Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

442
Dose (mg/kg bw)
(grouped by
experiment)
No. of litters with malformed fetuses/No. examined a Percentage with malformation b of m alformed
fetuses/No.
e xamined
Reduction Short or
d eformity of limbs c absent tail
No. of fetuses with:
Anal
atresia
Cleft
palate
Open
eyelids
Exencephalia Omphalocele
60 3/27 (11.1) 1.8 ± 6.1 5/361 0 0 0 3 2 1 0
30 4/28 (14.3) 1.2 ± 3.1 5/387 0 0 0 0 5 0 0
0 2/27 (7.4) 0.5 ± 1.9 2/347 0 0 0 0 2 0 0
From Ogata et al. (1984)
a
Shown as a percentage in parentheses.
b
Calculated by averaging the percentage in each litter (i.e. No. of malformations/No. of fetuses) and shown as mean ± standard deviation.
c
In parentheses: No. of litters with affected fetuses; percentage of affected litters among those examined.
d
The chi-squared test was used to compare the number of affected litters.
Values marked with asterisks are significantly different from those in the corresponding control group (*p < 0.05, **p < 0.01, ***p < 0.001) as determined by the following statistical tests:
chi-squared test (total incidence of litters with malformed fetuses and incidences of litters having fetuses with specific malformations); rank sum test (% incidence of malformations).
THIABENDAZOLE X-X JMPR 2006