effect of infection of the filarial parasite brugia malayi - Pondicherry ...

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1.4 Histopathology Although traditionally regarded as lymphatic filarial parasites in their natural hosts, such as man, cats and monkeys, B, malayi and related species show a characteristic tendency to localize within the major organs like lungs, heart and testes of M. natalensis (section 4.1.2). in Meriones unguiculatuc (Ash, 1973b, Ash and Riley, 1974b; ElBihari and Ewert, 1971). Such development has been interpreted as an aborrant mode of development (Ash, 1973a; Vincent et al.. 1976). Vincent el a/. (1976) studied the chronological development of pulmonary pathology associated with B.malayi, B.pahangi and B. patei. Histological studies by Hawking et a1.(1950) had concluded that DEC in some way promotes phagocytosis of the mf. The enzyme studies in B.malayi infected animals in the present study has shown cellular injury and membrane damage, hence histopathological studies on various organs after infection and after DEC treatment was carried out
Page 1 and 2: EFFECT OF INFECTION OF THE FILARIAL
Page 4 and 5: I wish to express my deep sense of
Page 6: 1. INTRODUCTlON 2. REVIEW OF LlTERA
Page 9 and 10: As stated earlier, the host immune
Page 11: 13 Testicular changes Testosterone
Page 15 and 16: Fig.1 LIFE CYCLE OF LYMPHATIC FILAR
Page 17 and 18: development of B. malayi, B.pahangi
Page 19 and 20: Emerson (1975) showed that DEC trea
Page 21 and 22: MATERIALS , ., $< AND @aws \\\\ b~
Page 24 and 25: 4. EXPERIMENTS CHAPTER 4.1 CHANGES
Page 26 and 27: dichromate/acetic acid mixture. The
Page 28 and 29: paoxide and 0.2 ml of reduced gluta
Page 30 and 31: Reagent6 1. DTNB : 0.6 mM in 0.2 M
Page 32 and 33: 4.1.1.10 Lipid peroxidation Lipid p
Page 34 and 35: Fig 2:B.malayi distribution in Lung
Page 36 and 37: LIST OF ABBREVIATIONS USED IN THE G
Page 38 and 39: :iq Fig.6: Effect of B.malayi on Ca
Page 40 and 41: Whereas in the infected animals, or
Page 42 and 43: - a g 25- to- Fig.15: Effect of B.m
Page 44 and 45: 4.1.2.1.7 Reduced glutathione The G
Page 46 and 47: 5 12g 10- = Fig.24: Effect of B.mal
Page 48 and 49: 137 12- 11 - a- ? 5. s 6," -9 6. 5
Page 50 and 51: Fig.33:Effect of 6.malayi on SOD in
Page 52 and 53: Fig.37: Effect of B.malayi on GST i
Page 54 and 55: The GR and G6PDH activities in live
Page 56 and 57: Fig.43: Effect of B-rnalayi on GGPD
Page 58 and 59: Fig.47: Effect of B.malayi on SH in
Page 60 and 61: Fig.51: Effect of B.malayi on LPO i
Page 62 and 63:
FIG. 53 FORMATION AND DETOXIFICATIO
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FIG. 54 THE SEQUENCE OF EVENTS IN F
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0 Fig.55:Relationship between chang
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Fig.6O:Relationship between change
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The LPO altered during infection of
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3 a- 7. 6- Fig.65:Relationship betw
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the period by which, the parasite a
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(Figs. 75-79) and it was significan
Page 78 and 79:
Fig.73:Relationship between change
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Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
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0 4 0 - lo' 6- 8 WJ 4- 0 2 -
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12 6Y 0 4 2 0 Fig. 100:Relationship
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CHAPTER 4.2 CHANGES IN THE ACTMTY O
Page 94 and 95:
To the reaction mixture containing
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Reagents 1. L-y-glutamyl pnitmkilid
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The method involves an accurate dil
Page 100 and 101:
Fig. 105: Effect of 6.malayi on N~+
Page 102 and 103:
Fig.! 08:Effect of B.malayi on ~ a'
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801 70 - 0, - 3 60m > 50- 40- Fig.
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thereby increasing intracellular ca
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CHAPTER 4.3 CHANGES IN THE TESTES O
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4. MTT : 5 mg in 1 ml water 5. Phen
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Plate 1: Electrophoresis of LDH -X
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its absence in B. malayi infected a
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Plate2 Section of Lung of infected
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Plate$: Section of Lung of infected
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4.4.2.1.2 Heart The heart of the co
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Platc 14 Plate 15 Platc I6 Plate 17
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Plate a Section of Brain of infecte
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I'iatc 26 Plate 2:
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Plate 31: Section of Testes of infe
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pahangi and no lesions in the kidne
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5. SUMMARY The effect of B.mala)ti
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ain, heart and lungs. However, in t
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6. CONCLUSION B. malayi infection o
Page 142 and 143:
Babior, B.M., Kipnes, R.S. and Curn
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Condell, R.A. and Tappel, A.L. (198
Page 146 and 147:
Fairfield, AS., Abosch, A., Ram, A.
Page 148 and 149:
Hams, H, and Hopkinson, D.A. (1978)
Page 150 and 151:
Konigk, E. And Mirtsch, S. (1977).
Page 152 and 153:
Marshall, G.R., Wickings, E.J. and
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Panicker, N.V. and Zyer, G.Y.N. (19
Page 156 and 157:
Skinner, M.K. (1987). Cell-cell int
Page 158 and 159:
Vincent, A.L., Frammes, S.P. and As
Page 160:
APPENDIX Haematological values of M
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