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TABLE 1 The quality <strong>of</strong> included studies<br />

Study<br />

Was <strong>the</strong> method used to assign<br />

participants to <strong>the</strong> treatment<br />

groups really r<strong>and</strong>om?<br />

Was <strong>the</strong> sequence <strong>of</strong><br />

r<strong>and</strong>omisation concealed?<br />

Was blinding carried out?<br />

Who was blinded?<br />

© Queen’s Printer <strong>and</strong> Controller <strong>of</strong> HMSO 2006. All rights reserved.<br />

Health Technology Assessment 2006; Vol. 10: No. 23<br />

Ahmann, 1993 35 Poor Poor Yes P/#2 Unclear No No Yes Yes<br />

Arnold, 1976 36 Good Good Yes NR Unclear Unclear Unclear Yes Yes<br />

Arnold, 1978 37 Good Good Yes CL/#2 Unclear Unclear Unclear Yes Yes<br />

Arnold, 1989 38 Good Poor Yes NR Unclear Unclear Unclear Unclear Yes<br />

Barkley, 1990 39 Poor Poor Yes C/P/T/I Unclear Unclear Yes Yes? No<br />

Barkley, 2000 40 Poor Poor Yes C/P/T/I Unclear No Yes No No<br />

Brown, 1985 41 Poor Poor NR NA Unclear NA NA Yes No<br />

Brown, 1986 42 Poor Poor Yes P/T/I Unclear Unclear Partially Yes No<br />

Brown, 1988 43 Poor Poor Yes NR Unclear Unclear Unclear Yes No<br />

Buitelaar, 1996 44 Poor Poor Yes NR Unclear Yes NA Unclear No<br />

Conners, 1972 45 Poor Poor NR NA Unclear Unclear No Yes No<br />

Conners, 1980 46 Poor Poor Yes C/P/I Unclear Unclear Unclear Yes No<br />

Conrad, 1971 47 Poor Poor Yes P/T/CL/I Unclear Unclear No Yes No<br />

Dopfner, 2003 48 Poor Poor Yes NR Unclear No Yes Yes No<br />

DuPaul, 1993 49 Poor Poor Yes T/I Unclear No No Poor No<br />

Efron, 1997 50 Poor Poor Yes C/P/T/I Unclear Unclear Unclear Unclear No<br />

Elia, 1991 51 Poor Poor Yes NR Unclear Unclear Unclear No No<br />

Fine, 1993 52 Poor Poor Yes C/P/T/I Unclear NA NA No Yes<br />

Firestone, 1986 53 Poor Poor Yes P/T/CL Unclear Unclear Partially Yes? No<br />

Fischer, 1991 54 Poor Poor Yes C/P/T/I Unclear Unclear Yes Unclear No<br />

Fitzpatrick, 1992 55 Good Poor Yes #1 Unclear Unclear Unclear Partially No<br />

Gillberg, 1997 56 Poor Poor Yes C/P Unclear Yes Partially Yes No<br />

Gittelman-Klein, 1976 57 Poor Poor Yes NR Unclear Unclear Yes No Yes<br />

Greenberg, 1972 58 Poor Poor Yes NR Unclear Unclear Partially Yes? Yes<br />

Greenhill, 2002 59 Poor Poor Yes NR Unclear Yes/LOCF Partially Yes Yes<br />

H<strong>and</strong>en, 1999 60 Poor Poor Yes #6 Unclear Unclear Yes No No<br />

Hoeppner, 1997 61 Poor Poor Yes NR Unclear Unclear Unclear No No<br />

James, 2001 62 Poor Good Yes NR Unclear Unclear NA No Yes<br />

Kelsey, 2004 63 Poor Poor Yes NR Unclear Yes Yes Yes Yes<br />

Kemner, 2004 64 [Confidential information removed]<br />

Klein, 1997 65 Poor Poor Yes #4 Unclear Unclear Partially Yes No<br />

Klorman, 1987 66 Poor Poor Yes NR Unclear Unclear Unclear Poor No<br />

Klorman, 1990 67 Poor Poor Yes NR Unclear Unclear Unclear No No<br />

Klorman, 1994 68 Poor Poor Yes I/#2 Unclear Unclear Yes Unclear No<br />

Kolko, 1999 69 Poor Poor Yes #5 Unclear No Yes Unclear No<br />

Kratochvil, 2002 70 Poor Poor No NA Yes/LOCF Yes Yes Yes<br />

Kupietz, 1988 71 Poor Poor Yes P/T/I Unclear Unclear Partially Yes No<br />

Manos, 1999 72 Poor Poor Yes #3 Unclear Unclear NA No No<br />

Michelson, 2001 73 Good Good Yes NR Unclear Unclear Yes Yes Yes<br />

Michelson, 2002 74 Poor Poor Yes C/CL/I Unclear Yes/LOCF Partially Yes Yes<br />

Michelson, 2004 75 Poor Good Yes C/I Unclear Yes? Partially Yes Yes<br />

MTA, 1999 76 Poor Good Yes #7 Unclear Yes Partially Unclear No<br />

Pelham, 1987 77 Poor Poor Yes I/#2 Unclear Unclear Unclear Yes No<br />

Pelham, 1990 78 Poor Poor Yes NR Unclear Unclear Unclear Unclear No<br />

Pelham, 1993 79 Poor Poor Yes NR Unclear Unclear Unclear Unclear No<br />

Pelham, 1999 80 Poor Poor Yes P/T/I/CL Unclear Unclear Yes Unclear Yes<br />

Was blinding successful?<br />

Was an ITT analysis performed?<br />

Was a complete description <strong>of</strong> any<br />

withdrawals given?<br />

Was <strong>the</strong> statistical analysis<br />

appropriate?<br />

Was an association with industry<br />

reported by <strong>the</strong> authors?<br />

continued<br />

15

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