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TABLE 38 DEX medium dose (10–20 mg/day) plus non-drug intervention versus non-drug intervention
Summary
No studies in this category measured hyperactivity,
CGI or adverse events as outcome measures.
DEX medium dose (10–20 mg/day) plus non-drug
intervention versus non-drug intervention
Two studies evaluated medium-dose
(10–20 mg/day) DEX plus non-drug intervention
compared with a non-drug intervention (Table 38;
with additional information in Appendix 12).
The study by Conrad and colleagues 47 did not
report on hyperactivity, CGI or adverse events;
however, they did report on behavioural ratings
(see Appendix 12).
Hyperactivity
James and colleagues 62 evaluated hyperactivity
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Health Technology Assessment 2006; Vol. 10: No. 23
Study Design Intervention – N Age Duration Core outcomes
(years) (weeks)
Administered once daily
Conrad, 1971 47 P DEX (10–20 mg/day, o.d.?) vs 4–6 4–6 Core: no hyp; behaviour ratings
prescriptive tutoring – 17 (teacher, parent)
QoL: not reported
AE: not reported
Administered once weekly
James, 2001 62 C (4×) DEX (5–30 mg/kg once per 6.9–12.2 10 Core: CTRS: hyperactivity;
week for 2 weeks) vs formal Children’s Psychiatric Rating
academic instruction (a.m.) and Scale: hyperactivity (recreation
therapeutic recreation (p.m.) therapist rated); CPRS:
(full time, 10 weeks) – 35 hyperactivity
QoL: not reported
AE: Stimulant Side Effect Rating
Scale (nurse); Barkley Side Effect
Rating Scale (parent); weight
C, Crossover trial (number of crossovers); CPRS, Conners’ Parent Rating Scale; CTRS, Conners’ Teacher Rating Scale;
P, parallel trial.
TABLE 39 Results for hyperactivity [DEX medium dose (10–20 mg/day) plus non-drug intervention versus non-drug intervention]
Study Scale DEX medium dose + Non-drug: p-Value
non-drug: mean (SD) mean (SD) (if reported) a
6–12 years
James, 2001 62 CTRS (hyperactivity) 50.5 (5.4) 63.1 (12.6) S – NR
Children’s Psychiatric Rating Scale 2.5 (1.1) 3.8 (1.1)