effect of infection of the filarial parasite brugia malayi - Pondicherry ...

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Hams, H, and Hopkinson, D.A. (1978). The enzymes. In: Handbook of enzyme electrophoresis in human genetics. North-Holland Publishing Company, Netherlands. PP 4. Hawking, F. (1979). ~iethilcarbamazine and new compounds for the treatment of filariasis. Adv. Pharmacol. Chemoihrr. 16: 130. Hawking, F., Sewell, J.P, and Thurston, J.P. (1950). The mode action of heterazan on filarial worms. Br. J Pharmacol. Chemother. 5: 217. Hestrin, S. (1949). The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine and its analytical application. J. Biol. Chem. 180: 249. Hewitt, R.I., White, E., Wallace. W.S., Stewart, H.W., Kushner, S, and Subbarow, Y.J. (1947). Experimental chemotherapy of filariasis, 11 Effect of piperazine derivatives against naturally acquired filarial infection in cotton rats and dogs. J. Lab. Clin. Med. 32: 1304. Hjerten, S. and Pan, H. (1983). Purification and characterization of two forms of a low affinity calcium- ATPase from erythrocyte membrane. Biochem. Biophys. Acta. 728: 281. Hochstein, H. and Emster, P. (1963). ADP-activated lipid peroxidation coupled to the TNPH oxidase systems of microsomes. Biochem. Biophys. Res. Comm. 12: 388. Hodgen, G.D. (1983). Endocrine control of adult testicular function. In: Testis. Burger, H. And deKretser, D. Ed., Raven Press, New York. pp 137. Hodgen, G.D. and Sherins, R.J. (1973). Enzymes as markers of testicular growth and development in the rat. Endocrinol. 93: 985. Hodgson, E.K. and Fridovich, 1. (1975). The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide chemiluminescence and peroxidation. Biochem. 14: 5299. Howard, R.J. and Sawyer, W.H. (1980). Changes in the membrane microviscosity of mouse red blood cells infected with P. berghei detected using n-(9-anthroxyloxy) fatty acid fluorescent probes. Parasii. 80: 331. Irwin, M.1, and Hutchins, B.K. (1976). A conspectus of research on vitamin C requirements of man. J. Nutr. 106: 821. Itoh, R. and Ozasa, H. (1985). Changes in serum lactate dehydrogenase isozyme-X activity observed after cadmium administration. Toxicology Letters. 28 (2-3): 157. Jacob, H.S. and Jandl, J.H. (1962). Effects of sulphydryl inhibition on RBC. 11. Studies in vivo. J. Clin. bvest. 41 : 15 14.
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EFFECT OF INFECTION OF THE FILARIAL
Page 4 and 5:
I wish to express my deep sense of
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1. INTRODUCTlON 2. REVIEW OF LlTERA
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As stated earlier, the host immune
Page 11 and 12:
13 Testicular changes Testosterone
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2. REVIEW OF LITERATURE Filariasis
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2.2 Clinical signs Inflammalation o
Page 18 and 19:
the tegument by the release of thei
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the compound kills the filarial wor
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3. MATERIALS AND METHODS COLONY MAI
Page 25 and 26:
Ragenb 1. Tris-HCI buffer . : 0.1 M
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3. Reduced glutathione : 30 mM To I
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4.1.1.6 Glucose-6-phosphate dehydro
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absorbance of the clear supernatant
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-eats I. Lowry's reagent :Solution
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4.1.2.1 Changes in antioxidant enzy
Page 37 and 38:
Fig.3: Effect of B.malayi on SOD in
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Fig.9: Effect of B.rnalayi on GST i
Page 41 and 42:
Fig.12: Effect of 6.rnalayi on GPx
Page 43 and 44:
Fig. 18: Effect of B.malayi on G6PD
Page 45 and 46:
12- 3 m- 15- lor, Fig.21: Effect of
Page 47 and 48:
Fig.27: Effect of B.malayi on Ascor
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4.1.2.3 Change in the antioxidant e
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Fig.35: Effect of B.malayi on CAT i
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m 20 0) - 15 9 g 10 il! 5 0 Fig.39:
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30 25 8 - a 20 2 15 C I 10 I 5 0 35
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Fig.45: Effect of B.maiayi on GSH i
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Fig.49: Effect of B.malayi on Vit-C
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4.1.3 DISCUSSION 4.1 3.1.1 Toxic ox
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1973). The two major systems of LPO
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1981), and their increase in human
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1 0 Fig.58:Relationship between cha
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1 - 0- ' 1 5 - 6 - 7 - Fig.63:Relat
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Catalase had been reported to be re
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- Fig.68:Relationship between chang
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esults in its reduced activity (Con
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g 20- :I-. F1g.70:Relationship betw
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12, - I 0 U) Q 4 2 0 - + - Fig.75:R
Page 81 and 82:
$ Fig.80:Relationship between chang
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Fig.85:Relationship between change
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V) (3 :; - Fig.9O:Relationship betw
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A reduction in the total thiol cont
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2 5- Fig.98:Relationship between ch
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Fig. 103:Relationship between chang
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4.2.1.1 N ay ATPase Reagents Nay AT
Page 95 and 96:
Reagents 1. Acetylcholine bromide :
Page 97 and 98: To 1.5 ml of carbonate buffer, 1.5
Page 99 and 100: 4.2.1.10 Differential leucocyte cou
Page 101 and 102: increase in the control animals (Fi
Page 103 and 104: - Fig.110: Effect of 6. malayi on H
Page 105 and 106: efflux and thereby alter the membra
Page 107 and 108: with i n d lymphocytes and decrease
Page 109 and 110: Tubes were labeled for calibrators,
Page 111 and 112: Fig.114: Effect of B, malayi on GTP
Page 113 and 114: 433 DISCUSSION Testosterone is a se
Page 115 and 116: CHAPTER 4.4 HISTOPATHOLOGICAL CHANG
Page 117 and 118: Platc 2 Plate 3 Plate 4 Plate 5 Pla
Page 119 and 120: Platc X Plate 9 Plate 10 Plate 11 P
Page 121 and 122: Plate w: Section of Testes of norma
Page 123 and 124: 4.4.2.1.5 Brain The control animals
Page 126 and 127: Plate ICt Section of Kidney of infe
Page 128 and 129: 4.4.2.2 Histopathological changes i
Page 130 and 131: Plate 32
Page 132: The mf could not be seen in spleen
Page 135 and 136: ain, it decreased from 0 day itself
Page 137: inflammatory nature indicative of c
Page 141 and 142: BIBLIOGRAPHY Ackerman, S.J., Gleich
Page 143 and 144: Case, T., Leis, B., Witte, M., Way,
Page 145 and 146: Drabkin, D.L.R. and Austin, J.H. (1
Page 147: Fukuota, M., Zhou, Y. and Tanaka.(l
Page 151 and 152: Linda, I. and Mayeda, B. (1974). Th
Page 153 and 154: Murray, H.W. (1981). Susceptibility
Page 155 and 156: Santiago- Stevenson, D., Oliver-Gon
Page 157 and 158: Tate, S.S., Thomson, G.A. and Meist
Page 159 and 160: Zaini, M., Ramachandran, C.P. and E
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