effect of infection of the filarial parasite brugia malayi - Pondicherry ...

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Plate a Section of Brain of infected p up showing congestion of meningeal blood vessel (Haernatoxylin and Eosin IOOX). Plate 3: Section of Brain of infected pup showing widening of Varsho-Robins perivascular space (Haernatoxylin and Eosin 400X). Plate a Section of Brain of infected group showing microfilaria in the blood vessel (Haematoxylin and Eosin 400X). Plate fa: Section of Brain of infected group showing microfilaria (Haematoxylin and Eosin 400X). Plate a: Section of Brain of infected pup showing infilhation of glial cells around microfilaria (Haematoxylin and Eosin 400X). Plate 15 Won of hdncy of ~nfected group showing severe vacuolar degeneration in the tubular epithelial cells (Haernatoxylin and Eosin 250X).
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EFFECT OF INFECTION OF THE FILARIAL
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I wish to express my deep sense of
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1. INTRODUCTlON 2. REVIEW OF LlTERA
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As stated earlier, the host immune
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13 Testicular changes Testosterone
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2. REVIEW OF LITERATURE Filariasis
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2.2 Clinical signs Inflammalation o
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the tegument by the release of thei
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the compound kills the filarial wor
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3. MATERIALS AND METHODS COLONY MAI
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Ragenb 1. Tris-HCI buffer . : 0.1 M
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3. Reduced glutathione : 30 mM To I
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4.1.1.6 Glucose-6-phosphate dehydro
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absorbance of the clear supernatant
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-eats I. Lowry's reagent :Solution
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4.1.2.1 Changes in antioxidant enzy
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Fig.3: Effect of B.malayi on SOD in
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Fig.9: Effect of B.rnalayi on GST i
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Fig.12: Effect of 6.rnalayi on GPx
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Fig. 18: Effect of B.malayi on G6PD
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12- 3 m- 15- lor, Fig.21: Effect of
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Fig.27: Effect of B.malayi on Ascor
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4.1.2.3 Change in the antioxidant e
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Fig.35: Effect of B.malayi on CAT i
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m 20 0) - 15 9 g 10 il! 5 0 Fig.39:
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30 25 8 - a 20 2 15 C I 10 I 5 0 35
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Fig.45: Effect of B.maiayi on GSH i
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Fig.49: Effect of B.malayi on Vit-C
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4.1.3 DISCUSSION 4.1 3.1.1 Toxic ox
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1973). The two major systems of LPO
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1981), and their increase in human
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1 0 Fig.58:Relationship between cha
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1 - 0- ' 1 5 - 6 - 7 - Fig.63:Relat
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Catalase had been reported to be re
Page 73 and 74: - Fig.68:Relationship between chang
Page 75 and 76: esults in its reduced activity (Con
Page 77 and 78: g 20- :I-. F1g.70:Relationship betw
Page 79 and 80: 12, - I 0 U) Q 4 2 0 - + - Fig.75:R
Page 81 and 82: $ Fig.80:Relationship between chang
Page 83 and 84: Fig.85:Relationship between change
Page 85 and 86: V) (3 :; - Fig.9O:Relationship betw
Page 87 and 88: A reduction in the total thiol cont
Page 89 and 90: 2 5- Fig.98:Relationship between ch
Page 91 and 92: Fig. 103:Relationship between chang
Page 93 and 94: 4.2.1.1 N ay ATPase Reagents Nay AT
Page 95 and 96: Reagents 1. Acetylcholine bromide :
Page 97 and 98: To 1.5 ml of carbonate buffer, 1.5
Page 99 and 100: 4.2.1.10 Differential leucocyte cou
Page 101 and 102: increase in the control animals (Fi
Page 103 and 104: - Fig.110: Effect of 6. malayi on H
Page 105 and 106: efflux and thereby alter the membra
Page 107 and 108: with i n d lymphocytes and decrease
Page 109 and 110: Tubes were labeled for calibrators,
Page 111 and 112: Fig.114: Effect of B, malayi on GTP
Page 113 and 114: 433 DISCUSSION Testosterone is a se
Page 115 and 116: CHAPTER 4.4 HISTOPATHOLOGICAL CHANG
Page 117 and 118: Platc 2 Plate 3 Plate 4 Plate 5 Pla
Page 119 and 120: Platc X Plate 9 Plate 10 Plate 11 P
Page 121 and 122: Plate w: Section of Testes of norma
Page 123: 4.4.2.1.5 Brain The control animals
Page 127 and 128: I'iatc 26 Plate 2:
Page 129 and 130: Plate 31: Section of Testes of infe
Page 131 and 132: pahangi and no lesions in the kidne
Page 134 and 135: 5. SUMMARY The effect of B.mala)ti
Page 136 and 137: ain, heart and lungs. However, in t
Page 139: 6. CONCLUSION B. malayi infection o
Page 142 and 143: Babior, B.M., Kipnes, R.S. and Curn
Page 144 and 145: Condell, R.A. and Tappel, A.L. (198
Page 146 and 147: Fairfield, AS., Abosch, A., Ram, A.
Page 148 and 149: Hams, H, and Hopkinson, D.A. (1978)
Page 150 and 151: Konigk, E. And Mirtsch, S. (1977).
Page 152 and 153: Marshall, G.R., Wickings, E.J. and
Page 154 and 155: Panicker, N.V. and Zyer, G.Y.N. (19
Page 156 and 157: Skinner, M.K. (1987). Cell-cell int
Page 158 and 159: Vincent, A.L., Frammes, S.P. and As
Page 160: APPENDIX Haematological values of M
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