Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

398
Rat, LC 50
, inhalation
Rabbit, skin irritation
Rabbit, eye irritation
Guinea-pig, skin sensitization (test
method used and result)
Short-term studies of toxicity
Target/critical effect
> 3.4 mg/l of air (maximum achievable concentration)
Not irritating
Slight irritant
Positive in maximization test, negative in Buehler test
Food consumption/body-weight gain; liver (rats, mice, dogs); haematological
effects (dogs)
20 mg/kg bw per day (1-year study in dogs)
714 mg/kg bw per day (28-day, 20 exposures, rats)
Negative in a battery of tests in vitro and in vivo. No genotoxic potential.
Lowest relevant oral NOAEL
Lowest relevant dermal NOAEL
Genotoxicity
Long-term studies of toxicity and carcinogenicity
Target/critical effect (rats) Kidney & liver weight (both sexes) and glomerulonephrosis (males); body weight.
Lowest relevant NOAEL/NOEL 20 mg/kg bw per day (2-year study in rats)
Carcinogenicity
No evidence of treatment related tumorigenicity in rats or mice
Reproductive toxicity
Reproduction target/critical effect No effects on reproductive indices
Reduction in body-weight gain in offspring during lactation
Lowest relevant reproductive 20 mg/kg bw per day (parents and offspring)
NOAEL
110 mg/kg bw per day (r eproduction)
Developmental target/critical effect
Lowest relevant developmental
NOAEL
Neurotoxicity / delayed neurotoxicity
Acute neurotoxicity
12-month i nvestigation of neurotoxicity
within a long-term study
in rats
Other toxicological studies
Induction of liver xenobiotic
m etabolizing enzymes (2-week
dietary study)
Medical data
No specific fetal effects
80 mg/kg bw per day (maternal toxicity in rabbits).
80 mg/kg bw per day (fetal effects)
No adverse effects
No neurotoxic effects.
NOAELs: 45 mg/kg bw per day (rats); 55 mg/kg bw per day (mice)
Sensitization in production-plant personnel. No other adverse effects r eported.
Summary
Value Study Safety factor
ADI 0–0.2 mg/kg bw Rat, 2-year study;
100
dog, 1-year study;
rat, study of reproductive toxicity
ARfD Unnecessary — —
QUINOXYFEN X-X JMPR 2006