Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

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Table 14. Summary of identified metabolites in urine and faeces of rats
given [pyridine 3- 14 C]boscalid at a dose of 500 mg/kg bw a
Metabolite
Total excretion (% of administered dose)
Urine
(0–48 h)
Faeces
(0–48 h)
Male Female Male Female
M510F47 0.10 0.07 — —
M510F02 0.08 1.64 — —
M510F42 0.48 0.05 — —
M510F48 0.04 0.26 — —
M510F04 0.01 0.01 — —
M510F05 0.17 0.03 — —
M510F01 2.93 0.94 4.84 4.35
M510F12 0.34 0.04 — —
M510F20 0.26 0.06 — —
Boscalid 0.07 0.02 72.91 70.16
M510F06 — — 7.59 3.81
M510F63 — — 0.46 0.25
From Grosshans & Knoell (2001)
a
Dose groups from the kinetic study (see Table 1)
Table 15. Summary of metabolites identified in
bile of female rats given [diphenyl U- 14 C]boscalid
as a single oral dose at 50 mg/kg bw or 500 mg/kg bw
Metabolite
Total excretion
(% of administered dose)
Dose (mg/kg bw)
50 500
M510F02 19.27 4.78
M510F57 1.32 0.41
M510F58 0.27 0.09
M510F03 1.48 0.21
M510F22/F23 — 0.10
M510F05 14.24 3.59
M510F01 1.71 0.28
From Grosshans & Knoell (2001)
All metabolites were present in the liver at less than 0.3% of the administered dose. The
m etabolites M510F01, M510F02, M510F05, and M510F06 already identified in urine and faeces
were also found in the liver. In addition, the metabolite M510F46 (introduction of a hydroxyl group
and a glutathione group in the diphenyl ring moiety), the metabolite M510F45 (introduction of a
glutathione group in the diphenyl ring moiety), and the metabolite M510F43 (exchange of chlorine
for glutathione in the pyridine moiety) were identified (Table 16).
BOSCALID X-X JMPR 2006