A systematic review and economic model of the effectiveness and ...

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Clinical effectiveness
TABLE 35 Results for hyperactivity (DEX-TR versus placebo)
Study Scale DEX-TR: mean (SD) Placebo: p-Value
mean (SD) (if reported) a
6–12 years
Arnold, 1989 38 CTRS (Hyperactivity Index) 1.39 (0.76) 2.10 (0.47) 20 mg/day) versus non-drug intervention
Study Design Intervention – N Age Duration Core outcomes
(years) (months)
Administered once daily
Conrad, 1971 47 P DEX (10–20 mg/day, o.d.?) vs 4–6 4–6 Core: no hyp; behaviour ratings
prescriptive tutoring – 17 (teacher, parent)
QoL: not reported
AE: not reported
P, parallel trial.
DEX medium dose (10–20 mg/day) plus non-drug
intervention versus placebo
One study evaluated medium-dose (10–20 mg/day)
DEX plus non-drug intervention compared with
placebo (Table 36; with additional information in
Appendix 12). In this study, DEX was
administered once daily, and the intervention
involved tutoring sessions twice per week. Conrad
and colleagues 47 did not evaluate hyperactivity or
CGI, but did report on behaviour ratings by
teachers and parents. The authors reported
improvements in the combined treatment group
compared with placebo (see Appendix 12).
Summary
No studies in this category measured hyperactivity,
CGI or adverse events as outcome measures.
DEX versus non-drug intervention
DEX high dose (>20 mg/day) versus non-drug
intervention
One study evaluated high-dose (>20 mg/day)
DEX compared with a non-drug intervention
(Table 37; with additional information in
Appendix 12). As presented above, this
intervention involved tutoring sessions twice per
week. Conrad and colleagues 47 did not evaluate
hyperactivity or CGI, but reported on behaviour
ratings by teachers and parents. The authors
reported greater improvements in the treatment
group than in the tutoring group, but the two
groups were not directly compared (see
Appendix 12).