effect of infection of the filarial parasite brugia malayi - Pondicherry ...

4.1.2.1.7 Reduced glutathione
The GSH levels in the control animals showed an increasing trend throughout the
study period (Figs. 21-23). Whereas, in the infected animals, the liver, testes and heat
showed significant w0.05) decrease in the activity from day 30 to day 120 and in the brain
from day 0 to day 120. However, the lungs showed increasing trend from 30 days to 120
days as in control, but the activity was lower than that of the control.
4.1.2.1.8 Total thiol group
The total hi01 status in the organs of the control animals showed a steady increase
from 0 to 120 days (Figs. 24-26), whereas, the liver, testes and brain of the infected animals
showed a significant decrease w.05). The heart also showed similar trend, but from 30th
to 120thday only. In the lungs, however, the thiol level declined from 0 to 30 days and then
increased significantly wO.05) as in the control. But the values were lower than the control.
4.1.2.1.9 Ascorbic acid
Ascorbic acid content in the organs of mfected and contml animals are pmted in
Figs. 27-29. In the organs of the control animals it increased from 0 to 120 days whereas, in
the infected animals, significant decrease w0.05) was observed throughout the study pencd
in testes and heart and it decreased in liver and brain from 30th day to 120th day. However,
in the lungs significant increase (~~0.05) was noticed from 30th day to 120th day and the
values were lower than that observed in control.
4.1.23 Lipid peroxidation
The level of lipid peroxidation was measured in terms of malondialdehyde
released and is presented in Figs. 30-32. The LPO was significantly higher w0.05) in
liver, testes, brain and heart of both control and B.m~layc infected animals. On the
contrary, in the lungs of infected animals there was significant wO.05) reduction in LPO
levels as compartd to the controls.