effect of infection of the filarial parasite brugia malayi - Pondicherry ...

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Marshall, G.R., Wickings, E.J. and Nieschlag, E. (1984). Testosterone can initiate spermatogenesis in an immature non-human primate, Macaca fascicularis. Endocrinol. 114: 2228. Mathews, S.T. and Selvam, ~.'(1991a). Effect of radical treatment on erythrocytic lipid peroxidation in Plasmodium viva infected malaria patients. Biochem. Int. 25 (2): 211. Mathews, S.T. and Selvam, R. (1993). Changes in glutathione metabolic enzymes in erythrocytes of Plasmodium viva infected patients. CIin Chim. Acla. 219: 159. Mathews, S.T., Kumaresan, P.R. and Selvam, R. (1991). Glucose-bghosphate dehydrogenase deficiency and malaria. A study on North Madras population. J. Cornm. Dis. 23 (3): 178. McCall, J.W., Malone, J.B., Hyang, E. and Thompson, P.E. (1973). Mongolian jirds (Meriones unguiculatus) infected with B. pahangi by the intraperitoneal route: A rich source of developing larvae, adult filariae, and microfilaria. Vet. Parasirol. 59 (3): 436. McCord, J.M. and Fridovich, 1. (1969). Superoxide dismutase. An enzymatic function for erythrocuprein (Hernocuprein). 244 (22): 6049. McCormick, J.R., Harkin, M.M., Johnson, K.J. and Ward, P.A. (1 98 1). Suppression by superoxide dismutase of immune complex induced pulmonary alveolitis and dermal inflammation. Amer. J. Pathol. 102: 55. McIlwain, H. (1969). In: Basic mechanisms of epilepsies, Jasper, H.H., Ward, .A.A. and Pope, A, Eds., Little Brown, Boston, pp 83. Miale, J.B. (1972). Appendix methods. In: Laboratory medicine haematology. 4th ed., Mosby, C.V.co., St. Louis, pp 904, 1 198, 1200. Mitchell, C.D., Mitchell, W.B. and Hanahan, D.J. (1965). Enzyme and haemoglobin retention in human erythrocyte stroma. Biochem. Biophys. Acta. 104: 348. Morikov, K.N., Herrera, M., Pascual, C. and Gonzalez, R. (1991). The antioxidative activity of drugs in the liver microsomal system of rats. Biol. yauki. 12: 19. Moron, MS., Depierre, J.W. and Mannerviek, B. (1979). Levels of glutathione and glutathione-S-transferase activities in rat lung and liver. Biochem. Biophys. Acta. 582: 67. Murthy, P.K., Murthy, P.S., Tyagi, K. and Chatterjee, R.K. (1997). Fate of infective larvae of B. malayi in the peritoneal cavity of M. natalensis and Meriones unguiculatus. Folia parasit. 44 (4): 302.
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EFFECT OF INFECTION OF THE FILARIAL
Page 4 and 5:
I wish to express my deep sense of
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1. INTRODUCTlON 2. REVIEW OF LlTERA
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As stated earlier, the host immune
Page 11 and 12:
13 Testicular changes Testosterone
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2. REVIEW OF LITERATURE Filariasis
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2.2 Clinical signs Inflammalation o
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the tegument by the release of thei
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the compound kills the filarial wor
Page 22:
3. MATERIALS AND METHODS COLONY MAI
Page 25 and 26:
Ragenb 1. Tris-HCI buffer . : 0.1 M
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3. Reduced glutathione : 30 mM To I
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4.1.1.6 Glucose-6-phosphate dehydro
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absorbance of the clear supernatant
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-eats I. Lowry's reagent :Solution
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4.1.2.1 Changes in antioxidant enzy
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Fig.3: Effect of B.malayi on SOD in
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Fig.9: Effect of B.rnalayi on GST i
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Fig.12: Effect of 6.rnalayi on GPx
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Fig. 18: Effect of B.malayi on G6PD
Page 45 and 46:
12- 3 m- 15- lor, Fig.21: Effect of
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Fig.27: Effect of B.malayi on Ascor
Page 49 and 50:
4.1.2.3 Change in the antioxidant e
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Fig.35: Effect of B.malayi on CAT i
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m 20 0) - 15 9 g 10 il! 5 0 Fig.39:
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30 25 8 - a 20 2 15 C I 10 I 5 0 35
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Fig.45: Effect of B.maiayi on GSH i
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Fig.49: Effect of B.malayi on Vit-C
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4.1.3 DISCUSSION 4.1 3.1.1 Toxic ox
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1973). The two major systems of LPO
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1981), and their increase in human
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1 0 Fig.58:Relationship between cha
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1 - 0- ' 1 5 - 6 - 7 - Fig.63:Relat
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Catalase had been reported to be re
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- Fig.68:Relationship between chang
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esults in its reduced activity (Con
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g 20- :I-. F1g.70:Relationship betw
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12, - I 0 U) Q 4 2 0 - + - Fig.75:R
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$ Fig.80:Relationship between chang
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Fig.85:Relationship between change
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V) (3 :; - Fig.9O:Relationship betw
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A reduction in the total thiol cont
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2 5- Fig.98:Relationship between ch
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Fig. 103:Relationship between chang
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4.2.1.1 N ay ATPase Reagents Nay AT
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Reagents 1. Acetylcholine bromide :
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To 1.5 ml of carbonate buffer, 1.5
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4.2.1.10 Differential leucocyte cou
Page 101 and 102: increase in the control animals (Fi
Page 103 and 104: - Fig.110: Effect of 6. malayi on H
Page 105 and 106: efflux and thereby alter the membra
Page 107 and 108: with i n d lymphocytes and decrease
Page 109 and 110: Tubes were labeled for calibrators,
Page 111 and 112: Fig.114: Effect of B, malayi on GTP
Page 113 and 114: 433 DISCUSSION Testosterone is a se
Page 115 and 116: CHAPTER 4.4 HISTOPATHOLOGICAL CHANG
Page 117 and 118: Platc 2 Plate 3 Plate 4 Plate 5 Pla
Page 119 and 120: Platc X Plate 9 Plate 10 Plate 11 P
Page 121 and 122: Plate w: Section of Testes of norma
Page 123 and 124: 4.4.2.1.5 Brain The control animals
Page 126 and 127: Plate ICt Section of Kidney of infe
Page 128 and 129: 4.4.2.2 Histopathological changes i
Page 130 and 131: Plate 32
Page 132: The mf could not be seen in spleen
Page 135 and 136: ain, it decreased from 0 day itself
Page 137: inflammatory nature indicative of c
Page 141 and 142: BIBLIOGRAPHY Ackerman, S.J., Gleich
Page 143 and 144: Case, T., Leis, B., Witte, M., Way,
Page 145 and 146: Drabkin, D.L.R. and Austin, J.H. (1
Page 147 and 148: Fukuota, M., Zhou, Y. and Tanaka.(l
Page 149 and 150: Jacob, H.S. and Lux, S.E. (1968). D
Page 151: Linda, I. and Mayeda, B. (1974). Th
Page 155 and 156: Santiago- Stevenson, D., Oliver-Gon
Page 157 and 158: Tate, S.S., Thomson, G.A. and Meist
Page 159 and 160: Zaini, M., Ramachandran, C.P. and E
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