Aanesthetic Agents for Day Surgery - NIHR Health Technology ...
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TABLE 66 contd Summary of adult clinical outcomes studies<br />
© Queen’s Printer and Controller of HMSO 2002. All rights reserved.<br />
<strong>Health</strong> <strong>Technology</strong> Assessment 2002; Vol. 6: No. 30<br />
Study Investigations and subjects Outcome Results Conclusions and<br />
measures grade of evidence<br />
O’Hara et al., (1) Thiopentone, sevoflurane, N 2O (a) Open eyes (a): (1) 9.7, (2) 11.9 min; NS Grade I<br />
1996, 104 USA (n = 25)<br />
(b) Orientation (b): (1) 13.6, (2) 17 min; Method of randomisation<br />
RCT (2) Thiopentone, isoflurane, N 2O p = 0.02 not reported<br />
(n = 22) (c) Discharge<br />
(c): (1) 244, (2) 282 min; NS Not blind<br />
N 2O: given (d) PONV (%)<br />
(d): (1) 64%, (2) 54%; NS<br />
Premedication: none (e) DSST<br />
(e): No differences<br />
Procedures:“generally gynaecology” (graph data only)<br />
Gender: women<br />
Mean ± SD age: 34.3 ± 1.2 years<br />
Oikkonen, (1) Alfentanil, propofol, suxamethonium, (a) Open eyes/ (a–c): Data given on the Grade I<br />
1994, 105 Finland alfentanil, propofol TIVA (n = 15) waken number of patients fulfilling<br />
the criteria at a number of Method of randomisation<br />
RCT (2) Alfentanil, propofol, suxamethonium, (b) Name, specified times. Group 1 not reported<br />
alfentanil, isoflurane (n = 15) date of birth better than group 2; p < 0.01<br />
in all cases Not blind<br />
N 2O: not given (c) Obey<br />
command (d): NS<br />
Premedication: diazepam, glyco.,<br />
alcuronium (d) P-deletion<br />
test<br />
Procedures: gynaecological laparoscopy<br />
Mean ± SD age: 38 ± 6 years<br />
Ong et al., (1) Fentanyl, propofol, propofol TIVA, (a) Open eyes (a): (1) 307, (2) 440 s; NS Grade I<br />
2000, 106<br />
Singapore<br />
no N2O (n = 40)<br />
(b) Orientation (b): (1) 346, (2) 427 s; NS Method of randomisation<br />
(2) Sevoflurane + N2O (n = 40) not reported<br />
RCT (c) PONV (c): (1) 0%, (2) 2.5%; NS<br />
N2O: given in group 2 Not blind<br />
Premedication: none<br />
Procedures: minor gynaecological<br />
Patil et al., 1999, 107 (1) Sevoflurane (n = 39: 4 women, (a) Time to (a): (1) 42.7, (2) 44.2 min; NS Grade I<br />
Mumbai 35 men) induction<br />
(b): (1) 0%, (2) 1%; NS Method of randomisation<br />
RCT (2) Thiopentone (n = 39: 7 women, (b) PONV not reported<br />
32 men) (c): (1) 9.7, (2) 11.2 min;<br />
(c) Recovery p = 0028 Not blind<br />
N 2O: given in group A<br />
(d) Tandem (d): (1) 22, (2) 12; p < 0.05<br />
Premedication: none walking test<br />
(able to walk Incidence of arrhythmias<br />
Procedures: laryngoscopy at 30 min) higher in group 2; p < 0.05<br />
Age: > 18 years; mean ± SD<br />
56 ± 57 years<br />
continued<br />
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