Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

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Table 12. Summary of metabolites identified in urine and faeces of rats
given boscalid as 15 daily oral doses at 500 mg/kg bw (14 doses nonradiolabelled,
last dose with radiolabelled [diphenyl U- 14 C]boscalid)
Metabolite
Total excretion (% of administered dose)
Urine
(0–48 h)
Faeces
(0–48 h)
Male Female Male Female
M510F02 0.22 1.03 — —
M510F03 — 0.07 — —
M510F42 0.26 — — —
M510F48 0.02 0.26 — —
M510F04 — 0.02 — —
M510F05 0.04 0.08 — —
M510F01 1.34 1.94 2.46 12.60
M510F11 — — 0.14 —
M510F12 0.06 — — —
M510F20 0.14 0.04 — 0.51
Boscalid 0.11 0.05 85.15 75.82
M510F06 — — 2.60 1.41
M510F63 — — 0.14 —
From Grosshans & Knoell (2001)
Table 13. Summary of identified metabolites in urine and faeces of rats
given [diphenyl U- 14 C]boscalid at a dose of 500 mg/kg bw a
Metabolite
Total excretion (% of administered dose)
Urine
(0–48 h)
Faeces
(0–48 h)
Male Female Male Female
M510F02 0.69 2.41 — —
M510F42 0.22 0.08 — 0.20
M510F03 — — — —
M510F48 0.03 0.47 0.42 0.63
M510F04 — 0.04 — —
M510F05 0.09 0.07 — —
M510F01 1.04 1.52 4.10 5.50
M510F11 — — 1.33 0.58
M510F20 0.05 0.10 — —
Boscalid 0.16 0.04 80.37 68.26
M510F06 — — 7.00 3.00
M510F63 — — 0.32 1.35
From Grosshans & Knoell (2001)
a
Dose groups from the kinetic study (see Table 1)
BOSCALID X-X JMPR 2006