Plectranthus myrianthus Briq.; cis- <strong>and</strong> trans-A/B-6,7-dioxoroyleanone, Helvetica Chimica Acta, 60, 2770-2779 Miyase, T., Ruedi, P. <strong>and</strong> Eugster, C.H. (1977b) Diterpenoid leaf-gl<strong>and</strong> pigments from Labiatae: 3β-acetoxyfuerstione, nilgherron A <strong>and</strong> nilgherron B, new quinomethanes from Plectranthus nilgherricus Benth.; absolute configuration <strong>of</strong> fuerstione, Helvetica Chimica Acta, 60, 2789-2803 Miyase, T., Yoshizaki, F., Kabengele, N., Ruedi, P. <strong>and</strong> Eugster, C. H. (1979) Structures <strong>of</strong> 13 diterpenes (coleones) from Solenostemon sylvaticus <strong>and</strong> Coleus garckeanus (Labiatae) leaf gl<strong>and</strong>s, Helvetica Chimica Acta, 62, 2374-2383 Moir, M., Ruedi, P. <strong>and</strong> Eugster, C.H. (1973a) Diterpenoid hydroquinones from Coleus somaliensis (S. Moore): Coleons H, I <strong>and</strong> K, Helvetica Chimica Acta, 56, 2534-2539 Moir, M., Ruedi, P. <strong>and</strong> Eugster, C.H. (1973b) Diterpenoids from Coleus somaliensis (S. Moore): Coleons G <strong>and</strong> J, Helvetica Chimica Acta, 56, 2539-2548 Mothana, R.A.A., Abdo, S.A.A., Hasson, S., Althawab, F.M.N., Alaghbari, S.A.Z. <strong>and</strong> Lindequist, U. (2008) Antimicrobial, antioxidant <strong>and</strong> cytotoxic activities <strong>and</strong> phytochemical screening <strong>of</strong> some Yeni medicinal plants, eCAM Advance Access, pp 1-8 Motoyuki, M. (2007) Functional food for the bowel movement improvement, (Genex K. K., Japan) Jpn. Kokai Tokkyo Koho, Patent number JP 2007097572, Patent Application number JP 2005-373060, 6pp (abstract from Scifinder Scholar 2007) Murthy, P.S., Ramalakshmi, K. <strong>and</strong> Srinivas, P. (2009) Fungitoxic activity <strong>of</strong> Indian borage (Plectranthus amboinicus) volatiles, Food Chemistry, 114, 1014-1018 Narukawa, Y., Shimizu, N., Shimotohno, K. <strong>and</strong> Takeda, T. (2001) Two new diterpenoids from Plectranthus nummularius Briq., Chemical <strong>and</strong> Pharmaceutical Bulletin, 49, 1182-1184 Neuwinger, H.D. (2000) African Traditional Medicine, A Dictionary <strong>of</strong> Plant Use <strong>and</strong> Applications, Mepharm Scientific Publishers, Stuttgart, pp 406-408 Nyila, M.A., Leonard, C.M., Hussein, A.A. <strong>and</strong> Lall, N. (2009) Bioactivities <strong>of</strong> Plectranthus ecklonii constituents, Natural Product Communications, 4, 1177-1180 (abstract from Scifinder Scholar 2007) 87
Oliveira, P.M., Alves, R.B., Ferreira, A.A., Brasileiro, B.G., Takahashi, J.A., Lage, G.L.C., Ferraz, V.P., Silveira, D. <strong>and</strong> Raslan, D.S. (2007) Composition <strong>and</strong> antimicrobial activity <strong>of</strong> essential oil from Plectranthus ornatus Codd, Recent Progress in Medicinal Plants, 17, 395-409 (abstract from Scifinder Scholar 2007) Oliveira, P.M., Souza J.N.C., Lage, G.L.C., Alves, R.B., Silveira, D. <strong>and</strong> Raslan, D.S. (2007) Ethnobotany, pharmacology <strong>and</strong> phytochemistry <strong>of</strong> Plectranthus (Lamiaceae), Recent Progress in Medicinal Plants, 17, 363-393 (abstract from Scifinder Scholar 2007) Omolo, M.O., Okinyo, D., Ndiege, I.O., Lw<strong>and</strong>e, W. <strong>and</strong> Hassanali, A. (2005) Fumigant toxicity <strong>of</strong> the essential oils <strong>of</strong> some African plants against Anopheles gambiae sensu stricto, Phytomedicine, 12, 241-246 Onifade, A.K., Fatope, M.O., Deadman, M.L. <strong>and</strong> Al-Kindy, S.M.Z. (2008) Nematicidal activity <strong>of</strong> Haplophyllum tuberculatum <strong>and</strong> Plectranthus cylindraceus oils against Meloidogyne javanica, Biochemical Systematics <strong>and</strong> Ecology, 36, 679-683 Pages, N., Salazar, M., Chamorro, G., Fournier, G., Paris, M., Dumitresco, S.M. <strong>and</strong> Boudene, C. (1988) Teratological evaluation <strong>of</strong> Plectranthus fruticosus leaf essential oil, Planta medica, 54, 296-298 Paton, A.J., Springate, D., Suddee, S., Otieno, D., Grayer, R.J., Harley, M.M., Willis, F., Simmonds, M.S.J., Powell, M.P. <strong>and</strong> Savolainen, V. (2004) Phylogeny <strong>and</strong> evolution <strong>of</strong> basils <strong>and</strong> allies (Ocimeae, Labiatae) based on three plastid DNA regions, Molecular Phylogenetics <strong>and</strong> Evolution, 31, 277-299 Periyanayagam, K., Nirmala, D.K., Suseela, L., Uma, A. <strong>and</strong> Ismail, M. (2008) In vivo antimalarial activity <strong>of</strong> leaves <strong>of</strong> Plectranthus amboinicus (Lour.) Spreng on Plasmodium berghei yoelii, The Journal <strong>of</strong> Communicable Diseases, 40, 121-125 (abstract from Scifinder Scholar 2007) Rabe, T. <strong>and</strong> van Staden, J. (1998) Screening <strong>of</strong> Plectranthus species for antibacterial activity, South African Journal <strong>of</strong> Botany, 64, 62-65 Ragasa, C.Y., Templora, V.F. <strong>and</strong> Rideout, J.A. (2001) Diastereomeric diterpenes from Coleus blumei, Chemical <strong>and</strong> Pharmaceutical Bulletin, 49, 927-929 88
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UNIVERSITY OF KWAZULU-NATAL FACULTY
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Preface The experimental work descr
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Acknowledgements First and foremost
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GC-MS - gas chromatography-mass spe
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Table 19: NMR data of compound III
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Spectrum 1d: Expanded DEPT spectrum
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Compound V, stigmasterol 217 Spectr
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2 19 1 4 18 O 20 5 Structures of co
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3.4 Results and Discussion of the c
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compounds are also classified as tr
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1 H CO2H 19 20 CHO 18 10 5 H 12 14
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may be referred to as a norabietane
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In the mevalonic acid pathway, the
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N thiamine diphosphate (TPP) O OH N
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in the kauranes. From the kauranes,
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References Abad, A., Agullo, C., Cu
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The flower colour varies among the
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Clade 1 unplaced groups Group A: Pl
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different medical conditions and in
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Plectranthus species Skin condition
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Plectranthus species Heart, circula
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Use of the minimum inhibitory conce
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Plectranthus species Coleus kiliman
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Plectranthus species Extraction med
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Plectranthus species Coleus kiliman
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Methanol, ethanol and water seem to
- Page 53 and 54: Plectranthus species P. amboinicus
- Page 55 and 56: Plectranthus species P. amboinicus
- Page 57 and 58: variation is observed within ring B
- Page 59 and 60: Compound Name Synonym 39 40 41 42 4
- Page 61 and 62: compounds (Table 6b). Depending on
- Page 63 and 64: Table 6c: Royleanone-type abietanes
- Page 65 and 66: R 1 R2CH2 19 O H 3CCO 19 O H 6 12 O
- Page 67 and 68: Compound Name Synonym 81 82 83 84 8
