Pesticide residues in food — 2006: Toxicological ... - ipcs inchem

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Table 6. Excretion of radioactivity and radioactive residues of 14 C-thiazolidine-labelled
thiacloprid in rats
Sample Time-point Excretion of radioactivity and radioactive residues
(% of administered dose)
1 mg/kg bw 100 mg/kg
Males Males Females Males
Urine 4 h 3.87 6.64 9.62 4.64
8 h 26.09 36.57 27.31 10.98
24 h 66.31 71.31 77.01 32.18
48 h 72.71 76.82 82.90 60.23
Faeces 24 h 15.73 11.95 8.47 0.98
48 h 18.60 14.46 10.47 13.28
Expired air 48 h 0.86 — — —
Total excreted 91.51 91.28 93.37 73.51
Carcass 6.85 2.77 1.36 8.12
Gastrointestinal tract 0.45 0.40 0.21 4.25
Total recovery 99.68 94.45 94.94 85.88
From Printz & Bornatsch (1997)
Total tissue residues at 48 h in the group at the lowest dose accounted for 1.6–3.3% of the
radioactivity administered (Table 7). Residues were highest in the liver in all groups at the lowest
dose. In the group at the highest dose, residues accounted for 12.4% of the administered radioactivity,
largely due to high residues in the gastrointestinal tract. Findings indicated delayed absorption or
faecal excretion in this group.
Table 7. Residual radioactivity in organs and tissues of rats 48 h after dosing with 14 C-thiazolidine
labelled thiacloprid
Organ/tissue
Residual radioactivity (μg/g equivalent)
1 mg/kg 100 mg/kg
Males Females Males
Erythrocytes 0.021 0.015 7.612
Plasma 0.023 0.018 10.086
Spleen 0.032 0.021 10.329
Gastrointestinal tract 0.028 0.019 34.674
Liver 0.109 0.072 36.080
Kidney 0.063 0.046 19.484
Fat 0.001 0.005 6.306
Adrenals 0.061 0.040 29.561
Gonads 0.015 — 6.698
Uterus — 0.019 —
Muscle 0.013 0.006 5.533
Bone 0.024 0.012 6.602
Heart 0.018 0.012 8.020
Lung 0.029 0.023 10.996
Brain 0.008 0.005 5.000
THIACLOPRID X-X JMPR 2006