A systematic review and economic model of the effectiveness and ...
A systematic review and economic model of the effectiveness and ...
A systematic review and economic model of the effectiveness and ...
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20 TABLE 3<br />
Clinical <strong>effectiveness</strong><br />
MPH low dose (≤15 mg/day) versus placebo<br />
Study Design Intervention – N Age Duration Core outcomes<br />
(years) (weeks)<br />
C (5×) MPH (5 mg/day, o.d.) – 45 5–12 5 Core: no hyp; Abbreviated CTRS: total score<br />
MPH (10 mg/day, o.d.) – 45 QoL: not reported<br />
MPH (15 mg/day, o.d.) – 45 AE: not reported<br />
Administered once daily<br />
Rapport, 1989 85<br />
C (5×) MPH (5 mg/day, o.d.) – 31 6–11 6 Core: No hyp; Abbreviated CTRS: total score<br />
MPH (10 mg/day, o.d.) – 31 QoL: not reported<br />
MPH (15 mg/day, o.d.) – 31 AE: not reported<br />
DuPaul, 1993 49<br />
C (3×) MPH (0.40 mg/kg, o.d.) – 30 5.5–12.5 4 Core: Conners’ Teacher Questionnaire: hyperactivity;<br />
Conners’ Parent Questionnaire: hyperactivity<br />
QoL: CGI (physician)<br />
AE: weight<br />
Werry, 1980 96<br />
Administered two or more times daily<br />
Brown, 1988 43<br />
C (4×) MPH (8.76 mg/day, b.d.) –11 13–15 8 Core: CPRS: Hyperactivity Index; Conners’ Teacher<br />
Hyperactivity Index; ACTeRS: hyperactivity<br />
QoL: not reported<br />
AE: SERS (parents); weight<br />
C (3×) MPH (0.40 mg/kg/day, b.d.) – 161 2.4–17.2 3 Core: CPRS-R: Hyperactivity Index; CTRS-R: hyperactivity<br />
index; CTRS-R: hyperactivity<br />
QoL: not reported<br />
AE: CPRS-R: psychosomatic; SERS (parents, teachers):<br />
number <strong>of</strong> side-effects, mean severity rating<br />
Fischer, 1991 54<br />
C (4×) MPH (10–15 mg/day, b.d.) – 19 6.9–11.5 8 Core: Conners’ Hyperactivity Index (parents <strong>and</strong> teacher);<br />
TOTS: hyperactivity (parents <strong>and</strong> teachers)<br />
QoL: no CGI; comments ratings (parent/teacher)<br />
AE: STESS (parents); weight<br />
Fitzpatrick, 1992 55<br />
C (3×) MPH [0.30 mg/kg/day (unclear), b.d.] – 12 6–10 3 Core: not reported<br />
QoL: not reported<br />
AE: side-effects questionnaire<br />
Fine, 1993 52<br />
C (3×) MPH (0.30 mg/kg/day, b.d.) – 50 6.1–18.2 4 Core: CPRS: Hyperactivity Index; CTRS: Hyperactivity<br />
Index<br />
QoL: not reported<br />
AE: not reported<br />
Hoeppner, 1997 61<br />
continued