A systematic review and economic model of the effectiveness and ...

TABLE 22 MPH low dose (≤ 15 mg/day) plus non-drug intervention versus non-drug intervention
Study Design Intervention – N Age Duration Core outcomes
(years) (weeks)
Administered once daily
Kupietz, 1988 71 P MPH (0.3 mg/kg, o.d.) vs one-to-one 7–13 6 months Core: CTRS: hyperactivity
reading therapy (6 months) – 58 QoL: not reported
AE: not reported
MPH (0.5 mg/kg, o.d.) vs one-to-one
reading therapy (6 months) – 58
Pelham, 1999 81 C (7×) MPH (0.3 mg/kg/day, o.d.) vs behavioural 6–12 6 Core: no hyp; IOWA-C: inattention/overactivity (teachers
programme – 21 and parents)
QoL: not reported
AE: Pittsburgh Side Effect Rating Scale (counsellors, teachers,
parents)
Administered two or more times daily
Brown, 1985 41 P MPH (5–15 mg/day, b.d.) vs cognitive training 6.3–11.8 6 months Core: no hyp; CPRS; ACTRS
(12 weeks, 24 sessions) – 30 QoL: not reported
AE: not reported
© Queen’s Printer and Controller of HMSO 2006. All rights reserved.
ACTRS, Abbreviated Conners’ Teacher Rating Scale; C, crossover trial (number of crossovers); CPRS, Conners’ Parent Rating Scale; CTRS, Conners’ Teacher Rating Scale; P, parallel
trial.
Health Technology Assessment 2006; Vol. 10: No. 23
TABLE 23 Results for hyperactivity MPH low dose (≤ 15 mg/day) plus non-drug intervention versus non-drug intervention
Study Scale MPH low dose + non-drug: mean (SD) Non-drug: mean (SD) Mean difference
7–13 years
Kupietz, 1988 71 CTRS (hyperactivity) 0.3 mg/kg: MD (95% CI)
2.21 (0.53) 2.89 (0.69) –0.47 (–0.84 to –0.10)
0.5 mg/kg:
2.04 (0.43) –0.76 (–1.06 to –0.46)
Lower scores represent a better behavioural outcome.
CTRS, Conners’ Teacher Rating Scale.
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