%; p = 0.006
continued