Aanesthetic Agents for Day Surgery - NIHR Health Technology ...

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240 Appendix 25 V41.2 anterior attachment of correctional instrument to spine A67.9 release of trapped peripheral nerve B10.1 excision of thyroglossal cyst. Bone W03.5 localised fusion of joints of midfoot and forefoot W28.3 removal of interior fixation from bone NEC W32 other graft of bone X11.2 amputation of phalanx of toe X11 amputation of toe Y42 manipulation of organ, NEC Z89.1 shoulder, NEC. Knee W82.3 endoscopic repair of semilunar cartilage W85.1 endoscopic removal of loose body from knee joint W85.2 endoscopic irrigation of knee joint W85 therapeutic endoscopic operations on knee joint cavity W86.1 endoscopic removal of loose body from joint, NEC W87.1 diagnostic endoscopic examination of knee joint and biopsy lesion W87.9 diagnostic endoscopic examination of knee joint and biopsy lesion W87 diagnostic endoscopic examination of knee joint. Joints W62.9 other primary fusion of other joint W81.5 exploration of joint, NEC W88.9 endoscopic examination of other joint, unspecified W90.1 aspiration of joint W90.3 injection of therapeutic substance into joint W91 other manipulation of joint W92.4 examination of joint under anaesthetic. Breasts B27.9 total excision of breast B28 other excision of breast.
This section displays the association between PONV and other variables, which plausibly might be associated with risk. Tables are displayed to check the evenness of the distributions of these potential confounding variables across the randomisation arms. The total numbers of subjects shown in the tables vary slightly, since some of the variables have missing data. Probability values presented with tables refer, unless otherwise stated, to a simple test for heterogeneity among categories. So-called ‘exact’ tests were employed when appropriate. Probability values are not presented for tables examining the distribution of potential confounding variables among the randomisation categories, as the statistical significance of observed differences is not relevant to the question of confounding. Gender Table 97 shows a marked gender difference in risk of PONV. The marked gender difference is also present, and in the same direction, when one or more episodes and two or more episodes of vomiting are examined (data not displayed). Table 98 confirms that the difference in PONV among anaesthetic regimens is true for both genders, although varying around differing bases. Age Table 99 shows the age breakdown of the adult population in four nearly equally sized groups (quartiles). These quartiles are employed in a © Queen’s Printer and Controller of HMSO 2002. All rights reserved. Appendix 26 Health Technology Assessment 2002; Vol. 6: No. 30 Analysis of confounding factors for PONV in the adult study TABLE 97 Occurrence of any PONV by gender in the adult study number of tabulations that follow. Even though the male and female age distributions differ, these same quartiles are, for simplicity of presentation, used when sex-specific tabulations are presented. This made no material difference to the interpretation of the data and age was used on its natural scale in the subsequent regression analyses. The age ranges of quartiles are: 1. < 32.4 2. 32.4–41.2 3. 41.3–53.4 4. > 53.4. Table 99 shows a marked gradient in PONV by age; the older patients appear to be at less risk. This pattern is maintained when one or more episodes of vomiting is considered. However, Table 100 demonstrates a strong gradient with age among women only, not among men. The pattern (and statistically significant gradient for women) remains when one or more episodes of vomiting is considered. The marked age difference is also present, and in the same pattern, when one or more episodes and two or more episodes of vomiting are examined. Tabulation of one or more episodes of vomiting shows a linear trend for women (p < 0.01). Type of surgery Tables 101 and 102 show that within broad categories of surgical procedure there are differences in risk, the high level in gynaecology is similar to the results of other trials. The data for women No. of patients Men Women Total Total 269 (100%) 792 (100%) 1061 (100%) Nausea or vomiting – no 259 (96.3%) 595 (75.1%) 854 (80.5%) Nausea or vomiting – yes 10 (3.7%) 197 (24.9%) 207 (19.5%) p < 0.001 241
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Which anaesthetic agents are costef
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Which anaesthetic agents are costef
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NHS R&D HTA Programme The NHS R&D H
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Contents Appendix 6 Adult patient-b
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Background The aim of the project w
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• The incidence of PONV was low d
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2 Introduction dizziness or disorie
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4 Introduction a reduced incidence
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6 Introduction willingness to pay f
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8 Literature review included in the
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10 Literature review TABLE 1 Compar
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12 Literature review intermediate a
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18 Literature review Patient-based
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20 Literature review TABLE 5 contd
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22 Literature review No studies fol
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24 Literature review (30%) and meth
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26 Literature review • There are
