university of kwazulu-natal faculty of science and agriculture school ...

Net Growth (%)
150
100
50
0
-50
-100
-150
Compound 3
0.01 0.10 1.00 10.00 100.00
Concentration (µg/ml)
Cell line 1 (TK-10) Cell line 2 (UACC) Cell line 3 (MCF)
Figure 22: Dose response curve for ent-pimara-8(14),15-diene-3β,11α-diol (III) against TK-
10, UACC-62 and MCF-7 cell lines
Compound IV, the only triterpenoid tested was only capable of inhibiting the growth
(GI50) of the melanoma and breast cancer cell lines at concentrations which classified this
compound as inactive and showed no potential killing activity (LC50 or LC100) even at
100µg/mL.
Net Growth (%)
150
100
50
0
-50
-100
-150
Compound 4
0.01 0.10 1.00 10.00 100.00
Concentration (µg/ml)
Cell Line 1 (TK-10) Cell Line 2 (UACC) Cell Line 3 (MCF)
Figure 23: Dose response curve for 2α,3α,19α-trihydroxyurs-12-en-28-oic acid (IV) against TK-10,
UACC-62 and MCF-7 cell lines
151