Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
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62<br />
Results of the adult economic evaluation<br />
TABLE 39 RRRs <strong>for</strong> PONV in the adult study<br />
Variable Assigned distribution *<br />
Propofol/ Propofol/ Propofol/ Sevoflurane/<br />
propofol isoflurane sevoflurane sevoflurane<br />
Probability of PONV with no 0.14 0.18 0.17 0.30<br />
ondansetron (path 1) Triangular: Triangular: Triangular: Triangular:<br />
0.10–0.18 0.13–0.23 0.13–0.21 0.24–0.23<br />
Probability of PONV with ondansetron 0.05 0.07 0.07 0.11<br />
(path 3) Triangular: Triangular: Triangular: Triangular:<br />
0.03–0.07 0.04–0.10 0.04–0.09 0.07–0.16<br />
Mean cost of PONV with no 21.55 †<br />
9.60 16.34 18.21<br />
ondansetron (path 1) Beta subjective: Beta subjective: Beta subjective: Beta subjective:<br />
10.8, 10.9, 3.8, 3.9, 7.4, 7.4, 7.1, 7.2,<br />
21.55, 51.16 9.60, 17.61 16.34, 33.78 18.21, 45.84<br />
Mean cost of no PONV with no 21.07 6.91 13.24 14.10<br />
ondansetron (path 2) Beta subjective: Beta subjective: Beta subjective: Beta subjective:<br />
2.3, 10.9, 1.2, 1.3, 3.7, 3.8, 4.7, 4.8,<br />
21.07, 147.69 6.91, 38.76 13.24, 135.91 14.10, 44.47<br />
Mean cost of PONV with 25.44 13.52 20.27 22.17<br />
ondansetron (path 3) Beta subjective: Beta subjective: Beta subjective: Beta subjective:<br />
10.8, 10.9, 3.8, 3.9, 7.4, 7.4, 7.1, 7.2,<br />
21.55, 51.16 9.60, 17.61 16.34, 33.78 18.21,45.84<br />
Mean cost of no PONV with 24.96 10.83 17.17 18.06<br />
ondansetron (path 4) Beta subjective: Beta subjective: Beta subjective: Beta subjective:<br />
2.3, 10.9, 1.2, 1.3, 3.7, 3.8, 4.7, 4.8,<br />
21.07, 147.69 6.91, 38.76 13.24, 135.91 14.10, 44.47<br />
* Triangular distribution parameters required <strong>for</strong> simulation: minimum, maximum. Beta-subjective distribution parameters required <strong>for</strong><br />
simulation: minimum, mode, distribution-defined mean, maximum<br />
† The mean returned by the simulation on the beta-subjective distribution, utilising the given distribution parameters<br />
Patient admitted <strong>for</strong> day<br />
surgery and anaesthesised<br />
with propofol/propofol<br />
No anti-emetic prophylaxis<br />
Anti-emetic prophylaxis<br />
PONV<br />
0.14<br />
No PONV<br />
PONV<br />
0.86<br />
0.05<br />
No PONV<br />
FIGURE 12 The decision tree <strong>for</strong> simulating the effect of prophylactic ondansetron with the propofol/propofol regimen in the<br />
adult study<br />
0.95<br />
21.55<br />
21.07<br />
25.44<br />
24.96