- Page 69 and 70: Compound Name Synonym 104 105 106 1
- Page 71 and 72: R 1 19 3 3 1 18 1 18 20 20 O H O H
- Page 73 and 74: educed furan ring. The linear side
- Page 75 and 76: Compound Name Synonym HCO O 128 129
- Page 77 and 78: Thirty-six compounds (131-167) havi
- Page 79 and 80: Compound Name Synonym 147 148 HO HO
- Page 81 and 82: In compounds 149-165 (Table 9b), an
- Page 83 and 84: Compound Name Synonym 163 164 165 R
- Page 85 and 86: Table 9c: Coleon-type abietanes wit
- Page 87 and 88: 1 18 3 20 4 O 5 19 R 1 R2 11 9 10 A
- Page 89 and 90: The majority of the abietanes isola
- Page 91 and 92: Plectranthus species Plant part Com
- Page 93 and 94: The leaves seem to be the most freq
- Page 95 and 96: Table 14 contains six abietanes iso
- Page 97 and 98: References Abdel-Mogib, M., Albar,
- Page 99 and 100: Cos, P., Hermans, N., de Bryne, T.,
- Page 101 and 102: Hulme, M. (1954) Wild flowers of Na
- Page 103: Lingling, X., Jie, L., Weijia, L. a
- Page 107 and 108: Ruedi, P. and Eugster, C. H. (1977)
- Page 109 and 110: Ulubelen, A., Birman, H., Oksuz, S.
- Page 111 and 112: Chapter 3 Extractives from Plectran
- Page 113 and 114: 4 20 10 O H 19 18 6 7 OH OH C 13 R
- Page 115 and 116: a few cases (specifically stated in
- Page 117 and 118: The leaves (184.63g) were air-dried
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- Page 121 and 122: 3.4.1 Structural elucidation of Com
- Page 123 and 124: esonance showed HMBC correlations t
- Page 125 and 126: esonance at δC 185.76 of C-14 is a
- Page 127 and 128: Position Moiety Compound I 3 CH2 5
- Page 129 and 130: Table 18: 13 C NMR data for compoun
- Page 131 and 132: The equatorial methyl group at C-4,
- Page 133 and 134: The proton NMR data for compound II
- Page 135 and 136: Position 6 7 Compound III (400MHz)
- Page 137 and 138: 3.4.3 Structure elucidation of Comp
- Page 139 and 140: showed HMBC correlations to another
- Page 141 and 142: H HO 3 OH H 2 4 24 eq 1 23 5 ax Hax
- Page 143 and 144: HO HO Position 2 23 4 10 24 25 26 9
- Page 145 and 146: Position Compound IV 4.1 4.2 4.3 b
- Page 147 and 148: multiplet at δH 1.91 (H-21) and a
- Page 149 and 150: 1 H Position Compound VI Burns et a
- Page 151 and 152: Ultraviolet spectrum (λ max): 192n
- Page 153 and 154: References Ansell, S.M. (1989) The
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Laing, M.D., Drewes, S.E. and Gurla
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van Vuuren, S. (2007) The antimicro
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Since the 7α-isomers of compounds
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eing incubated for 24 hours at 37°
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This indicated that the dihydroxy c
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acetic acid and air drying the plat
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whereas GI50 values for the renal a
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Table 28: Growth inhibition values
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Gaspar-Marques, C., Duarte, M.A., S
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Chapter 5 Conclusion The aim of thi
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References Abdel-Mogib, M., Albar,
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Table of Contents Page Compound I,
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Compound II, 6β,7β-dihydroxyroyle
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Compound IV, euscaphic acid HO HO 2
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HO Compound VI, lupeol 3 24 25 26 2
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HO 218
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HO 220
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222
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225
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227