university of kwazulu-natal faculty of science and agriculture school ...

4
20
10
O
H
19 18
6 7
OH
OH
C
13
R
O
R
(33) α-OH
(34) β-OH
(36) α-OC(O)CH3
(37) β-OC(O)CH3
(38) α-OCH(O)
The purpose of this study was to perform phytochemical analyses on the stem and leaf
material of Plectranthus hadiensis in the hope of isolating abietane diterpenes to test
against Enterococcus faecalis and Pseudomonas aeruginosa bacterial microorganisms
and breast (MCF-7), renal (TK-10) and melanoma (UACC-62) cancer cell lines. Since
there has been no reports of compounds 34 and 37 possessing any biological activity, it
was decided to evaluate these compounds for antibacterial and anticancer activity. We
hope to compare our activity against E. faecalis with that reported in the literature and to
report for the first time the antibacterial activity. We also hope to compare the anticancer
activity of known compounds from P. hadiensis with that in the literature and report on
the anticancer activity of any new compounds isolated from P. hadiensis.
Research has been conducted previously on the aerial parts, roots and leaves (Mothana et
al., 2008; Laing et al., 2006), but there has been no phytochemical reports on the stem
material. Since the aerial parts, roots and leaves of P. hadiensis were found to possess
antiradical, antibacterial and antifungal activity (Mothana et al., 2008; Laing et al., 2006),
this plant made an interesting phytochemical and pharmacological subject.
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