A systematic review and economic model of the effectiveness and ...

More documents

Recommendations

Info

HTA How to obtain copies of this and other HTA Programme reports. An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk). A fully searchable CD-ROM is also available (see below). Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents. Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph. You can order HTA monographs from our Despatch Agents: – fax (with credit card or official purchase order) – post (with credit card or official purchase order or cheque) – phone during office hours (credit card only). Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: HTA Despatch Email: orders@hta.ac.uk c/o Direct Mail Works Ltd Tel: 02392 492 000 4 Oakwood Business Centre Fax: 02392 478 555 Downley, HAVANT PO9 2NP, UK Fax from outside the UK: +44 2392 478 555 NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30–40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Payment methods Paying by cheque If you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit card The following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD? Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide. The website also provides information about the HTA Programme and lists the membership of the various committees.
A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents S King, 1* S Griffin, 2 Z Hodges, 1 H Weatherly, 2 C Asseburg, 2 G Richardson, 2 S Golder, 1 E Taylor, 3 M Drummond 2 and R Riemsma 1 1 Centre for Reviews and Dissemination, University of York, UK 2 Centre for Health Economics, University of York, UK 3 Institute of Psychiatry, King’s College London, UK * Corresponding author Declared competing interests of authors: E Taylor acted as a representative of the RCP at the NICE Appraisal Committee meeting. R Riemsma is a member of the editorial board for Health Technology Assessment, but he was not involved in the editorial process for this report. Published July 2006 This report should be referenced as follows: King S, Griffin S, Hodges Z, Weatherly H, Asseburg C, Richardson G, et al. A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. Health Technol Assess 2006;10(23). Health Technology Assessment is indexed and abstracted in Index Medicus/MEDLINE, Excerpta Medica/EMBASE and Science Citation Index Expanded (SciSearch ® ) and Current Contents ® /Clinical Medicine.
Page 1: A systematic review and economic mo
Page 5 and 6: Objectives: To assess the clinical
Page 7 and 8: Glossary and list of abbreviations
Page 9 and 10: Glossary Adverse effect An abnormal
Page 11 and 12: Glossary continued effects. Sometim
Page 13 and 14: Glossary continued point between tw
Page 15 and 16: Background Attention deficit hypera
Page 17 and 18: mean differences with 95% confidenc
Page 19: This review examines the clinical a
Page 22 and 23: 4 Background E. Symptoms should not
Page 24 and 25: 6 Background Concerta XL Concerta X
Page 26 and 27: 8 Methods for reviewing effectivene
Page 28 and 29: 10 Methods for reviewing effectiven
Page 31 and 32: Quantity and quality of research av
Page 33 and 34: TABLE 1 The quality of included stu
Page 35 and 36: TABLE 2 An overview of trials inclu
Page 37 and 38: TABLE 2 An overview of trials inclu
Page 39 and 40: TABLE 3 MPH low dose (≤15 mg/day)
Page 41 and 42: Quality of life Only one of the 12
Page 43 and 44: TABLE 5 MPH medium dose (15-30 mg/d
Page 45 and 46: Hyperactivity All nine studies that
Page 47 and 48: TABLE 6 Results for hyperactivity [
Page 49 and 50: Study Parallel trials Buitelaar 199
Page 51 and 52: TABLE 8 Results for hyperactivity [
Page 53 and 54:
Study Parallel trials Gittelman-Kle
Page 55 and 56:
TABLE 11 MPH high dose (>30 mg/day)
Page 57 and 58:
TABLE 14 ER-MPH medium dose (20-40
Page 59 and 60:
Study Crossover trials Stein 2003 S
Page 61 and 62:
TABLE 19 Results for hyperactivity
Page 63 and 64:
TABLE 22 MPH low dose (≤ 15 mg/da
Page 65 and 66:
TABLE 24 MPH medium dose (15-30 mg/
Page 67 and 68:
assessed by parents and teachers. I
Page 69 and 70:
Page 71 and 72:
TABLE 30 DEX medium dose (10-20 mg/
Page 73 and 74:
Page 75 and 76:
TABLE 38 DEX medium dose (10-20 mg/
Page 77 and 78:
TABLE 41 DEX-SR plus non-drug inter
Page 79 and 80:
Study Michelson 2001 [0.5] Michelso
Page 81 and 82:
Hyperactivity Five trials (publishe
Page 83 and 84:
TABLE 47 IR-MPH low-dose (≤ 15 mg
Page 85 and 86:
STP. 77,78 Neither examined hyperac
Page 87 and 88:
Adverse events No significant diffe
Page 89 and 90:
did report that there were no signi
Page 91 and 92:
Summary The one study in this categ
Page 93 and 94:
showed persisting significant super
Page 95 and 96:
easily rectified with dosage adjust
Page 97 and 98:
Aim The aim of this chapter is to r
Page 99 and 100:
only level of social disability tha
Page 101 and 102:
did not include a ‘global’ HRQo
Page 103 and 104:
might decrease but costs would be e
Page 105 and 106:
1st line pharmacotherapy Response,
Page 107 and 108:
TABLE 70 Data for weighted average
Page 109 and 110:
The probabilistic results were used
Page 111 and 112:
The review also uncovered a mis-ref
Page 113 and 114:
TABLE 77 Results of sensitivity ana
Page 115 and 116:
TABLE 80 Response a rates (%) estim
Page 117 and 118:
TABLE 82 Drug costs used in the cos
Page 119 and 120:
The review of the economic evidence
Page 121 and 122:
Extrapolation A secondary analysis
Page 123 and 124:
economic model rests on the assumpt
Page 125 and 126:
TABLE 87 Data used in calculating w
Page 127 and 128:
not fully probabilistic. The averag
Page 129 and 130:
Probability cost-effective 1.0 0.9
Page 131 and 132:
TABLE 93 Results of sensitivity ana
Page 133 and 134:
Base case model Responder to MPH Re
Page 135 and 136:
TABLE 96 Results of the sensitivity
Page 137 and 138:
The same method for synthesising th
Page 139 and 140:
TABLE 103 Results of the economic m
Page 141:
of the 64 identified in the clinica
Page 144 and 145:
126 Discussion impact of active dru
Page 147:
MPH, DEX and ATX improve hyperactiv
Page 151 and 152:
1. National Institute for Clinical
Page 153 and 154:
tutoring on the behavior and achiev
Page 155 and 156:
91. Stein MA, Blondis TA, Schnitzle
Page 157 and 158:
140. Hill P, Taylor E. An auditable
Page 159 and 160:
189. Francis S, Fine J, Tannock R.
Page 161 and 162:
235. Rhodes SM, Coghill DR, Matthew
Page 163 and 164:
hyperactive boys: comparative and c
Page 165 and 166:
This version of HTA monograph volum
Page 167 and 168:
380 Health Technology Assessment Pr
Page 169:
382 Health Technology Assessment Pr
show all

A systematic review and economic model of the effectiveness and ...

Create successful ePaper yourself

Delete template?

Save as template?