university of kwazulu-natal faculty of science and agriculture school ...

Figure 9: Formation of ring A from GGPP 10
Figure 10: Biosynthetic pathway for bi-, tri- and tetracyclic diterpenes 11
Figure 11: Biosynthesis of beyerane, trachylobane, atisane and aconane diterpenes 12
Figure 12: Synthesis of abietadiene 13
Figure 13: Plectranthus hadiensis 16
Figure 14: Illustration of the 2 clades within the Plectranthus species, categorized according to their
phylogeny
Figure 15: Plectranthus hadiensis in bloom 94
Figure 16: Chair conformation of compound I showing the relationship between H-5, H-6 and H-7 107
Figure 17: Fragment of Ring C 114
Figure 18: NOESY correlations for compound III 115
Figure 19: NOESY correlations for compound IV 124
Figure 20: Dose response curve for 7β-acetoxy-6β-hydroxyroyleanone (I) against TK-10, UACC-62
and MCF-7 cell lines
Figure 21: Dose response curve for 7β,6β-dihydroxyroyleanone (II) against TK-10, UACC-62 and
MCF-7 cell lines
Figure 22: Dose response curve for ent-pimara-8(14),15-diene-3β,11α-diol (III) against TK-10,
UACC-62 and MCF-7 cell lines
Figure 23: Dose response curve for 2α,3α,19α-trihydroxyurs-12-en-28-oic acid (IV) against TK-10,
UACC-62 and MCF-7 cell lines
List of Spectra
Compound I, 7β-acetoxy-6β-hydroxyroyleanone 161
Spectrum 1a: 1 H NMR spectrum of compound I 162
Spectrum 1b: 13 C NMR spectrum of compound I 163
Spectrum 1c: Expanded 13 C NMR spectrum of compound I 164
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