Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

BOSCALID
First draft prepared by
D.B. McGregor 1 and Roland Solecki 2
1
Toxicity Evaluation Consultants, Aberdour, Scotland; and
2
Federal Institute for Risk Assessment, Berlin, Germany
Explanation ....................................................................................................... 47
Evaluation for acceptable daily intake .............................................................. 48
1. Biochemical aspects ............................................................................ 48
1.1 Absorption, distribution and excretion ........................................ 48
2. Toxicological studies ........................................................................... 70
2.1 Acute toxicity .............................................................................. 70
2.2 Short-term studies of toxicity ...................................................... 72
2.3 Long-term studies of toxicity and carcinogenicity ...................... 78
2.4 Genotoxicity ................................................................................ 83
2.5 Reproductive toxicity ................................................................... 85
(a) Multigeneration studies ........................................................ 85
(b) Developmental toxicity ........................................................ 87
2.6 Special studies ............................................................................. 90
(a) Neurotoxicity ........................................................................ 90
(b) Liver and thyroid effects ...................................................... 92
(c) Immunotoxicity .................................................................... 93
3. Observations in humans ...................................................................... 94
Comments ..........................................................................................................94
Toxicological evaluation ................................................................................... 96
References ......................................................................................................... 98
Explanation
Boscalid is the provisionally approved International Organization of Standardization (ISO)
name for 2-chloro-N-(4’-chlorobiphenyl-2-yl)nicotinamide (International Union of Pure and Applied
C hemistry, IUPAC) or 2-chloro-N-(4’-chloro[1,1’-biphenyl]-2-yl)-3-pyridinecarboxamide (C hemical
Abstracts Service, CAS). It is an anilide fungicide that inhibits mitochondrial respiration, thereby
inhibiting spore germination, germ-tube elongation, mycelial growth, and sporulation of pathogenic
fungi on the leaf surface, and is used against a broad spectrum of diseases in a wide range of crops.
Boscalid was reviewed for the first time by the present Meeting at the request of the Codex Committee
on Pesticide residues (CCPR). All critical studies complied with good laboratory practice (GLP).
BOSCALID X-X JMPR 2006