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28 National survey of anaesthetic p
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36 Economic evaluation methods (inc
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38 Economic evaluation methods The
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40 Economic evaluation methods Tabl
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42 Economic evaluation methods simi
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44 Economic evaluation methods Prob
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Recruitment to the CESA RCT The stu
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Clinical outcome data PONV by anaes
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The findings from the logistic regr
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TABLE 29 The length of stay and pri
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140 120 100 80 60 40 20 0 No. of pa
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250 200 150 100 50 0 No. of patient
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TABLE 37 Deterministic sensitivity
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20 15 10 5 0 -5 Difference in varia
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Patient admitted for day surgery an
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500 400 300 200 100 0 -100 -200 -30
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Recruitment to the CESA RCT The stu
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TABLE 49 The occurrence of any PONV
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60 50 40 30 20 10 0 No. of patients
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a scale effect for scenario A, but
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The mean CVs for avoidance of PONV
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1.80 The new variable cost and tota
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100 90 80 70 60 50 40 30 20 10 0 Su
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The structure and content of this d
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nurses to have an in-depth knowledg
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agent used (see appendix 18). It wa
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Furthermore, anaesthetists operate
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The CESA project was designed to as
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practice, such as the use of midazo
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1. Royal College of Surgeons of Eng
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60. Cheng KI, Chu KS, Fang YR, Su K
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112. Raeder J, Gupta A, Pedersen FM
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162. Viitanen H, Baer G, Annila P.
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220. Rosenberg KM, Bridge P, Brown
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The range of databases interrogated
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24. preferen$.mp. [mp=title, abstra
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110 Appendix 2 TABLE 65 contd Summa
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112 Appendix 3 Quality assessment o
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TABLE 69 Summary of paediatric pati
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TABLE 69 contd Summary of paediatri
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TABLE 70 Characteristics of cost or
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TABLE 71 Quality of cost or economi
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TABLE 71 contd Quality of cost or e
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Abbott J, Abbott P. Psychological a
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Hall JE, Stewart JIM, Harmer M. Sin
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Struys M, Versichelen L, Thas O, He
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182 Appendix 11
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184 Appendix 11
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186 Appendix 11
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188 Appendix 11
Page 205 and 206: The aim of this study was to develo
Page 207 and 208: anaesthetics in day surgery, using
Page 209: © Queen’s Printer and Controller
Page 213 and 214: Background The empirical study quan
Page 215 and 216: Satisfaction with care Nearly all (
Page 217 and 218: TABLE 76 Reason given for preferenc
Page 219 and 220: TABLE 79 Comparisons with previous
Page 221 and 222: TABLE 80 Reason given for preferenc
Page 223 and 224: TABLE 81 Reason given for willingne
Page 225 and 226: Background Variable costs account f
Page 227 and 228: TABLE 85 Unit costs for the purchas
Page 229 and 230: Background The empirical study requ
Page 231 and 232: Ethical approval This was covered b
Page 233 and 234: 20 15 10 5 0 -5 -10 -15 True weight
Page 235: 15 10 5 0 -5 -10 True weight - Dion
Page 238 and 239: 224 Appendix 19 • patients aged o
Page 241 and 242: All staff unit costs were for the y
Page 243: Background Fixed costs account for
Page 246 and 247: 232 Appendix 22 March, Tuesday 15 A
Page 248 and 249: 234 Appendix 23 TABLE 96 Reasons fo
Page 251 and 252: Patients were coded using the OPCS
Page 253: Q03.4 punch biopsy of cervix Q03.5
Page 257 and 258: given in Table 103 confirm the age
Page 259: TABLE 107 Occurrence of PONV by dur
Page 262 and 263: 248 Appendix 27 TABLE 113 Frequency
Page 265 and 266: This section displays the associati
Page 267 and 268: The adverse events observed in the
Page 269 and 270: 262 Health Technology Assessment Pr
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