Here - American Geriatrics Society

P OSTER
A BSTRACTS
Methods: The Honolulu-Asia Aging Study (HAAS) is a longitudinal
cohort study of aging, cognition and movement disorders in
Japanese-American men in Hawaii, which began in 1991 among survivors
of the Honolulu Heart Program cohort, followed since 1965.
The fifth examination cycle was held in 1994-96, when 2,705 men ages
74 to 95 years were examined. Subjects were administered simple RT
(SRT) and choice RT (CRT) tests performed with a laptop computer.
Subjects were divided into quartiles based on reaction time. Diagnosis
of PD was based on consensus from at least 2 neurologists according
to published criteria. Incident PD data were available for 7 years
of follow-up, and those with prevalent PD were excluded. Separate
analyses were performed for SRT and CRT, using the lowest quartile
of each as reference.
Results: There were 25 cases of incident PD during follow-up,
and incidence rates increased by quartiles of SRT, from 5.7, to 20.0, to
19.1, to 25.0 per 10,000 person-years follow up, p for trend=0.03.
Using multivariate Cox regression, adjusting for age, education, baseline
cognitive test score, prevalent stroke, handedness, handgrip
strength, percent SRT error rate and amount of caffeine intake, men
in the highest (slowest) quartile of SRT were significantly more likely
to develop incident PD (RR=5.32, 95% CI=1.05-26.9, p=0.04). Analyses
were repeated on men who were cognitively intact at baseline and
without prevalent stroke, and those in the highest quartile of SRT still
had higher incidence of PD (RR=5.03, 95% CI=0.96-26.2, p=0.055).
We found no significant associations between CRT and incident PD.
Conclusions: Men in the slowest quartile of SRT were significantly
more likely to develop incident PD compared to those in the fastest
quartile. Measurement of RT is a low-cost method that may help to
identify those at risk for PD who may benefit from early intervention.
B125
Neuropsychological and Functional Performance in Adult
Protective Services Clients.
M. T. Le, D. J. Goldstein, J. E. Schillerstrom. University of Texas
Health Science Center at San Antonio, San Antonio, TX.
Supported By: The research reported on this abstract was supported
by Hartford/AFAR Medical Student Training in Aging Research
(MSTAR) Program.
Background: In fiscal year of 2010, Texas Adult Protective
Services (APS) validated 56,053 cases of neglect, abuse, or exploitation.
The UTHSCSA Department of Psychiatry performs decisionalcapacity
assessments across Region 8 which encompasses 29 Texas
counties. In Texas, the legal definition of decisional capacity is heavily
dependent on the functional status of the client. The purpose of this
study was to determine which cognitive domains contribute independent
variance to instrumental activities of daily living (IADL) in
elderly APS referrals. Methods: We performed a retrospective
medical record review of referrals (n=157 of which n=75 subjects
completed all measures), calculated Spearman correlation coefficients
between cognitive and functional scores, and regressed neuropsychological
measures onto IADL to search for independent contributions.
Results: There was no correlation between IADL and
the Geriatric Depression Scale. IADL correlated significantly with
the Executive Interview (r=0.68, p