A systematic review and economic model of the effectiveness and ...

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Feedback The HTA Programme and the authors would like to know your views about this report. The Correspondence Page on the HTA website (http://www.hta.ac.uk) is a convenient way to publish your comments. If you prefer, you can send your comments to the address below, telling us whether you would like us to transfer them to the website. We look forward to hearing from you. The National Coordinating Centre for Health Technology Assessment, Mailpoint 728, Boldrewood, University of Southampton, Southampton, SO16 7PX, UK. Fax: +44 (0) 23 8059 5639 Email: hta@hta.ac.uk http://www.hta.ac.uk ISSN 1366-5278
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A systematic review and economic mo
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A systematic review and economic mo
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Objectives: To assess the clinical
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Glossary and list of abbreviations
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Glossary Adverse effect An abnormal
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Glossary continued effects. Sometim
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Glossary continued point between tw
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Background Attention deficit hypera
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mean differences with 95% confidenc
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This review examines the clinical a
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4 Background E. Symptoms should not
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6 Background Concerta XL Concerta X
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8 Methods for reviewing effectivene
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10 Methods for reviewing effectiven
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Quantity and quality of research av
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TABLE 1 The quality of included stu
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TABLE 2 An overview of trials inclu
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TABLE 2 An overview of trials inclu
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TABLE 3 MPH low dose (≤15 mg/day)
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Quality of life Only one of the 12
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TABLE 5 MPH medium dose (15-30 mg/d
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Hyperactivity All nine studies that
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TABLE 6 Results for hyperactivity [
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Study Parallel trials Buitelaar 199
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TABLE 8 Results for hyperactivity [
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Study Parallel trials Gittelman-Kle
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TABLE 11 MPH high dose (>30 mg/day)
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TABLE 14 ER-MPH medium dose (20-40
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Study Crossover trials Stein 2003 S
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TABLE 19 Results for hyperactivity
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TABLE 22 MPH low dose (≤ 15 mg/da
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TABLE 24 MPH medium dose (15-30 mg/
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assessed by parents and teachers. I
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TABLE 30 DEX medium dose (10-20 mg/
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TABLE 38 DEX medium dose (10-20 mg/
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TABLE 41 DEX-SR plus non-drug inter
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Study Michelson 2001 [0.5] Michelso
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Hyperactivity Five trials (publishe
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TABLE 47 IR-MPH low-dose (≤ 15 mg
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STP. 77,78 Neither examined hyperac
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Adverse events No significant diffe
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did report that there were no signi
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Summary The one study in this categ
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showed persisting significant super
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easily rectified with dosage adjust
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Aim The aim of this chapter is to r
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only level of social disability tha
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did not include a ‘global’ HRQo
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might decrease but costs would be e
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1st line pharmacotherapy Response,
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TABLE 70 Data for weighted average
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The probabilistic results were used
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The review also uncovered a mis-ref
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TABLE 77 Results of sensitivity ana
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TABLE 80 Response a rates (%) estim
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TABLE 82 Drug costs used in the cos
Page 119 and 120: The review of the economic evidence
Page 121 and 122: Extrapolation A secondary analysis
Page 123 and 124: economic model rests on the assumpt
Page 125 and 126: TABLE 87 Data used in calculating w
Page 127 and 128: not fully probabilistic. The averag
Page 129 and 130: Probability cost-effective 1.0 0.9
Page 131 and 132: TABLE 93 Results of sensitivity ana
Page 133 and 134: Base case model Responder to MPH Re
Page 135 and 136: TABLE 96 Results of the sensitivity
Page 137 and 138: The same method for synthesising th
Page 139 and 140: TABLE 103 Results of the economic m
Page 141: of the 64 identified in the clinica
Page 144 and 145: 126 Discussion impact of active dru
Page 147: MPH, DEX and ATX improve hyperactiv
Page 151 and 152: 1. National Institute for Clinical
Page 153 and 154: tutoring on the behavior and achiev
Page 155 and 156: 91. Stein MA, Blondis TA, Schnitzle
Page 157 and 158: 140. Hill P, Taylor E. An auditable
Page 159 and 160: 189. Francis S, Fine J, Tannock R.
Page 161 and 162: 235. Rhodes SM, Coghill DR, Matthew
Page 163 and 164: hyperactive boys: comparative and c
Page 165 and 166: This version of HTA monograph volum
Page 167 and 168: 380 Health Technology Assessment Pr
Page 169: 382 Health Technology Assessment Pr
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