Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

425
Lowest relevant developmental NOAEL
Neurotoxicity studies in hens
Lowest relevant neurotoxicity NOAELs
10 mg/kg bw per day for maternal toxicity
30 mg/kg bw per day (highest dose tested) for developmental
effects
1705 mg/kg bw (highest dose tested caused no neuropathy)
Observations in humans
Volunteer studies
No effects on plasma or erythrocyte cholinesterase activity at
1.1 mg/kg bw per day for 4 weeks, or at 4.27 mg/kg bw per
day for 5 days
References
Allen, J.S. (1986) Bacterial microsome reverse mutation (Ames) test on AC 52,160 (Lot AC 5105-43).
Unpublished report No. GTOX Vol 6, No 1 (BASF Registration Document No TM-435-003) from American
Cyanomid Company, Princetown, New Jersey, USA. Submitted to WHO by BASF.
Barfknecht, T.R. (1986) Rat hepatocyte primary culture/DNA repair test – AC 52,160 (Lot AC 5105-43).
Unpublished report No. PH 311-AC-004-85 (BASF Registration Document No. TM-435-004) from
Pharmakon Research International Inc., Waverly, Pennsylvania, USA. Submitted to WHO by BASF.
Beliles, R.P. & Makris, S.L. (1978) Teratology study in rabbits – Abate technical. Unpublished report No. 20740-B
(BASF Registration Document No. TM-432-003) from Litton Bionetics, Inc., Kensington, Maryland, USA.
Submitted to WHO by BASF.
Blinn, R.C. (1966) Abate insecticide: The metabolic fate of 0,0,0’,0’-tetramethyl 0,0’-thio-p-phenylene
phosphothioate in the rat. Unpublished final report for project No. 35-54-3-11-83 (BASF Registration
Document No. TM-440-001) from American Cyanomid Company, Princetown, New Jersey, USA.
Submitted to WHO by BASF.
Brusick, D. (1976) Mutagenicity evaluation of ps-665 0,0,0’,0’-tetramethyl-0,0’-thio-di-p-phenylene phosphoro
thioate 90%. Unpublished report (BASF Registration Document No. TM-435-001) from Litton Bionetics
Inc., Kensington, Maryland, USA. Submitted to WHO by BASF.
Costello, B. (1986) AC52160 Lot# AC5105-43: dermal sensitization study in guinea pigs. Unpublished report
for project No. 85-4807A (BASF Registration Document No. TM-416-002) from Bioresearch Inc.,
Philadelphia, PA, USA. Submitted to WHO by BASF.
Fischer, J.E. (1986) Toxicity data report: 0,0,0’,0’-tetramethyl-0,0’-thiodi-p-phenylene phosphothioate.
Unpublished report No. A86-7 (BASF Registration Document No. TM-410-002) from American Cyanomid
Company, Princetown, New Jersey, USA. Submitted to WHO by BASF.
Fletcher, D.W. & Leonard, M.I. (1986) 42-day Neurotoxicity study with temephos technical in mature white
leghorn chickens. Unpublished report No. 85 DN 107 (BASF Registration Document No TM-451-002)
from Bio-Life Associates Ltd, Neillsville, Wisconsin, USA. Submitted to WHO by BASF.
Gaines, T.B, Kimborough, R. & Laws, E.R. Jr. (1967) Toxicology of Abate in laboratory animals. Archives of
Environmental Health, 14, 283–288.
Hutchinson, E.B. & Levinskas, G.J. (1965) CL 52,160: ninety-day repeated feeding to dogs. Unpublished Environmental
Health Laboratory report No. 65-19 (BASF Registration Document No. TM-425-002.from American Cyanomid
Company, Central Medical Department, Wayne, New Jersey, USA. Submitted to WHO by BASF.
Hutchinson, E.B., McNerney, J.M. & Levinskas, G.J. (1966) Abate mosquito lavicide: ninety-day repeated
feeding to rats (CL 52,160). Unpublished Environmental Health Laboratory report No. 66-162 (BASF
Registration Document No. TM-425-003) from American Cyanomid Company, Central Medical
Department, Wayne, New Jersey, USA. Submitted to WHO by BASF.
TEMEPHOS X-X JMPR 2006