Aanesthetic Agents for Day Surgery - NIHR Health Technology ...

The adverse events observed in the adult study
are summarised in Tables 110 to 114.
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Appendix 27
Health Technology Assessment 2002; Vol. 6: No. 30
Adverse events in the adult study
TABLE 110 Incidence of adverse events, other than PONV, by randomisation group in the adult study
Total No. No. of patients
of patients
0 adverse 1 adverse 2 adverse 3 adverse 4 adverse
event event events events events
Adult study 1063 776 235 43 8 1
Propofol/propofol 265 186 62 16 1 0
Propofol/isoflurane 267 202 50 12 3 0
Propofol/sevoflurane 280 222 51 5 1 1
Sevoflurane/sevoflurane 251 166 72 10 3 0
TABLE 111 Frequency of adverse events, other than PONV, on
induction in the adult study
Adverse event No. of patients
None 858 (80.7%)
Pain on induction 59 (5.6%)
Excitatory movement during induction 49 (4.6%)
Breath-holding 42 (4.0%)
Coughing 35 (3.3%)
Hiccough 29 (2.7%)
Laryngospasm 14 (1.3%)
Excessive salivation 6 (0.6%)
Unable to intubate or laryngeal
mask used
5 (0.5%)
Difficult intubation 4 (0.4%)
Very dry mouth 2 (0.2%)
Technical problem 2 (0.2%)
Drug allergy 1 (0.1%)
Saturations dropped 1 (0.1%)
Arrhythmias 1 (0.1%)
Tachycardia 1 (0.1%)
TABLE 112 Frequency of adverse events other than PONV in
the operating theatre in the adult study
Adverse event No. of patients
None 981 (92.3%)
Patient moved a lot during surgery *
34 (3.2%)
Surgery more extensive or prolonged 19 (1.8%)
Saturations dropped 10 (0.9%)
Arrhythmias 3 (0.3%)
Tachycardia 2 (0.2%)
Laryngospasm 2 (0.2%)
Awareness 2 (0.2%)
Minor bleeding 1 (0.1%)
Shivering 1 (0.1%)
Aspiration 1 (0.1%)
Technical problem 1 (0.1%)
Unable to intubate or laryngeal
mask used
1 (0.1%)
Coughing 1 (0.1%)
Hyperventilation 1 (0.1%)
Hiccough 1 (0.1%)
Excessive salivation 1 (0.1%)
Vomiting after removal of laryngeal
mask
1 (0.1%)
* Propofol/propofol, 15; propofol/isoflurane, 8;
propofol/sevoflurane, 6; sevoflurane/sevoflurane, 5
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