effect of infection of the filarial parasite brugia malayi - Pondicherry ...

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Fig 2:B.malayi distribution in Lungs testes & heart of M-natalensis Testes (37.07) Lungs (44.38) Figures in parenthesis are %age of adult worms recovered
4.1.2.1 Changes in antioxidant enzymes and antioxidants in control and B.m&yi infected animals 4.1.2.1.1 Superoxide dismutase The changes in the activity of SOD in the organs of infected and control animals are presented in Figs. 3-5. In control animals, all the organs (viz., the liver, testes, brain, heart and lungs) showed a continuous increase in the activity of this enzyme from 0 to 120 days. Contrary to this, in the testes, heart and brain of the infected animals, the activity of this enzyme showed an increasing trend upto 30 days and thereafter the enzyme activity declined s~gn~ficantly w0.05), while in the liver, the activity increased sigmficantly upto 60 days and thereafkr declined. And in the lungs the enzyme activity showed increasing trend throughout and the activity was higher than that of control . 4.1.2.1.2 Catalase The changes in the catalase activity are shown in Figs. 6-8. All the organs of the control animals showed increase in catalase activity from 0 to 120 days. Compared to this, the tesw, heart and brain of the infected animals showed decline in the enzyme activity from 30th day while liver showed significant m.05) decline from 60th day. However, the lungs showed a steady increase in catalase activity from 30 days (significant at F0.05) and the increase was much higher than that observed in control. 4.1.2.13 Clutathione-s-transferase The activity of GST in various organs of the infected and control animals are shown in F~gs. 9-1 1. The GST activity was found to increase in control animals from day 0 to day 120.
Page 1 and 2: EFFECT OF INFECTION OF THE FILARIAL
Page 4 and 5: I wish to express my deep sense of
Page 6: 1. INTRODUCTlON 2. REVIEW OF LlTERA
Page 9 and 10: As stated earlier, the host immune
Page 11 and 12: 13 Testicular changes Testosterone
Page 14 and 15: 2. REVIEW OF LITERATURE Filariasis
Page 16 and 17: 2.2 Clinical signs Inflammalation o
Page 18 and 19: the tegument by the release of thei
Page 20 and 21: the compound kills the filarial wor
Page 22: 3. MATERIALS AND METHODS COLONY MAI
Page 25 and 26: Ragenb 1. Tris-HCI buffer . : 0.1 M
Page 27 and 28: 3. Reduced glutathione : 30 mM To I
Page 29 and 30: 4.1.1.6 Glucose-6-phosphate dehydro
Page 31 and 32: absorbance of the clear supernatant
Page 33: -eats I. Lowry's reagent :Solution
Page 37 and 38: Fig.3: Effect of B.malayi on SOD in
Page 39 and 40: Fig.9: Effect of B.rnalayi on GST i
Page 41 and 42: Fig.12: Effect of 6.rnalayi on GPx
Page 43 and 44: Fig. 18: Effect of B.malayi on G6PD
Page 45 and 46: 12- 3 m- 15- lor, Fig.21: Effect of
Page 47 and 48: Fig.27: Effect of B.malayi on Ascor
Page 49 and 50: 4.1.2.3 Change in the antioxidant e
Page 51 and 52: Fig.35: Effect of B.malayi on CAT i
Page 53 and 54: m 20 0) - 15 9 g 10 il! 5 0 Fig.39:
Page 55 and 56: 30 25 8 - a 20 2 15 C I 10 I 5 0 35
Page 57 and 58: Fig.45: Effect of B.maiayi on GSH i
Page 59 and 60: Fig.49: Effect of B.malayi on Vit-C
Page 61 and 62: 4.1.3 DISCUSSION 4.1 3.1.1 Toxic ox
Page 63 and 64: 1973). The two major systems of LPO
Page 65 and 66: 1981), and their increase in human
Page 67 and 68: 1 0 Fig.58:Relationship between cha
Page 69 and 70: 1 - 0- ' 1 5 - 6 - 7 - Fig.63:Relat
Page 71 and 72: Catalase had been reported to be re
Page 73 and 74: - Fig.68:Relationship between chang
Page 75 and 76: esults in its reduced activity (Con
Page 77 and 78: g 20- :I-. F1g.70:Relationship betw
Page 79 and 80: 12, - I 0 U) Q 4 2 0 - + - Fig.75:R
Page 81 and 82: $ Fig.80:Relationship between chang
Page 83 and 84: Fig.85:Relationship between change
Page 85 and 86:
V) (3 :; - Fig.9O:Relationship betw
Page 87 and 88:
A reduction in the total thiol cont
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2 5- Fig.98:Relationship between ch
Page 91 and 92:
Fig. 103:Relationship between chang
Page 93 and 94:
4.2.1.1 N ay ATPase Reagents Nay AT
Page 95 and 96:
Reagents 1. Acetylcholine bromide :
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To 1.5 ml of carbonate buffer, 1.5
Page 99 and 100:
4.2.1.10 Differential leucocyte cou
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increase in the control animals (Fi
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- Fig.110: Effect of 6. malayi on H
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efflux and thereby alter the membra
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with i n d lymphocytes and decrease
Page 109 and 110:
Tubes were labeled for calibrators,
Page 111 and 112:
Fig.114: Effect of B, malayi on GTP
Page 113 and 114:
433 DISCUSSION Testosterone is a se
Page 115 and 116:
CHAPTER 4.4 HISTOPATHOLOGICAL CHANG
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Platc 2 Plate 3 Plate 4 Plate 5 Pla
Page 119 and 120:
Platc X Plate 9 Plate 10 Plate 11 P
Page 121 and 122:
Plate w: Section of Testes of norma
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4.4.2.1.5 Brain The control animals
Page 126 and 127:
Plate ICt Section of Kidney of infe
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4.4.2.2 Histopathological changes i
Page 130 and 131:
Plate 32
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The mf could not be seen in spleen
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ain, it decreased from 0 day itself
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inflammatory nature indicative of c
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BIBLIOGRAPHY Ackerman, S.J., Gleich
Page 143 and 144:
Case, T., Leis, B., Witte, M., Way,
Page 145 and 146:
Drabkin, D.L.R. and Austin, J.H. (1
Page 147 and 148:
Fukuota, M., Zhou, Y. and Tanaka.(l
Page 149 and 150:
Jacob, H.S. and Lux, S.E. (1968). D
Page 151 and 152:
Linda, I. and Mayeda, B. (1974). Th
Page 153 and 154:
Murray, H.W. (1981). Susceptibility
Page 155 and 156:
Santiago- Stevenson, D., Oliver-Gon
Page 157 and 158:
Tate, S.S., Thomson, G.A. and Meist
Page 159 and 160:
Zaini, M., Ramachandran, C.P. and E
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