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CMS Manual System - Louisiana Department of Health and Hospitals

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Medication Issues <strong>and</strong> Concerns<br />

darbepoetin<br />

erythropoietin<br />

should precede or accompany the use <strong>of</strong> this<br />

medication<br />

Monitoring<br />

Iron Indications<br />

Laxatives<br />

All categories including bulk<br />

producing laxatives,<br />

hyperosmolar agents, saline<br />

laxatives, stimulant<br />

Use must be monitored according to specific<br />

manufacturer‘s instructions including blood<br />

pressure, baseline serum iron or ferritin level, <strong>and</strong><br />

frequent complete blood count (CBCs) to permit<br />

tapering or discontinuation when<br />

hemoglobin/hematocrit reaches or exceeds target<br />

ranges<br />

Adverse Consequences<br />

May cause or worsen hypertension<br />

Excessive dose or duration can lead to<br />

polycythemia, dangerous thrombotic events<br />

including myocardial infarction <strong>and</strong> stroke<br />

Iron therapy is not indicated in anemia <strong>of</strong> chronic<br />

disease when iron stores <strong>and</strong> transferrin levels are<br />

normal or elevated<br />

Dosage/Duration<br />

Clinical rationale should be documented for longterm<br />

use (greater than two months) or<br />

administration more than once daily for greater<br />

than a week, because <strong>of</strong> side effects <strong>and</strong> the risk <strong>of</strong><br />

iron accumulation in tissues<br />

Monitoring<br />

Baseline serum iron or ferritin level <strong>and</strong> periodic<br />

CBC or hematocrit/ hemoglobin<br />

Adverse Consequences<br />

May cause constipation, dyspepsia<br />

Can accumulate in tissues <strong>and</strong> cause multiple<br />

complications if given chronically despite normal<br />

or high iron stores<br />

Adverse Consequences<br />

May cause flatulence, bloating, abdominal pain<br />

Bulk forming laxatives <strong>and</strong> stool s<strong>of</strong>teners may<br />

cause accumulation <strong>of</strong> stool <strong>and</strong> possible bowel

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