A systematic review and economic model of the effectiveness and ...
A systematic review and economic model of the effectiveness and ...
A systematic review and economic model of the effectiveness and ...
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24 TABLE 5<br />
Clinical <strong>effectiveness</strong><br />
MPH medium dose (15–30 mg/day) versus placebo<br />
Study Design Intervention – N Age Duration Core outcomes<br />
(years) (weeks)<br />
C (5×) MPH (20 mg/day, o.d.) – 45 5–12 5 Core: no hyp; ACTeRS: total score<br />
QoL: not reported<br />
AE: not reported<br />
Administered once daily<br />
Rapport, 1989 85<br />
C (5×) MPH (20 mg/day, o.d.) – 31 6–11 6 Core: no hyp; ACTeRS: total score<br />
QoL: not reported<br />
AE: not reported<br />
DuPaul, 1993 49<br />
Administered two or more times daily<br />
Conners, 1980 46<br />
P MPH (22.0 mg/day, b.d.) – 60 6–11 8 Core: Conners’ Parent Questionnaire: hyperactivity;<br />
Conners’ Teacher Questionnaire: hyperactivity<br />
QoL: no CGI; parent global judgements <strong>of</strong> improvement<br />
AE: Physician’s Rating Sheet for Side Effects St<strong>and</strong>ardised<br />
Form: 50-item checklist (parents); weight<br />
P MPH (20.08 mg/day, b.d.) – 40 5.7–13.1 3 months Core: CPRS: hyperactivity index; ACTeRs: hyperactivity<br />
QoL: not reported<br />
AE: not reported<br />
Brown, 1986 42<br />
C (4×) MPH (25.1 mg/day, b.d.) – 11 13–15 8 Core: CPRS-R: Hyperactivity Index; Conners’ Teacher<br />
Hyperactivity Index; ACTeRS: hyperactivity<br />
QoL: not reported<br />
AE: SERS (parents); weight<br />
Brown, 1988 43<br />
C (3×) MPH (0.60 mg/kg/day, b.d.) – 83 5–13 3 Core: not reported<br />
QoL: not reported<br />
AE: Stimulant Drug Side Effects Questionnaire: 17-item<br />
list<br />
Barkley, 1990 39<br />
C (3×) MPH (0.80 mg/kg/day, b.d.) – 161 2.4–17.2 3 Core: CPRS-R: Hyperactivity Index; CTRS-R: Hyperactivity<br />
Index; CTRS-R: hyperactivity<br />
QoL: not reported<br />
AE: CPRS-R: psychosomatic; SERS (parents, teachers):<br />
number <strong>and</strong> severity <strong>of</strong> side-effects<br />
Fischer, 1991 54<br />
C (3×) MPH (0.90 mg/kg/day, t.d.s.) – 234 5–15 4 Core: not reported<br />
QoL: not reported<br />
AE: BSEQ<br />
Ahmann, 1993 35<br />
continued